Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

Spiegelaere, Ward De; Casteleyn, Christophe; Broeck, Wim Van Den; Plendl, Johanna; Bahramsoltani, Mahtab; Simoens, Paul; Djonov, Valentin; Cornillie, Pieter

doi:10.1159/000338278

Cited by 172 publications

(130 citation statements)

References 208 publications

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“…Notably, angiogenesis has been found to closely correlate with prognosis and hematogenous metastasis of gastric cancer (8). A balance between pro-angiogenic and anti-angiogenic factors in the local environment is important for the development of angiogenesis (5)(6)(7)(9)(10)(11). Numerous pro-angiogenic factors, including factors that act directly and indirectly, are involved in the complex regulation of angiogenesis (5)(6)(7)9,12,13).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

Shi

Wei

2015

Oncology Letters

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Section: Introductionmentioning

confidence: 99%

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

Shi

Wei

2015

Oncology Letters

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“…1). On the contrary, in other specific situations and tissues or in diverse pathological conditions, sprouting angiogenesis (which includes distinct phases such as vessel dilatation, vascular sprout formation and fusion with another sprout or blood vessel) entails the development of new blood vessels directly from existing blood vessels [35] (fig. 1).…”

Section: Angiogenesis Versus Vasculogenesismentioning

confidence: 99%

“…Thus, the angiogenic mechanism does not depend on the incorporation of cells that are not already present in blood vessels. Moreover, although the first observations were reported in 1950 by Short [36], intussusceptive angiogenesis is also accepted as an alternative process for both vascular growth and remodeling [35]. A typical characteristic of intussusceptive angiogenesis, also called splitting or nonsprouting angiogenesis, is the formation of intraluminal pillars by invagination of the capillary walls into the vascular lumen.…”

Section: Angiogenesis Versus Vasculogenesismentioning

confidence: 99%

“…1). Two other angiogenic processes termed vascular mimicry and blood vessel cooption appear restricted to pathological situations such as tumor growth [35]. On the following pages, we identify and discuss the different populations of endothelial precursors and supportive cells that varied in terms of phenotype and purity with an emphasis on their contributions to blood vessel growth and repair.…”

Section: Angiogenesis Versus Vasculogenesismentioning

confidence: 99%

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The Challenges for Cardiac Vascular Precursor Cell Therapy: Lessons from a Very Elusive Precursor

2013

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There is compelling evidence that cardiovascular disorders arise and/or progress due mainly to endothelial dysfunction. Novel therapeutic strategies aim to generate new myocardial tissue using cells with regenerative potential, either alone or in combination with biomaterials, cytokines and advanced monitoring devices. Among the human adult progenitor cells used in such methods, those historically termed ‘endothelial progenitor cells' show promise for vascular growth and repair. Asahara et al. [Science 1997;275:964-967] initially described putative endothelial cell precursors in 1997. Subsequently, distinct cell populations termed endothelial colony-forming units-Hill, circulating angiogenic cells and endothelial colony-forming cells were identified that varied in terms of phenotype, vascular homeostasis contribution and purity. Notably, most of these cells are not genuine vascular precursor cells belonging to the endothelial lineage. This review provides a broad overview of the main properties of the endothelium, focusing on the basis governing its growth and repair. We discuss efforts to identify true vascular precursors, a matter of debate for the past 15 years, as well as recent methodological advances in identifying new hierarchies of more homogeneous, clonogenic and proliferative vascular endothelial-lineage precursors. Consideration of these issues provides insights that may help develop more effective therapies against human diseases that involve vascular deficits.

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“…Consequently, the mechanism of intussusceptive angiogenesis is often overlooked in angiogenesis research [27]. Intussusception is an alternative to the sprouting mode of angiogenesis.…”

mentioning

confidence: 99%

Role of Notch, SDF-1 and Mononuclear Cells Recruitment in Angiogenesis

Dimova¹,

Djonov²

2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

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Intussusceptive angiogenesis (IA) known also as splitting angiogenesis is a recently described mechanism of vascular growth alternative to sprouting. It plays an essential role in the vascular remodeling and adaptation of vessels during normal and pathological angiogenesis. It is an "escape" mechanism during and after irradiation and anti-VEGF therapy, both inducing angiogenic switch from sprouting to IA by formation of multiple transluminal tissue pillars. Our recently published data revealed the significant induction of IA after inhibition of Notch signaling associated with an increased capillary density by more than 50%. The induced IA was accompanied by detachment of pericytes from basement membrane, increased vessel permeability and recruitment of mononuclear cells toward the pillars; the process was dramatically enhanced after injection of bone marrowderived mononuclear cells. The extravasation of mononuclear cells with eventual bone marrow origin was associated with upregulation of chemotaxis factors SDF-1 and CXCR4. In addition, SDF-1 expression was upregulated in the endothelium of liver sinusoids in Notch1 knockout mouse, together with vascular remodeling by intussusception. In this chapter, we discuss this important mechanism of angiogenesis, as well as the role of Notch signaling, SDF-1 signaling and mononuclear cells in the complex process of angiogenesis.

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Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

Cited by 172 publications

References 208 publications

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

The Challenges for Cardiac Vascular Precursor Cell Therapy: Lessons from a Very Elusive Precursor

Role of Notch, SDF-1 and Mononuclear Cells Recruitment in Angiogenesis

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