Judah Folkman, a pioneer in the study of angiogenesis

Abstract

More than 30 years ago, Judah Folkman found a revolutionary new way to think about cancer. He postulated that in order to survive and grow, tumors require blood vessels, and that by cutting off that blood supply, a cancer could be starved into remission. What began as a revolutionary approach to cancer has evolved into one of the most exciting areas of scientific inquiry today. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.

Correlation Between Microvessel Density and Morphological Features in Skin Squamous Cell Carcinoma

“…Inhibition of angiogenesis would include: inhibition of angiogenic growth factor production, increased production of angiogenic inhibitors or inhibition of receptors' activity and signaling of blood vessels [20,21,22].…”

Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

“…Examples of the latter are tumor growth and cardiovascular diseases such as atherosclerosis, chronic inflammation, diabetic retinopathy, psoriasis, endometriosis, and rheumatoid arthritis [4,5]. The mechanism of angiogenesis has been recognized as a promising therapeutic target that has to be enhanced or inhibited, depending on the pathology [1,6,7]. Consequently, a better understanding of the process of angiogenesis will help the development of pro- and antiangiogenic therapies.…”

Tumour and dendrimers: a review on drug delivery aspects

“…However, 'the genesis of blood vessels occurring elsewhere in the body is not necessarily abnormal'. Such eruptions occur as a result of genetic aberrations from pre-existing vessels or in a specialized microenvironment from endothelial cell progenitors of bone marrow (Jain et al 1987;Haroon et al 1999;Carmeliet & Jain 2000;Ribbati et al 2001;Peppas & Blanchette 2004;Gjini 2005). Upon undergoing change in the organizational pattern of a gene, the normal cell cycle is disrupted.…”

“…This prevents significant side effects as compared with other strategies. However, it is a difficult concept due to variation in temporal and spatial expression of various growth factors (Ribbati et al 2001;Fainaro et al 2004).…”