This study aims to determine the development and effectiveness of STEM in biology learning, referring to the development of STEM in science in Indonesia. This research is a literature study that examines some research articles that are compatible with the research theme. The research sample was taken purposively based on items related to the research theme, the research journal articles used came from searches on google scholar data, totaling 45 articles with a range of the last five years (2016)(2017)(2018)(2019)(2020). The results of this study indicate that the most widely conducted research is to test the impact, influence, or effectiveness of 55.56%, the most commonly used research design is the quasi-experimental 44.90%, the data collection technique uses the 51.47% test, the most data analysis using N-gain 33.33%, the learning model that is most integrated with STEM is PjBL 31.11%, the effectiveness of STEM application in biology learning is dominated by the effectiveness of increasing learning outcomes 20%, 18% creative thinking, 14% understanding of concepts. Based on the analysis of the results, it can be projected that STEM will also be able to improve critical thinking skills,