Contact dermatitis to antituberculosis drugs

Holdiness, Mack R.

doi:10.1111/j.1600-0536.1986.tb01369.x

Cited by 15 publications

(4 citation statements)

References 23 publications

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“…The incidence of adverse reactions to isoniazid treatment is low, the most common being hepatic and neurological (1–3). Skin reactions (4–6) and fever, as isolated symptoms, have also been described (7, 8).…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity syndrome from isoniazid with positive patch test

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Hypersensitivity syndrome from isoniazid with positive patch test

et al. 2001

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“…However, the patient's skin lesions were not eczematous (characterized by erythema, vesiculation, exudation, or bullous edema in the acute phase), and were not localized to areas of irritant exposure. 3 In our patient, erythematoedematous lesions in an acral distribution with no mucosal involvement and systemic exposure to INH was compatible with erythema multiforme, whereas the absence of target appearance, positive patch test, and late appearance were incompatible with erythema multiforme. 8 Because the clinical picture did not fit contact dermatitis or erythema multiforme, a diagnosis of erythema multiforme-like noneczematous dermatitis was suggested.…”

Section: Practice Pointsmentioning

confidence: 44%

“…The challenge in TB treatment is adverse drug reactions (ADRs) that are reported in 4% to 6% of cases. 2,3 Erythema multiforme-like dermatitis is a rare skin rash that develops due to isoniazid (INH). The clinical presentation includes erythematoedematous lesions in an acral distribution with no mucosal involvement and systemic exposure to INH.…”

mentioning

confidence: 99%

Erythema Multiforme–like Dermatitis Due to Isoniazid Hypersensitivity in a Patient With Psoriasis

Baççıoğlu

Karabulut

Kalpaklıoğlu

2021

Cutis

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“…Cutaneous eruptions from isoniazid have been described in less than 1% of the patients treated. Cases of contact dermatitis have also been described in nurses and workers in the pharmaceutic industry ( 4, 5).…”

mentioning

confidence: 99%

Hypersensitivity syndrome from isoniazid

Rubira

Baltasar

Martí

1999

Allergy

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immunity since colonization of the upperrespiratory tract (e.g., with Neisseria meningitidis, Haemophilus in¯uenzae, or Streptococcus spp.) occurs early in life, resulting in 1/4 individuals being temporarily affected. It is known that irritating stimuli, such as LPS, can convert a tolerizing immune response into an allergic IgE-based response (4). Intriguingly, we recently found that neisserial IgA1 protease that is secreted in conjunction with the cross-reacting a-proteins is a potent inducer of proin¯ammatory cytokines (Lorenzen et al., submitted). Therefore, colonization with N. meningitidis and related pathogens might trigger allergic responses against otherwise harmless proteins. Furthermore, structural similarity with host proteins (Fig. 1) may stimulate the allergic memory over the winter season. The nasopharyngeal carriage of microbial pathogens in children with a history of atopic diseases (5) and the increased development of allergic symptoms in meningococcal stockvaccinated patients (6) support the signi®cance of our observations. However, the clinical relevance of our ®ndings remains to be established. References 1. Smith PM, Ong EK, Knox RB, Singh MB. Immunological relationship among group I and V allergens from grass pollen. Mol Immunol 1994;31:491±498. 2. Schenk S, Breiteneder H, Susani M, et al. T-cell epitopes of Phl p I, major pollen allergen of timothy grass (Phleum pratense): evidence for cross-reacting and non-cross-reacting T-cell epitopes within grass group I allergens. J Allergy Clin Immunol 1995;96: 986±996. 3. Mohapatra SS, Mohapatra S, Yang M, et al. Molecular basis of cross-reactivity among allergen-speci®c human T-cells: T-cell receptor V usage and epitope structure. Immunology 1994;81:15±20. 4. Holt PG, Britten D, Sedgwick JD. Suppression of IgE-responses by antigen inhalation: studies on the role of genetic and environmental factors. Immunology 1986;60:97±102. 5. Sorensen CH, Kilian M. Bacterium-induced cleavage of IgA in nasopharyngeal secretions from atopic children. APMIS 1984;92:85±87. 6. Borysova L, Tomsikova M, Kuzenska P, Burian V. Allergisation of the organism by Neisseria meningitidis. II. Studies concerning the results of vaccine therapy in diseases carried by bacterial allergy. Z Bakt Hyg . We present a 34-year-old woman with a personal background of smoking and simple chronic bronchitis with bronchial hyperreactivity. Diagnosed with pulmonary tuberculosis, she began triple tuberculostatic treatment with isoniazid, rifampicin, and pyrazinamide. After 2 months, she visited the hospital with a severely pruritic urticariform cutaneous eruption; treatment was started with chlorpheniramine, and pyrazinamide was discontinued because the treatment had been completed. One week later, she was admitted to the emergency department because of a worsening of the eruption, with edema in the face and neck, purpuric lesions in the lower extremities, cutaneousmucous icterus, lymphadenopathy, asthenia, and a fever of 388C. The emergency analysis was as follows. Leukocytes numbered 11.5310...

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Contact dermatitis to antituberculosis drugs

Cited by 15 publications

References 23 publications

Hypersensitivity syndrome from isoniazid with positive patch test

Hypersensitivity syndrome from isoniazid with positive patch test

Erythema Multiforme–like Dermatitis Due to Isoniazid Hypersensitivity in a Patient With Psoriasis

Hypersensitivity syndrome from isoniazid

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