Kainic acid lesions of the superior olivary complex: a horseradish peroxidase study of surviving brain-stem projections

Rooney, B.J.; Kavanagh, Gerard L.; Kelly, Jack B.

doi:10.1016/0165-0270(91)90094-g

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…The injection technique was modeled after a procedure that lesions the superior olivary complex (SOC) via injection of kainic acid (KA) into the brain stem. Those experiments were conducted in guinea pigs (Gardi and Bledsoe 1981;Bledsoe et al 1990), rats (e.g., Li and Kelly 1992;Sally and Kelly 1992), ferrets (Rooney et al 1991), and cats (Zaaroor and Starr 1991). One drawback to experiments in which KA is used to lesion the brain stem is that KA injection produces broad damage.…”

Section: Introductionmentioning

confidence: 99%

Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses

Prell

Shore

Hughes

et al. 2003

JARO

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The functional consequences of selectively lesioning the lateral olivocochlear efferent system in guinea pigs were studied. The lateral superior olive (LSO) contains the cell bodies of lateral olivocochlear neurons. Melittin, a cytotoxic chemical, was injected into the brain stem using stereotaxic coordinates and near-field evoked potentials to target the LSO. Brain stem histology revealed discrete damage to the LSO following the injections. Functional consequences of this damage were reflected in depressed amplitude of the compound action potential of the eighth nerve (CAP) following the lesion. Threshold sensitivity and N1 latencies were relatively unchanged. Onset adaptation of the cubic distortion product otoacoustic emission (DPOAE) was evident, suggesting a reasonably intact medial efferent system. The present results provide the first report of functional changes induced by isolated manipulation of the lateral efferent pathway. They also confirm the suggestion that changes in single-unit auditory nerve activity after cutting the olivocochlear bundle are probably a consequence of disrupting the more lateral of the two olivocochlear efferent pathways.

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Section: Introductionmentioning

confidence: 99%

Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses

Prell

Shore

Hughes

et al. 2003

JARO

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“…The purpose of the present study was to investigate the sound localization ability of rats following either unilateral or bilateral lesions of the DNLL. Psychometric performance curves and minimum audible angles (MAAs) for midline sound localization were determined before and after DNLL lesions induced by local injection of kainic acid, an excitatory amino acid analog that destroys cell bodies in the auditory brainstem without damaging fibers of passage (Masterton, Glendenning, & Hutson, 1979; Rooney, Kavanagh, & Kelly, 1991).…”

mentioning

confidence: 99%

Sound localizations after kainic acid lesions of the dorsal nucleus of the lateral lemniscus in the albino rat.

Kelly¹,

Li²,

Adel³

1996

Behavioral Neuroscience

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The ability of rats to localize sounds in space was determined before and after kainic acid lesions of the dorsal nucleus of the lateral lemniscus (DNLL). The rats were trained to approach a 45-ms noise burst delivered from loudspeakers on the right or left of midline. Lesions were made by local injection of kainic acid into the DNLL. Rats with unilateral lesions of DNLL were impaired in their postoperative ability to localize a single noise burst. Rats with bilateral lesions also had deficits in postoperative performance, but the severity of the impairment was not substantially greater than that expected from a unilateral lesion. The mean pre- and postoperative minimum audible angles were 14.8 degrees and 40.4 degrees for rats with complete unilateral lesions and 13.5 degrees and 36.0 degrees for rats with bilateral lesions.

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“…Although these lesions undoubtedly do disrupt binaural processing in the SOC, they might also disrupt binaural mechanisms in more rostrally located structures that are also innervated via the trapezoid body. Kavanagh and Kelly (1992) have shown that deficits in sound localization by ferrets occur even if SOC lesions are induced by local injection of the neurotoxin, kainic acid, an excitatory amino acid analog that destroys neurons but spares decussating fibers in the auditory lower brainstem (Masterton et al 1979;Rooney et al 1991). In this case, impairments in sound localization can be attributed specifically to the destruction of the SOC and its immediate connections rather than disruption of fibers of passage that innervate more rostral structures (Kavanagh & Kelly, 1987;Kelly & Kavanagh, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…In cats, surgical destruction of the SOC or transections of the decussating fibers in the trapezoid body result in severe impairments in the ability of animals to localize sounds in space (Casseday & Neff, 1975; Jenkins & Masterton, 1982; Masterton, Jane, & Diamond, 1967; Moore et al, 1974). Although the inter pretation of these studies is complicated by the possibility that the lesions disrupt projections in the auditory brainstem that normally bypass the SOC and target more rostral struc tures, Kavanagh and Kelly (1992) have shown that kainic acid lesions of the SOC in the ferret result in severe sound localization deficits even though the fibers of passage remain intact (Rooney, Kavanagh, & Kelly, 1991). Thus, deficits in sound localization are apparent even when the lesions are restricted to the local circuitry and projections of the SOC.…”

mentioning

confidence: 99%

Kainic acid lesions of the superior olivary complex: Effects on sound localization by the albino rat.

Adel¹,

Kelly²

1998

Behavioral Neuroscience

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The ability of rats to localize sounds in space was determined before and after kainic acid lesions of the superior olivary complex (SOC). Animals were tested with a 45-ms noise burst delivered from loudspeakers on the right or left of midline. Anatomical data showed that the lesions destroyed neurons in SOC while preserving fibers of passage in the trapezoid body and other decussating pathways of the auditory brainstem. Animals with either unilateral or bilateral SOC lesions were impaired in their ability to localize a single noise burst postoperatively. Deficits were also found after unilateral lesions restricted primarily to the lateral superior olive. SOC lesions resulted in an elevation in minimum audible angles for sound localization.

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Kainic acid lesions of the superior olivary complex: a horseradish peroxidase study of surviving brain-stem projections

Cited by 11 publications

References 25 publications

Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses

Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses

Sound localizations after kainic acid lesions of the dorsal nucleus of the lateral lemniscus in the albino rat.

Kainic acid lesions of the superior olivary complex: Effects on sound localization by the albino rat.

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