Nimotuzumab is an anti group of anti-epidermal growth factor receptor the EGF protein receptor, such as colorectal, brain, pancrea cervical and breast cancer. In order to obtain a of the above-mentioned cancers, nimotuzumab and gamma-emitter 177 Lu. This report discuss vivo tests, which included cytotoxicity, clearance, imaging and biodistribution tests. The cytotoxicity test of (lung carcinoma) was found unradiolabeled nimotuzumab. The on normal rats showed that the residue the urine. The biodistribution and image tests showed that 177 Lu-DOTA-nimotuzumab there organs, such as the kidney, liver and bone post injection of 177 Lu-DOTA nearly the same as or slightly lower compared to other radiolabeled monoclonal antibodies, precautions still ha tested on cancer patients.
Abstract:The Sidoarjo mudflow in East Java, Indonesia, has been erupting since May 29 th , 2006. The eruption has been known as the Lusi (lumpur Sidoarjo), which was previously considered as a remote seismic event consequence, but current geyser-like activities show an association with a geothermal phenomenon. A method of characterizing rare earth elements (REE) is commonly an effective tool for recognizing a geothermal system, and here it is adapted to particularly indicate the environmental origin of the Lusi mud. Results show that the Lusi hot mud is made of a porous smectite structure of a shale rock type, which becomes an ideal tank for trapping the REE, especially the light REE. Volcanic activities seem to be an important influence in the eruption; however, since there is a lack of significant isotopic evidences in the mobilization of the REE during the eruption, the chloride neutral pH water of the Lusi may hardly contain the REE. The moderate Ce and Eu anomalies found in the REE patterns of the mud strongly indicate a sea-floor basin as the most probable environment for the REE fractionation during the sedimentary rock formation, in which the weathering processes of volcanic rock origin enriched the Lusi shale with the REE.
Penelitian ini menggunakan penelitian tindakan (action research) sebanyak tiga putaran. Setiap putaran terdiri dari empat tahap yaitu: rancangan, kegiatan dan pengamatan, refleksi, dan refisi. Sasaran penelitian ini adalah siswa Kelas II SD Negeri 3 Depok Kecamatan Bendungan Kabupaten Trenggalek semester I Tahun pelajaran 2012/2013. Dari hasil analis didapatkan bahwa metode diskusi memiliki dampak positif dalam meningkatkan prestasi belajar siswa.hal ini dapat dilihat dari semakin mantapnya pemahaman siswa terhadap materi yang disampaikan guru (ketuntasan belajar meningkat dari sklus I, II, dan III) yaitu masing-masing 64,00%, 80,00%, dan 88,00%. Kesimpulan dari penelitian ini adalah metode Diskusi mempunyai pengaruh positif, yaitu dapat meningkatkan motivasi belajar siswa.
This study aimed to compare the mechanical properties of the box-section beams made from laminated bamboo by strengthening the sidewall thickening. The base of this research was that the box-section beam had a higher bending strength than the solid cross-section with the same material volume but lack of shear strength due to the reduced sidewall thickening. A way to increase the shear strength of the box-section beam was to thicken the sidewall on the areas that receive the maximum shear force that was one-third of the span from both supports. In this research, the sidewall thickness variations in the maximum shear force areas were 2 cm (unreinforced group), 3 cm, 4 cm and 4.8 cm. The results of this research were; first, there was a significant increase in the shear strength of the box-section beam reinforced by the sidewall thickening compared to the unreinforced ones. Second, there was no significant difference in the modulus of elasticity of the box-section beams in all samples. Third, the average serviceability load of the box-section beams was 39.11% of the maximum load. And fourth, the sidewall thickening on one-third of the support span saved the material used compared to the thickening on the entire support span.
As we know, in the financial system, there are various financial institutions that act as financial intermediaries. That is, lending money from the savings and loan community, lending it back to other parties. This is because it does not rule out the possibility that credit will pose a risk for this research to assess how much non-performing loans are in terms of non-performing loans (NPL) in a banking company, namely PT Bank Mandiri (Persero) Tbk. The method used in this research is the descriptive method. The sources of data used are secondary data and the use of library research and observation techniques as data collection techniques. In this study, we used a non-performing loan (NPL) financial ratio calculator as a data analysis technique. From this study, it was concluded that the highest NPL ratio occurred in 2016 at 3.96% and the lowest NPL ratio occurred in 2019 at 2.39%. The average NPL for the 5 years starting from 2016-2020, which is 3.17%, is in the healthy predicate.
