[1] Data from a DPS-4 Digisonde and an ionospheric scintillation monitor, both located at the low-latitude station Hainan (109.1°E, 19.5°N; dip latitude 9°N), were analyzed to study the strong range spread F (SSF) and its correlation with ionospheric scintillations observed in the period of declining solar cycle 23 from 2003 to 2007. The results show that the maximum and minimum of the occurrence of SSF appeared in nearly the same months as those of the GPS L band scintillations. The variations in SSF occurrence were also similar to those of the scintillations. From 2003 to 2007, both the SSF and the scintillation occurrences decreased from the high solar activity year to the low solar activity year. The correlation coefficient between the occurrences of the SSF and the GPS L band scintillation was as high as 0.93, suggesting associated mechanisms producing SSF and scintillations. Electron density depletions extending from the bottomside to the topside ionosphere are the likely cause explaining the high correlation.

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A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C(9) side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC(50) value of 47.91 and 32.66 μg/mL, respectively.

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Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The absolute configuration of 1 was determined by spectral methods and single crystal X-ray diffraction analysis. Compound 4 and the synthesized compound 5 exhibited significant cytotoxicity.

Abstract. The temporal variations of the low latitude nighttime spread F (SF) observed by DPS-4 digisonde at low latitude Hainan station (geog. 19.5 • N, 109.1 • E, dip lat. 9.5 • N) during the declining solar cycle 23 from March 2002 to February 2008 are studied. The spread F measured by the digisonde were classified into four types, i.e., frequency SF (FSF), range SF (RSF), mixed SF (MSF), and strong range SF (SSF). The statistical results show that MSF and SSF are the outstanding irregularities in Hainan, MSF mainly occurs during summer and low solar activity years, whereas SSF mainly occurs during equinoxes and high solar activity years. The SSF has a diurnal peak before midnight and usually appears during 20:00-02:00 LT, whereas MSF peaks nearly or after midnight and occurs during 22:00-06:00 LT. The time of maximum occurrence of SSF is later in summer than in equinoxes and this time delay can be caused by the later reversal time of the E ×B drift in summer. The SunSpot Number (SSN) dependence of each type SF is different during different season. The FSF is independent of SSN during each season; RSF with SSN is positive relation during equinoxes and summer and is no relationship during the winter; MSF is significant dependence on SSN during the summer and winter, and does not relate to SSN during the equinoxes; SSF is clearly increasing with SSN during equinoxes and summer, while it is independent of SSN during the winter. The occurrence numbers of each type SF and total SF have the same trend, i.e., increasing as Kp increases from 0 to 1, and then decreasing as increasing Kp. The correlation with Kp is negative for RSF, MSF, SSF and total SF, but is vague for the FSF.

Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 μg ml(-1) and therapeutic index value of 117.12.

This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 approximately 20.4 microg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.