Kanamycin (Topical) in Pyodermas

Blau, S; Kanof, Norman B.; Rogin, James R.

doi:10.1111/j.1749-6632.1958.tb54711.x

Cited by 2 publications

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“…Surgicel, a knitted fabric prepared by the controlled oxidation of regenerated cellulose, is a light/pale yellow color sterile gauze-type absorbable hemostatic. It is clinically effective as an adjuvant for capillary and venous hemorrhage in various fields of operation, and is absorbed without leaving any foreign body after being used for wound hemostasis in peeling, tissue biopsy, nail avulsion, and trauma [ 9 , 10 ]. Moreover, there is a report of the antibiotic effect after the use of Surgicel in vivo, and growth of antibiotic resistant strains were also found to be effectively suppressed [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study

Kang

Jin

2012

Arch Plast Surg

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BackgroundMany topical hemostatics are widely applied for bleeding control. They can be classified into two categories according to their mechanism of action on the clotting cascade in a biologically active or passive manner. Passive hemostatics include cellulose and gelatin. We performed an experimental study to compare the effect of passive hemostatics in wound healing by applying them to a rectus abdominis muscle defect of white mice.MethodsSurgicel is a sterile absorbable knitted fabric prepared by the controlled oxidation of regenerated cellulose. Spongostan is an absorbable hemostatic gelatin sponge. In 30 mice, a 1×1 cm defect was created on the rectus abdominis muscle and the materials were applied in three ways: control group, cellulose (Surgicel) group, gelatin (Spongostan) group. For the histologic analysis, biopsies were performed at 3 and 28 days.ResultsAfter 3 days, the cellulose group showed limited granulation formation with acute inflammatory reactions similar to the control group. At the 28th day, moderate amounts of granulation tissue formation was observed with milder inflammatory reactions than the control group. In the gelatin group, after 3 days, gelatin remnants were observed surrounded by severe inflammatory changes. After 28 days, the same quantity of gelatin remnants could be still observed.ConclusionsThis study suggests that cellulose is associated with minimal morbidity in wound healing, while the use of gelatin shows severe adverse tissue reactions with delayed wound healing. Consequently, cellulose is better than gelatin when considering wound healing.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study

Kang

Jin

2012

Arch Plast Surg

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Contact dermatitis to antituberculosis drugs

Holdiness¹

1986

Contact Dermatitis

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The literature has been reviewed for contact dermatitis occurring to antituberculosis agents. Of the 12 known drugs, 6 (isoniazid, rifampicin, ethambutol, para-aminosalicylic acid, streptomycin and kanamycin) have been documented by patch test to cause this type of dermatitis in certain individuals. Cross sensitization has been observed to contribute significantly to the allergic reactions noted from isoniazid, streptomycin, and kanamycin. Hyposensitization has also been discussed in this review.

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Kanamycin (Topical) in Pyodermas

Cited by 2 publications

References 0 publications

Comparison of the Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study

Comparison of the Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study

Contact dermatitis to antituberculosis drugs

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