Caspase‐14 overexpression in hairless mice is not involved in utricle formation

Abstract

In conclusion, clinical diagnosis is important, but insufficient to detect AGA correctly. In the office, in the absence of other easy suitable criteria, MWT is a cheap, simple and reliable (8) method readily accepted by patients. Although easy to apply, TrichoScan â is expensive, and in TE and in AGA + TE, it may be even misleading. Author contributionsM Guarrera and MC Fiorucci performed the research; A Rebora designed the research study; A Rebora and M Guarrera analysed the data; and A Rebora wrote the manuscript. Conflict of interestsThe authors have declared no conflicting interests. (0)9 22 17673, e-mail: wim.declercq@dmbr.vib-UGent.be Abstract: Loss of functional hairless (HR) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase-14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase-14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase-14.However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation.

The skin microbiome of caspase‐14‐deficient mice shows mild dysbiosis

“…Caspase‐14, unlike the ubiquitously expressed apoptotic caspases, is processed and activated mainly in the suprabasal layers of the epidermis and the hair follicle . Biochemical experiments and the development of caspase‐14 deficient mice proved that caspase‐14 is involved in the degradation of filaggrin during cornification.…”