Global environmental problems such as climate change, natural disasters, energy consumption, and biodiversity are among the main concerns of the countries. Approximately 50% of the energy consumed worldwide is spent on architectural constructions. The increase in energy consumption, especially in buildings, has brought energy efficiency and reduction of carbon footprint to the fore. There are many factors in determining energy consumption in buildings such as physical environment, climate, orientation, shell, and material properties. Energy consumption can be increased in order to provide indoor climatic comfort in winter and summer periods. This study aimed to investigate the energy consumption and comfort conditions of a boutique hotel in Abdera, Greece. ArchiCAD, Graphisoft, EcoDesigner software were used in the analysis of findings, and suggestions were put forward. We suggest that the effective use of natural resources in terms of individual, urban, social, and global perspectives will be positively influenced by the reduction of energy consumption without compromising comfort conditions in accommodation buildings.