Jinekoloji Polikliniğine Başvuran Hastalarda İnsan Papillomavirüs Prevalansı ve Genotip Dağılımı

Kaleli, İlknur; Aksoy, Levent; Demir, Melek; Mete, Emin; Önder, Sedef Zeliha; Bir, Ferda; Kaleli̇, Babür

doi:10.5578/mb.67765

Cited by 4 publications

(4 citation statements)

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“…Another study by Yuce et al evaluated the HPV positivity among Turkish women in a hospital-based study and reported that the prevalence of any HPV was 25.7%, while highrisk HPV was positive at 23.0%, and the genotype distribution showed that the most common single type was HPV-16, followed by HPV-31 and HPV-51 [12]. The HPV genotypes 16 and 18 were common in almost all studies in the literature, but the HPV-39 and HPV-56 found in our study were not commonly or frequently reported in other studies [8,9,13]. To our knowledge, only Alacam and Bakir reported that HPV-39 was one of the most common genotypes found in women with cervical dysplasias [10].…”

Section: Discussioncontrasting

confidence: 56%

“…Astudy by Dursun et al evaluated the prevalence of HPV DNA and cervical cytological abnormalities in twelve centers and reported that 25% of 6388 women were HPV positive [8]. Another study by Kaleli et al evaluated HPV positivity in a tertiary healthcare setting in the Aegean region of Turkey and reported a positivity rate of 37.2% [9]. A more recent study by Alacam and Bakir evaluated the HPV prevalence and genotype distribution in Istanbul, Turkey, and reported that 36.3% of 2285 women were positive for HPV [10].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years

Önal¹,

Katırcı²,

Kocaman³

et al. 2022

Med-Science

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Cervical cancer is the fourth most common cancer worldwide. Furthermore, it is the 9thmost common cancer in all ages and the 4thmost common in the 25-49 age group of women in Turkey. Given these significantly high figures, it is a significant public health problem. Therefore, this study aimed to evaluate the epidemiological characteristics of patients screened for Human papillomavirus (HPV) in a tertiary-care setting in Turkey. This is a retrospective chart review of patients admitted for clinical examinations and who underwent cervical cancer screening between 1 January 2017 and 1 March 2022. The data analyses included HPV positivity, genotype distribution, cytology analyses, colposcopy results, pathological diagnoses, and follow-up methods. A total of 529 cases were included, of whom 41.6% were HPV positive. The most frequent HPV types were HPV-16 (16.6%) and HPV-high risk (HR) (12.1%). Cytology analyses revealed atypical squamous cells of undetermined significance (ASC-US) in 17.8% and low-grade squamous intraepithelial lesions (LSIL) in 12.7%. The most common pathological finding was cervicitis in 23.1% (n=122), cervical intraepithelial neoplasia (CIN)-1 in 9.3% (n=49), CIN-3 in 4% (n=21), and CIN-2 in 3.8% (n=20) of patients. HPV-59 (p=0.027) and HPV-HR (p=0.003) genotypes were determined in higher proportions in patients with ≥ASC-US cytology, and HPV-16 was significantly higher among patients with ≥CIN-1 lesions. The HPV positivity rate was 41.6% among women admitted to our tertiary-care university hospital for gynecological assessments. Distribution differences in HPV genotypes, cytology assessments, and pathological diagnoses might reflect the population characteristics in different geographical regions from previous studies. Our results provide current data for HPV surveillance in the Turkish population.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years

Önal¹,

Katırcı²,

Kocaman³

et al. 2022

Med-Science

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“…The most common HPV types in their study were HPV 16, HPV 39, and HPV 51. [18] In the study by Kaleli et al [19] in the Aegean region, HPV positivity was found to be 37.2%. Kaleli et al [19] determined the highest HPV prevalence as HPV 16 with 8.9%, followed by 6, 53, and 52/53/35/58.…”

Section: Table 1: Cervical Lesion Distribution By Hpv Subtypesmentioning

confidence: 94%

“…[18] In the study by Kaleli et al [19] in the Aegean region, HPV positivity was found to be 37.2%. Kaleli et al [19] determined the highest HPV prevalence as HPV 16 with 8.9%, followed by 6, 53, and 52/53/35/58. Yuce et al [20] found that the most common type was HPV 16, followed by HPV 31 and HPV 51.…”

Section: Table 1: Cervical Lesion Distribution By Hpv Subtypesmentioning

confidence: 94%

The relationship between cervical lesions and human papillomavirus subtypes: A retrospective third stage single-center study

Bayramoğlu

2024

Zeynep Kamil Med J

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Objective: Cervical cancer is a preventable disease. Oncogenic HPV subtypes play a very important role in the development of many cancers, especially cervical cancer. In this study, we aimed to investigate the importance of HPV subtypes in cervical lesions.Material and Methods: Two hundred seventeen women who were examined in the gynecological oncology outpatient clinic of the hospital, had a positive HPV test, and underwent colposcopic biopsy were retrospectively analyzed. The clinical and examination information of the patients were obtained from the hospital system and files.Results: Among the HPV subtypes in the patients, HPV subtype 16 was the most common. HPV subtype 16 was found most frequently in H-SIL and L-SIL lesions. In addition, cervical premalignant or malignant lesions were detected in 79 of 217 patients who underwent colposcopic cervical biopsy. Conclusion:Cervical cancer screening methods are one of the few screening methods that have been proven to reduce the mortality and incidence of invasive cancer. The most important risk factor in the etiology of cervical cancer is the HPV virus. As a result, we found that HPV subtype 16 was the most common, and HPV positivity decreased with age.

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The prevalence and distribution of human papillomavirus in 4267 Turkish women with or without cervical lesions: A hospital‐based study

Altay-Kocak

Kazanci

Dogu-Tok

et al. 2022

Journal of Medical Virology

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In the present study, it was aimed to screen the genotypes of human papillomavirus (HPV) retrospectively in women with gynecological symptoms who were admitted to a tertiary care university hospital in Ankara, Turkey. A total of 4267 cervical swab samples of women aged 18–79 years were sent to Medical Virology Laboratory from January 2017 to November 2020. Nucleic acid extraction and amplification of samples were done by an automated system. The test can detect 14 high‐risk HPV (HR‐HPV) types in a single analysis that performs a real‐time polymerase chain reaction, by providing individual results on the highest‐risk genotypes HPV 16 and HPV 18 and pooled results on other high‐risk genotypes (OHR‐HPV) (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68). HPV DNA positivity was detected in 14.2% (605/4267) of the samples. HPV type 16 and type 18 were detected in 2.4% and 0.7% of the samples, respectively. OHR‐HPV types were found in 8.8% of the samples. Of the 1.9% and 0.4% samples had mixed types with type 16+ OHR‐HPV and type 18+ OHR‐HPV, respectively. The results of this study presented the rates of HR‐HPV genotypes of a university hospital in Ankara, over a 4‐year period. It was observed that the positivity rate of type 18 is decreasing and some OHR‐HPV types are increasing. HPV vaccination is not in the national immunization program in Turkey yet, however, HPV vaccines are available and the vaccination rates for women are increasing.

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Jinekoloji Polikliniğine Başvuran Hastalarda İnsan Papillomavirüs Prevalansı ve Genotip Dağılımı

Cited by 4 publications

References 0 publications

Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years

Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years

The relationship between cervical lesions and human papillomavirus subtypes: A retrospective third stage single-center study

The prevalence and distribution of human papillomavirus in 4267 Turkish women with or without cervical lesions: A hospital‐based study

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