Abstract:Latar belakang : Klonidin ketika digunakan bersamaan dengan obat lokal anestesi sebagai teknik regional anestesi, bisa mengurangi kejadian nyeri kronik pasca operasi. Sensitisasi perifer dan sensitisasi sentral merupakan salah satu mekanisme terjadinya transisi nyeri akut menjadi nyeri kronik. Kaskade awal yang menyebabkan sensitisasi perifer dan sensitisasi sentral di picu oleh pelepasan neurotransmitter eksitatorik presinaptik dan pasca sinaptik seperti glutamat dan substansi P.Tujuan : Membandingkan pening… Show more
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