Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Shang, Shan‐Zhai; Han, Ying-Shan; Shi, Yiming; Du, Xue; Liang, Cheng-Qin; Wainberg, Mark A.; Gao, Zhong‐Hua; Xiao, Wei‐Lie; Sun, Han‐Dong

doi:10.1007/s13659-013-0017-8

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…The family Schisandraceae, including genera Schisandra and Kadsura, is a medicinally important plant taxon widely distributed in Southeastern Asia and Southeastern America. Previous phytochemical investigations on Schisandraceae species have led to the discovery of an array of structurally diverse natural products, including lignans [1,2], triterpenoids [3][4][5][6], sesquiterpenoids [7,8], etc. These compounds were found to exhibit various beneficial biological functions, including anti-HIV activity [9], hepatoprotective activity [1,10], anti-hepatitis activity [11], neuroprotective activity [6,12], inhibitory activity on proliferation of rheumatoid arthritis-fibroblastoid synovial cells [13], and so on.…”

Section: Introductionmentioning

confidence: 99%

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Zhang

et al. 2022

Nat. Prod. Bioprospect.

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A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Zhang

et al. 2022

Nat. Prod. Bioprospect.

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Plant-derived lignans as potential antiviral agents: a systematic review

Wang

et al. 2021

Phytochem Rev

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Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have even been developed as therapeutic drugs. In this review, 630 lignans, including those obtained from medicinal plants and their chemical derivatives, were systematically reviewed for their antiviral activity and mechanism of action. The compounds discussed herein were published in articles between 1998 and 2020. The articles were identified using both database searches (e.g., Web of Science, Pub Med and Scifinder) using key words such as: antiviral activity, antiviral effects, lignans, HBV, HCV, HIV, HPV, HSV, JEV, SARS-CoV, RSV and influenza A virus, and directed searches of scholarly publisher’s websites including ACS, Elsevier, Springer, Thieme, and Wiley. The compounds were classified on their structural characteristics as 1) arylnaphthalene lignans, 2) aryltetralin lignans, 3) dibenzylbutyrolactone lignans, 4) dibenzylbutane lignans, 5) tetrahydrofuranoid and tetrahydrofurofuranoid lignans, 6) benzofuran lignans, 7) neolignans, 8) dibenzocyclooctadiene lignans and homolignans, and 9) norlignans and other lignoids. Details on isolation and antiviral activities of the most active compounds within each class of lignan are discussed in detail, as are studies of synthetic lignans that provide structure–activity relationship information.

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Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis

et al. 2021

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Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Cited by 5 publications

References 18 publications

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

Plant-derived lignans as potential antiviral agents: a systematic review

Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis

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