Kadar Superoksida Dismutase (SOD ) Pada Paru-Paru Tikus Hipertensi Doca-Garam Yang Dipapar Ekstrak Metanolik Benalu Teh Dan Benalu Mangga

Aini, Siti Qurrotul; Sjakoer, Nour Athiroh Abdoes; Mubarakati, Nurul Jadid

doi:10.24843/metamorfosa.2021.v08.i02.p13

Cited by 3 publications

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“…Hal tersebut membuktikan bahwa flavonoid menghambat aktivitas Angiotensin-Converting-Enzyme (ACE) (Athiroh AS & Permatasari, 2012). Pada penelitian yang telah dilakukan Aini et al, (2021)…”

Section: Pembahasanunclassified

“…Pada penelitian yang telah dilakukan Aini et al, (2021) sebelumnya telah membuktikan bahwa ekstrak metanol benalu teh dan benalu mangga dapat meningkatkan kadar SOD paru pada tikus model hipertensi yang diinduksi DOCA-Garam pada penelitian dengan model kuratif. Peningkatan SOD dan penurunan MDA mampu memperbaiki stres oksidatif melalui pemberian ekstrak metanol benalu teh dan benalu mangga yang berperan sebagai antioksidan.…”

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Paparan benalu (teh dan mangga) terhadap kadar Superoksida Dismutase (SOD) serum tikus hipertensi model preventif

Mufida¹,

Sjakoer

Mubarakati

2022

JBIOUNUD

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Salah satu penyakit yang menjadi masalah kesehatan karena terjadi peningkatan prevalensi setiap tahunnya adalah penyakit hipertensi. Tingginya ROS (Reactive Oxygen Species) dalam tubuh akan meningkatkan pembentukan radikal bebas berlebih dan membuat antioksidan endogen SOD (Superoxide dismutase) terpakai secara berlebih sehingga menjadi penyebab munculnya penyakit hipertensi. Tanaman herbal benalu teh dan benalu mangga merupakan tumbuhan yang memiliki potensi sebagai pencegahan hipertensi dengan meningkatkan aktivitas SOD dalam tubuh. Tujuan penelitian ini untuk mengetahui pengaruh pemaparan ekstrak metanol kombinasi benalu teh dan benalu mangga (EMKBTBM) terhadap peningkatan kadar SOD serum pada tikus hipertensi yang diinduksi DOCA-Garam menggunakan model preventif. Pada penelitian ini menggunakan metode eksperimental dengan hewan uji berjumlah 25 ekor tikus wistar jantan yang terbagi menjadi 5 kelompok dan terdapat 5 ekor tikus pada setiap kelompok, yaitu kontrol negatif (K-), kontrol positif (K+), dan kelompok dengan perlakuan pemaparan EMKBTBM (P1) dosis 50 mg/kgBB, (P2) dosis 100 mg/kgBB, dan (P3) dosis 200 mg/kgBB. Didapatkan hasil penelitian yang menunjukkan bahwa pemaparan EMKBTBM berpengaruh terhadap peningkatan aktivitas SOD serum pada tikus hipertensi dengan perbedaan yang signifikan pada nilai reratanya antar semua kelompok dengan nilai p <0,05. Efektivitas pengaruh pemaparan benalu teh dan benalu mangga dikendalikan oleh EMKBTBM dosis 100 mg/KgBB yang merupakan dosis efektif dalam meningkatkan kadar SOD serum tikus model hipertensi DOCA-Garam.

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“…Hal tersebut membuktikan bahwa flavonoid menghambat aktivitas Angiotensin-Converting-Enzyme (ACE) (Athiroh AS & Permatasari, 2012). Pada penelitian yang telah dilakukan Aini et al, (2021)…”

Section: Pembahasanunclassified

unclassified

Paparan benalu (teh dan mangga) terhadap kadar Superoksida Dismutase (SOD) serum tikus hipertensi model preventif

Mufida¹,

Sjakoer

Mubarakati

2022

JBIOUNUD

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“…Mango mistletoe (Dendrophthoe pentandra (L.) Miq) can be utilized as one of herbal plants that produce high antioxidants [6]. Studies have found that mango mistletoe has potential medicinal benefits, such as treating hypertension [7,8,9], diabetes, cancer [10], infections, and promoting diuresis. Other studies also state that mango mistletoe leaves have antioxidant activity and contain flavonoids, saponins, polyphenols, and tannins [11].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Assay of Endophytic Fungi Extract from Mango Mistletoe (Dendrophthoe pentandra (L.) Miq) Leaves

