Kainic acid lesions of the superior olivary complex: Effects on sound localization by the albino rat.

Adel, Brian A. van; Kelly, Jack B.

doi:10.1037/0735-7044.112.2.432

Cited by 21 publications

(8 citation statements)

References 56 publications

(92 reference statements)

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“…Not surprisingly, lesions of the SOC lead to behavioral deficits and alterations of cellular responses at other levels of the auditory system (e.g., Casseday and Neff, 1975;Jenkins and Masterton, 1982;Kavanagh and Kelly, 1992;Kelly and Sally, 1993;Li and Kelly, 1992;Masterton et al, 1967;Sally and Kelly, 1992;van Adel and Kelly, 1998). At the same time, it must be recalled that not all auditory information travels through the SOC.…”

Section: Resultsmentioning

confidence: 99%

Afferent projections of the superior olivary complex

Thompson

Schofield

2000

Microsc. Res. Tech.

137

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Section: Resultsmentioning

confidence: 99%

Afferent projections of the superior olivary complex

Thompson

Schofield

2000

Microsc. Res. Tech.

137

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“…Studies on human subjects show that our ability to resolve the direction of high frequency sounds depends on ILD [2]. Animal subjects with unilateral lesions at different structures of the central auditory pathway, including the cochlea, superior olivary complex (SOC), lateral lemniscus (LL), inferior colliculus (IC), medial geniculate body, and auditory cortex, all have difficulties identifying the location of the sound source [3], [4]. Invasive electrical recording studies have also been used to provide information on the neural mechanisms of sound localization.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive fMRI Investigation of Interaural Level Difference Processing in the Rat Auditory Subcortex

et al. 2013

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ObjectiveInteraural level difference (ILD) is the difference in sound pressure level (SPL) between the two ears and is one of the key physical cues used by the auditory system in sound localization. Our current understanding of ILD encoding has come primarily from invasive studies of individual structures, which have implicated subcortical structures such as the cochlear nucleus (CN), superior olivary complex (SOC), lateral lemniscus (LL), and inferior colliculus (IC). Noninvasive brain imaging enables studying ILD processing in multiple structures simultaneously.MethodsIn this study, blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is used for the first time to measure changes in the hemodynamic responses in the adult Sprague-Dawley rat subcortex during binaural stimulation with different ILDs.Results and SignificanceConsistent responses are observed in the CN, SOC, LL, and IC in both hemispheres. Voxel-by-voxel analysis of the change of the response amplitude with ILD indicates statistically significant ILD dependence in dorsal LL, IC, and a region containing parts of the SOC and LL. For all three regions, the larger amplitude response is located in the hemisphere contralateral from the higher SPL stimulus. These findings are supported by region of interest analysis. fMRI shows that ILD dependence occurs in both hemispheres and multiple subcortical levels of the auditory system. This study is the first step towards future studies examining subcortical binaural processing and sound localization in animal models of hearing.

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“…Neurons in the lateral superior olive are sensitive to interaural intensity differences, being excited by stimulation of the ipsilateral ear and suppressed by stimulation of the contralateral ear (4). These neurons are thus referred to as ipsi-excitation and contrainhibition (E-I) neurons and play a key role in sound source localization (5).…”

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confidence: 99%

Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sources

Kikuta

Sato

Kashiwadani

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Rodents can localize odor sources by comparing odor inputs to the right and left nostrils. However, the neuronal circuits underlying such odor localization are not known. We recorded neurons in the anterior olfactory nucleus (AON) while administering odors to the ipsilateral or contralateral (ipsi-or contra-) nostril. Neurons in the AON pars externa (AONpE) showed respiration phase-locked excitatory spike responses to ipsinostril-only stimulation with a category of odorants, and inhibitory responses to contranostril-only stimulation with the same odorants. Simultaneous odor stimulation of the ipsi-and contranostrils elicited significantly smaller responses than ipsinostril-only stimulation, indicating that AONpE neurons subtract the contranostril odor inputs from ipsinostril odor inputs. An ipsilateral odor source induced larger responses than a centrally located source, whereas an odor source at the contralateral position elicited inhibitory responses. These results indicate that individual AONpE neurons can distinguish the right or left position of an odor source by referencing signals from the two nostrils.olfactory cortex | binasal inputs | odor localization

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Kainic acid lesions of the superior olivary complex: Effects on sound localization by the albino rat.

Cited by 21 publications

References 56 publications

Afferent projections of the superior olivary complex

Afferent projections of the superior olivary complex

Noninvasive fMRI Investigation of Interaural Level Difference Processing in the Rat Auditory Subcortex

Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sources

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