Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form

Yamamoto, Mami; Miyai, Masahiro; Matsumoto, Yuuko; Tsuboi, Ryoji; Hibino, Toshihiko

doi:10.1074/jbc.m112.357467

Cited by 32 publications

(32 citation statements)

References 37 publications

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“…Mesotrypsin(ogen) was detected strongly in stratum granulosum (SG). These findings are in accordance with previous reports (6,7). The presence of these proteases and saposin A at the granular layer indicates that this may be the site of saposin A generation.…”

Section: Lc/ms/ms Analysis Of Caspase-14 Interacting Molecules-supporting

confidence: 94%

“…It is not yet clear whether KLK7 is also involved in this reaction. However, the fact that KLK7 is able to activate procaspase-14 (6) suggests that it may have a role in prosaposin processing.…”

Section: Discussionmentioning

confidence: 99%

“…GST fusion proteins were purified by means of glutathione-agarose (Qiagen) affinity chromatography. Constitutively active caspase-14 (revC14) and the intermediate form of caspase-14 (revC14-Y178) were constructed using pET15b vector (Novagen) as reported earlier (6). These recombinant proteins were isolated with nickel-agarose and further purified with MonoQ chromatography.…”

Section: Methodsmentioning

confidence: 99%

“…Activation of caspase-14 occurs at the onset of corneocyte formation (5). We have shown that caspase-14 is completely different from other caspases, being regulated by kallikrein-related peptidase-7 (KLK7) and an intermediate form of caspase-14 (6). KLK7 cleaves procaspase-14 at Tyr-178, transiently generating an intermediate form (p20/p8).…”

mentioning

confidence: 99%

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Mesotrypsin and Caspase-14 Participate in Prosaposin Processing

Yamamoto-Tanaka

Motoyama

Miyai

et al. 2014

Journal of Biological Chemistry

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Background:The mechanism of prosaposin processing to generate saposins A-D is unknown. Results: Epidermis-specific mesotrypsin and caspase-14 generated mature saposins from prosaposin. Deficiency of prosaposin or saposin A resulted in loss of intercellular lipid components necessary for maintenance of skin permeability barrier properties. Conclusion: Mesotrypsin and caspase-14 are involved in prosaposin processing. Significance: Saposin generation in epidermis is regulated in a differentiation-associated manner.

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Section: Lc/ms/ms Analysis Of Caspase-14 Interacting Molecules-supporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Mesotrypsin and Caspase-14 Participate in Prosaposin Processing

Yamamoto-Tanaka

Motoyama

Miyai

et al. 2014

Journal of Biological Chemistry

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“…Indeed, previous studies have shown a reduced binding between this C622G mutant and HDAC1, while its association with the vitamin D receptor (VDR) was not hampered (14). Caspase-14 processing occurs during cornification at the transition zone between granular and cornifying layers (9,21). Therefore, the fact that besides the proenzyme, also processed forms of caspase-14 are increased in SKH1 skin, could be due to the increased cornification observed in the utricle in SKH1 mice compared to the infundibulum in wild-type mice.…”

Section: Discussionmentioning

confidence: 97%

Caspase‐14 overexpression in hairless mice is not involved in utricle formation

Devos

Groote

Gilbert

et al. 2013

Experimental Dermatology

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In conclusion, clinical diagnosis is important, but insufficient to detect AGA correctly. In the office, in the absence of other easy suitable criteria, MWT is a cheap, simple and reliable (8) method readily accepted by patients. Although easy to apply, TrichoScan â is expensive, and in TE and in AGA + TE, it may be even misleading. Author contributionsM Guarrera and MC Fiorucci performed the research; A Rebora designed the research study; A Rebora and M Guarrera analysed the data; and A Rebora wrote the manuscript. Conflict of interestsThe authors have declared no conflicting interests. (0)9 22 17673, e-mail: wim.declercq@dmbr.vib-UGent.be Abstract: Loss of functional hairless (HR) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase-14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase-14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase-14.However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation.

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Cornification

Eckhart

2018

Apoptosis and Beyond

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Kallikrein-related Peptidase-7 Regulates Caspase-14 Maturation during Keratinocyte Terminal Differentiation by Generating an Intermediate Form

Cited by 32 publications

References 37 publications

Mesotrypsin and Caspase-14 Participate in Prosaposin Processing

Mesotrypsin and Caspase-14 Participate in Prosaposin Processing

Caspase‐14 overexpression in hairless mice is not involved in utricle formation

Cornification

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