‘Aini

2023

JSMARTech

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Endophytic fungi found in mango mistletoe (Dendrophthoe pentandra (L.) Miq) leaves may potentially create a variety of bioactive antioxidant compounds, and their prospects for large-scale production especially for phytopharmaceuticals products without excessive natural exploitation. The objective of this study was to investigate the antioxidant properties of endophytic fungal extracts obtained from mango mistletoe leaves. The method used is experimental laboratory research with a quantitative approach through the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity method. The test sample concentrations ranged from 120 µg/ml to 200 µg/ml. The results of this study indicated that isolates of EFMM 1 (Aspergillus spp.) has an IC50 of -12,27 µg/ml, EFMM 2 (Neurospora spp.) has an IC50 of 10,40 µg/ml, EFMM 3 (Hormiscium spp.) has an IC50 of 49,44 µg/ml, and EFMM 4 (Exserohillum spp.) has an IC50 of 299,32 µg/ml. The conclusion is that EFMM 1 doesn't have an antioxidant activity, while EFMM 2 has the highest antioxidant potential comparable to ascorbic acid.

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The Effect of Tea Epiphyte (Scurrula atropurpurea BI. Dans) and Mango Epiphyte (Dendrophthoe petandra) Combination on CD4, CD8, IL-10, and TNF-α Levels in Hypertension Rats

Sjakoer

Purnomo

2022

Biomed. Pharmacol. J.

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Hypertension is a degenerative disease that become health problem in the world. S. atropurpurea BI. Dans and D. petandra are herbs that showed anti-hypertension activity. However, the potency of their combination onimmune system in hypertension condition have not been explored completely. The study aim to examine effect of S. atropurpurea BI. Dans and D. petandra combination on Cluster of Differentiation 4 (CD4), Cluster of Differentiation 8(CD8), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF- α) level in hypertension rats. The rat was administrated orally with methanolic extract of S. atropurpurea BI. Dans and D. petandra (1:3) combination at dose of 50 mg/kgBW (P1), 100 mg/kgBW (P2) and 200 mg/kgBW (P3) for four weeks. Hypertension rats are induced with Deoxycorticosterone acetate (DOCA) and salt orally at the second weeks after herbs administration. Blood sample was collected from intra cardiac, furthermore, the level of IL-10 and TNF-α levels are examined using the Enzyme-linked immunosorbent assay (ELISA) method, whereas CD4 and CD8 levels are examined using flow cytometri. The data was analyzed using ANOVA test continued with LSD test (p < 0,05). The treatment groups (PI, P2, and P3) showed an increase of CD4 levels more and less 3 times,10 times, and 8 times respectively; an increase of CD8 level about 2 times, 3 times, and 2 times respectively compare to hypertension group (p<0.05). However, IL-10 level were increased only by P3 group (p<0.05). Meanwhile, the combination of herbsdecreased TNF-α level approximately 50-60% for three doses used (p<0.05). Combination of methanolic extracts of S. atropurpurea BI. Dans and D. petandra increase CD4, CD8 and IL-10 level and decreased TNF-α level on hypertension rat.

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Kadar Superoksida Dismutase (SOD ) Pada Paru-Paru Tikus Hipertensi Doca-Garam Yang Dipapar Ekstrak Metanolik Benalu Teh Dan Benalu Mangga

Cited by 3 publications

References 0 publications

Paparan benalu (teh dan mangga) terhadap kadar Superoksida Dismutase (SOD) serum tikus hipertensi model preventif

Paparan benalu (teh dan mangga) terhadap kadar Superoksida Dismutase (SOD) serum tikus hipertensi model preventif

Antioxidant Assay of Endophytic Fungi Extract from Mango Mistletoe (Dendrophthoe pentandra (L.) Miq) Leaves

The Effect of Tea Epiphyte (Scurrula atropurpurea BI. Dans) and Mango Epiphyte (Dendrophthoe petandra) Combination on CD4, CD8, IL-10, and TNF-α Levels in Hypertension Rats

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