Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Luo, Cheng; Yang, Hui; Tang, Chengyong; Yao, Gaoqiong; Kong, Lingna; He, Haibo; Zhou, Yifei

doi:10.1016/j.intimp.2015.07.018

Cited by 135 publications

(80 citation statements)

References 36 publications

(52 reference statements)

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“…Similarly, kaempferol is another typical dietary flavonoid that was shown to have many beneficial activities including anti-diabetic, antioxidant, and anti-inflammatory through promoting functions of pancreatic β-cell [37]. It was also shown to have positive effect on lipid metabolism, stimulate insulin-dependent glucose uptake and improve insulin resistance [38]. Chlorogenic acid, one of the most abundant polyphenol compounds in the human diet was also identified by us in AMAF.…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Potential of the Leaves of Anisomeles malabarica in Streptozotocin Induced Diabetic Rats

Kotha

Badri

Nagalapuram

et al. 2017

Cell Physiol Biochem

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Background/Aims: Diabetes mellitus is a pandemic metabolic disorder that is affecting a majority of populations in recent years. There is a requirement for new drugs that are safer and cheaper due to the side effects associated with the available medications. Methods: We investigated the anti-diabetic activity of leaves of Anisomeles malabarica following bioactivity guided fractionation. The different solvent (hexane, ethyl acetate, methanol and water) extracts of A. malabarica leaves were used in acute treatment studies to evaluate and identify the active fraction. The ethyl acetate extract was subjected to further fractionation using silica gel column chromatography and the compounds were identified by LC-SRM/MS and GC-MS. Additional chronic treatment studies were carried out using this active fraction (AMAF) for 30 days in experimental diabetic rats. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), plasma insulin levels and glucose tolerance were measured along with insulin resistance/sensitivity indicators (HOMA-IR, HOMA-β and QUICKI) to assess the beneficial effects of A. malabarica in the management of diabetes mellitus. Results: Among the different solvent extracts tested, ethyl acetate extract showed maximum (66%) anti-hyperglycemic activity. The hexane and ethyl acetate (1: 1) fraction that has maximum anti-diabetic activity was identified as active fraction of A. malabarica (AMAF). The FBG, HbA1c, plasma insulin levels and insulin sensitivity/resistance indicators such as glucose tolerance, HOMA-IR, HOMA-β and QUICKI were significantly improved to near normal in diabetic rats treated with AMAF. Further, we identified key flavonoids and fatty acids as the anti-diabetic active principles from the AMAF of A. malabarica leaves. Conclusion: The results of our study suggest that Anisomeles malabarica has potential anti-diabetic activity in STZ induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Potential of the Leaves of Anisomeles malabarica in Streptozotocin Induced Diabetic Rats

Kotha

Badri

Nagalapuram

et al. 2017

Cell Physiol Biochem

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“…19,20) Intake of kaempferol ameliorates hyperglycemia, hyperinsulinemia and circulating lipid profile, which are associated with improved peripheral insulin sensitivity in mice fed a high-fat diet. 21,22) Upregulation of carnitine palmitoyltransferase 1 by p-coumaric acid improves liver fat metabolism. 23) Further studies are needed to clarify what components are effective for weight control.…”

Section: )mentioning

confidence: 99%

Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet

Sakai

Ohhata

Fujii

et al. 2017

Biological & Pharmaceutical Bulletin

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Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption.

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“…It is a very well-known to possess antioxidant [107] antiinflammatory [108] , anticancer, [109] neuroprotective [110] and anti-diabetic properties. [111] Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Mechanism of Flavonoids Action in Smooth Muscle Relaxation

Basir¹

2017

WJPPS

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Hyper contraction of Smooth Muscle is related to various diseases like hypertension, asthma, coronary resistance. Most of the contractile pathways are related to endothelial dysfunction and rise in extracellular calcium. To counter the hyper contractile response of smooth muscles flavonoids act as relaxant molecules or inhibitors of contraction. In this paper we have reviewed the mechanism of action of some known flavonoids such as quercetin, Galetin 3-6-dimethyle ether, kaempferol, fisetin, catechin, apaginin wogonin, naringeinin, formonontin, genistein, daidzen, ayanin, pulicarin. These compounds show endothelium dependent relaxation and play role in enhancing nitric oxide (NO) and endothelium independent relaxation by blocking calcium channels and potassium channels.We have not limited our literature survey to organ bath related research papers but we have included both invivo and invitro studies in this review so that this review may help researcher to make correlation between both studies.

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Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Cited by 135 publications

References 36 publications

Anti-Diabetic Potential of the Leaves of Anisomeles malabarica in Streptozotocin Induced Diabetic Rats

Anti-Diabetic Potential of the Leaves of Anisomeles malabarica in Streptozotocin Induced Diabetic Rats

Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet

Mechanism of Flavonoids Action in Smooth Muscle Relaxation

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