Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management

Alvarez, Maria Saiz; Herrería-Bustillo, Vicente J; Utset, Artur Font; Martínez, Jorge

doi:10.5326/jaaha-ms-6283

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Results of our study suggest that the proportion of dogs with JDM in pure breed dogs is not different than the proportion of JDM in mixed breed dogs. Historically, JDM has also been reported in many different breeds [1,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. In this study, none of the owners or breeders of pure breed dogs with JDM were aware of other related dogs with JDM or mature inset DM.…”

Section: Plos Onementioning

confidence: 95%

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Seasonality and geography of diabetes mellitus in United States of America dogs

et al. 2022

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The diagnosis of type 1 diabetes mellitus (DM) in humans is associated with high altitude, few sunshine hours, cold climate, and winter. The goals of this study were to investigate seasonal and geographic patterns of DM diagnosis in United States of America (USA) dogs with juvenile and mature onset DM. Data were collected by means of an online survey widely distributed in the USA through breed clubs, academic veterinary institutions, private veterinary referral practices, social media outlets, and the American Kennel Club. Juvenile DM (JDM) and mature onset DM were defined as DM with an age of onset <365 days and DM with an age of onset ≥365 days, respectively. Meteorological seasons were defined as: winter from December through February, spring from March through May, summer from June through August, and fall from September through November. Four geographic regions were also defined as the West, North, South, and Central regions of the USA. Nonoverlapping 95% confidence intervals (CI) for season, geographic region, and breed specific proportions of dogs with JDM were considered statistically significantly different. The study included 933 dogs with mature onset DM and 27 dogs with JDM. Dogs were diagnosed with DM significantly more in the winter and northern USA compared to all other seasons and all other geographic regions, respectively. The prevalence of JDM among dogs with DM was 2.8%. The proportion of dogs with JDM among pure breeds was not significantly different than the proportion of JDM in mixed breed dogs. It is concluded that winter and cold climate could be shared environmental factors influencing DM expression in dogs and humans. Additionally, pure breed dogs do not appear to be at increased risk for JDM compared to mixed breed dogs, indicating that factors other than genetics could influence spontaneous JDM development in dogs.

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Section: Plos Onementioning

confidence: 95%

“…Juvenile DM is a rare condition in dogs and has been reported anecdotally in a small number of dogs [1,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. To the authors knowledge, this is the largest collection of dogs with JDM reported in the literature.…”

Section: Plos Onementioning

confidence: 99%

Seasonality and geography of diabetes mellitus in United States of America dogs

et al. 2022

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“…It has been revealed in the studies conducted on the dogs <12 months of age that concurrent occurrence of adolescent disease is an unusual event [ 11 , 12 ]. Besides, more than 70% of diagnosed female dogs cases suggest that they are highly predisposed to DM [ 7 ].…”

Section: Iddm Type-1 Diabetes In Dogsmentioning

confidence: 99%

“…DM in adolescence was infrequently characterized. The most diagnostic features such as hypoplasia of islets of Langerhans and blurred vision due to the diabetic bilateral cataract involving cortex and nucleus also help to classify DM in cats [ 12 ]. The symptoms of occurrence are similar with human’s diabetes; the diabetic cats persisted amyloid disease, damage to α-and β-cells, while normal δ-cells.…”

Section: Niddm Type-2 Diabetes In Catsmentioning

confidence: 99%

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Niaz¹,

Maqbool²,

Khan³

et al. 2018

Vet World

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Diabetes mellitus (DM) is a chronic metabolic disorder in which blood glucose level raises that can result in severe complications. However, the incidence increased mostly by obesity, pregnancy, persistent corpus luteum, and diestrus phase in humans and animals. This review has focused on addressing the possible understanding and pathogenesis of spontaneous DM in canine, feline, and few wild animals. Furthermore, pancreatic associated disorders, diabetic ketoacidosis, hormonal and drug interaction with diabetes, and herbal remedies associated with DM are elucidated. Bibliographic search for the present review was done using PubMed, Scopus, and Google Scholar for articles on concurrent DM in small and wild animals. Persistent corpus luteal and pseudopregnancy in female dogs generate gestational DM (GDM). GDM can also be caused by extensive use of drugs/hormones such as glucocorticosteroids. Although many similarities are present between diabetic cats and diabetic humans which present islet amyloidosis, there was a progressive loss of β- and α-cells and the normal number of δ-cells. The most prominent similarity is the occurrence of islet amyloidosis in all cases of diabetic cat and over 90% of human non-insulin dependent DM Type-2. Acute pancreatic necrosis (APN) occurs due to predisposing factors such as insulin antagonism, insulin resistance, alteration in glucose tolerance, obesity, hyperadrenocorticism, and persistent usage of glucocorticoids, as these play a vital role in the progression of APN. To manage such conditions, it is important to deal with the etiological agent, risk factors, diagnosis of diabetes, and hormonal and drug interaction along with its termination with suitable therapy (herbal) protocols. It should be noted that the protocols used for the diagnosis and treatment of human DM are not appropriate for animals. Further investigations regarding diabetic conditions of pets and wild animals are required, which will benefit the health status of all animals health worldwide.

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Etiology and Pathophysiology of Diabetes Mellitus in Dogs

O'Kell

Davison

2023

Veterinary Clinics of North America: Small Animal Practice

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Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management

Cited by 5 publications

References 11 publications

Seasonality and geography of diabetes mellitus in United States of America dogs

Seasonality and geography of diabetes mellitus in United States of America dogs

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Etiology and Pathophysiology of Diabetes Mellitus in Dogs

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