Price to Book Value (PBV) merupakan hubungan antara harga pasar saham dan nilai buku per lembar saham digunakan sebagai pendekatan alternatif untuk menentukan nilai suatu saham, karena secara teoritis, nilai pasar suatu saham haruslah mencerminkan nilai bukunya. Maksud penelitian ini untuk mengetahui gambaran umum mengenai tentang earning per share dan price to book value pada PT. Tri Banyan Tirta, Tbk. Sedangkan tujuan untuk mengetahui perkembangan earning per share, perkembangan price to book value dan seberapa besar pengaruh earning per share terhadap price to book value. Metode penelitian yang digunakan adalah metode kuantitatif deskriptif dan asosiatif. metode analisis yang digunakan terdiri dari earning per share menggunakan rumus eat dibagi jumlah saham yang beredar, price to book value menggunakan rumus harga saham perlembar dibagi book value, analisis korelasi sederhana, analisis koefisien determinasi, dan analisis regresi sederhana kemudian data diolah menggunakan program aplikasi SPSS versi 21. Data yang diambil berupa data sekunder yang diperoleh melalui Laporan Keuangan periode 2016-2019 dalam triwulan, dan beberapa kajian pustaka. Berdasarkan hasil penelitian perkembangan EPS berkisar antara 0,29% sampai 17,06%. Perkembangan PBV berkisar 1,46 kali sampai 2,42 kali, dan perkembangan EPS terhadap PBV pada PT. Tri Banyan Tirta, Tbk mengalami fluktuasi (naik-turun). Nilai korelasi sederhana sebesar 0,245 yang berarti EPS terhadap PBV mempunyai hubungan yang rendah. Sedangkan nilai koefisien determinasi sebesar 0,06 hal ini berarti PBV dipengaruhi EPS sebesar 6% dan sisanya dipengaruhi faktor-faktor lain. Dan regresi sederhana memperoleh persamaan Y = 1,882 +0,011X, dapat diartikan setiap peningkatan 1% EPS maka PBV akan naik sebesar 1,1%, dan apabila earning per share = 0 maka nilai price to book value sebesar 1,882.
Abstrak: Industri semen menyumbang hingga 8% dari seluruh emisi gas karbon dioksida secara global. Beton gradasi merupakan salah satu langkah untuk mereduksi penggunaan semen pada konstruksi sekaligus untuk mengoptimalkan karakteristik mekanik elemen struktur yang direncanakan. Penelitian ini bertujuan untuk menganalisis capaian beban maksimum, defleksi, kekakuan, daktilitas, dan pola kegagalan dari balok beton gradasi dengan variasi mutu beton pada serat tekan dan serat tariknya. Balok Balok gradasi terbuat dari perpaduan antara 2 (dua) campuran mutu yang berbeda, yaitu 30-40 MPa, 30-50 MPa, dan 40-50 MPa. Pengujian lentur balok beton dilakukan pada umur 28 hari. Pola kegagalan pada balok beton gradasi pada masing-masing benda uji diamati dan dikomparasikan dengan balok beton kontrol. Hasil pengujian menunjukkan bahwa balok beton gradasi dengan mutu beton pada serat tarik yang seragam menghasilkan beban, kekakuan, dan daktilitas balok yang lebih tinggi seiring peningkatan mutu beton yang digunakan pada serat tekannya. Balok dengan mutu beton serat tekan seragam dan serat tarik yang berbeda memiliki nilai capaian beban, kekakuan, dan daktilitas balok yang semakin besar seiring peningkatan mutu beton pada bagian serat tarik balok. Lendutan balok yang dihasilkan masih memenuhi lendutan izin. Berdasarkan hal tersebut, balok beton gradasi dinyatakan memiliki kemampulayanan yang baik.Kata-kata kunci: Balok Beton Gradasi, Kekakuan, Daktilitas, Pola KegagalanAbstract: The cement industry accounts for up to 8% of all global carbon dioxide emissions. Graded concrete is one of the steps to reduce the use of cement in construction as well as to optimize the mechanical characteristics of the planned structural elements. This study aims to analyze the maximum load performance, deflection, stiffness, ductility, and failure patterns of graded concrete beams with variations in the quality of concrete in the compression fiber and tensile fiber. Gradation beams are made from a combination of 2 (two) different quality mixtures, namely 30-40 MPa, 30-50 MPa, and 40-50 MPa. The flexural testing of the concrete beams was carried out at the age of 28 days. The failure pattern of the graded concrete beams for each test object was observed and compared with the control concrete beams. The test results show that graded concrete blocks with uniform tensile strength of concrete produce higher beam loads, stiffness, and ductility as the quality of the concrete used in compression fibers increases. Beams with uniform compression fiber and different tensile fibers have higher load, stiffness, and ductility values as the concrete quality increases in the tensile fiber portion of the beam. The resulting beam deflection still meets the allowable deflection. Based on this, the graded concrete beam is declared to have good serviceability.Keywords: Graded Concrete Beam, Stiffness, Ductility, Failure Pattern
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