2009
DOI: 10.1016/j.bone.2009.01.367
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Abstract: Joint loading is a recently developed loading modality that induces anabolic responses by lateral loads applied to a synovial joint such as an elbow and a knee. The present study extended this loading modality to an ankle and addressed a question: does ankle loading promote bone formation in the tibia? If so, what signaling pathways are involved in the anabolic responses? Using C57BL/6 female mice as a model system, lateral loads of 0.5 N were applied to the ankle at 5 Hz for 3 min/day for 3 consecutive days a… Show more

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Cited by 46 publications
(47 citation statements)
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References 48 publications
(53 reference statements)
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“…The load-driven pressure may generate fluid flow in a lacuna canalicular network in bone cortex. The pressure also activates bone metabolism-related genes in femur and tibia [18, 19]. In our previous works, knee loading stimulated bone formation by conducting bone histomorphometry using the cross-sections at 25% (distal femur), 50% (midshaft), and 75% (proximal femur) of the length of the femur from the loading site.…”
Section: Introductionmentioning
confidence: 99%
“…The load-driven pressure may generate fluid flow in a lacuna canalicular network in bone cortex. The pressure also activates bone metabolism-related genes in femur and tibia [18, 19]. In our previous works, knee loading stimulated bone formation by conducting bone histomorphometry using the cross-sections at 25% (distal femur), 50% (midshaft), and 75% (proximal femur) of the length of the femur from the loading site.…”
Section: Introductionmentioning
confidence: 99%
“…Dynamic deformations of the epiphysis cause alterations in fluid pressure in the intramedullary cavity, driving oscillatory fluid flow and molecular transport in the lacunocanalicular network in the bone matrix and in the medullary cavity [4][5][6]. Fluid flow may cause shear stress to osteocytes, stimulating a Wnt-signaling pathway, leading to osteoblast differentiation and the initiation of bone formation [7]. The results from animal studies demonstrate the potential therapeutic effects of knee loading in diseases of low bone mass, in cases of disuse, and in bone fracture treatment.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, for better understanding of the mechanism of mechanical stress-stimulated osteoblastogenesis, a global analysis needs to be performed to examine the cellular response to mechanical stress in a microenvironment similar to that found in vivo. Microarray technology enables the systematic analysis of gene expression, and several studies have utilized it to assess the regulation of in vivo gene expression by mechanical stress in bone tissues (28,50,51). However, most of these studies have utilized long bones wherein bone formation occurs alongside bone resorption or remodeling.…”
Section: Methodsmentioning
confidence: 99%