Kadsuphilactones A and B, Two New Triterpene Dilactones from Kadsura philippinensis

Abstract

[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

“…Some of the seco -cycloartanes have reported to have anti-HIV-1 activity [29] and anti-HBV (hepatitis B virus) activity [30]. The earliest example was nigranoic acid from stems of Schisandra sphaerandra that has been demonstrated to be capable of inhibiting HIV viral reverse transcriptase with IC 50 = 74.1  μ g/mL [31].…”

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

“…Phytochemical investigations on species of the family Schisandraceae have revealed that they are rich sources of lignans, which possessed various beneficial pharmacological effects, such as antitumor, 1 cytotoxic, [2][3][4] anti-HIV, 5,6 antioxidative, 7,8 antihepatitis, 9 and hepatoprotective effects. 1 Schisandra propinqua var.…”

Four New Dibenzocyclooctadiene Lignans from Schisandra rubriflora

“…Therefore, the other Me group at 0.89 (d, J ¼ 6.8) was assigned to Me (17) irreproachably. The HMBC correlations from one OÀCH 2 ÀO group (d(H) 5.93) to C(12) and C (13), from the other OÀCH 2 ÀO group (d(H) 6.00) to C(2) and C(3), and from two MeO groups to C(1) and C (14) indicated the arrangement of the substituents on the biphenyl rings of 1 was the same as that of gomisin R (5) [17]. The location of the two MeO groups was further confirmed by the ROESY correlations (Fig.…”