Jaw cysts – Filling or no filling after enucleation? A review

Ettl, Tobias; Gosau, Martin; Sader, Robert; Reichert, Torsten E.

doi:10.1016/j.jcms.2011.07.023

Cited by 92 publications

(85 citation statements)

References 64 publications

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“…Concerning the literature, the careful enucleation of small lesions plus a scrupulous surgical debridement (uncombined with biomaterials filling of the remaining cavity) is the unanimous procedure to ensure a satisfactory bone regeneration (1)(2)(3)(4)(5)(6)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In regard to post-surgical medium and large cavities (> 3 cm), defined by Horowitz's 1989 classification (1)(2)(3)(4)(5)(6)(7), there isn't any consensus on treatment procedure; conversely there're different alternative proposals to the only spontaneous regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have shown, by periodical clinical-radiographic follow-ups, that residual large cavities can undergo to spontaneous regeneration in the totality of cases. Reviewing the literature, there's not evidence to fill cavity with autologous bone grafts or alloplastic materials, which could increase postoperative morbidity and would delay the healing time (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). After the surgery procedure, the fracture is the complication of large lesions due to the size and the excessive bone fragility.…”

Section: Introductionmentioning

confidence: 99%

“…After the enucleation of an expansive benign bone lesion, newly formed bone developed from primary clot organization (which spills from the cavity walls) and progressively fills the residual cavity. Usually an almost complete cavity ossification is radiographically visible since 6 to 12 months; however the time range is related to cyst initial size, number of intact residual walls and to patient's age [young patients heal faster (8,9,12,22,23)]. Concerning large cavities (more than 3 cm in diameter), literature indicates this data about the average percentage reduction (9,12,23):…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions

Bertolai

Catelani

Signorini

et al. 2016

ccmbm

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SummaryBackground. Recent studies have highlighted that MSCs are capable of regenerating large bone defects when used in combination with bone substitutes and increasing allograft osteointegration. We investigated the hypothesis that autologous MSCs may lead to increased bone regeneration and reduced healing time in post-surgical cavities of large maxillary bone lesions. Methods. This study involved 10 patients (TEST GROUP) (6 males and 4 females). All patients had expansive mandibular lesions larger than 3 cm. From the surgical point of view, the 10 patients were treated with MSCs (withdrawal of the iliac crest bone marrow BMMSs) directly into the post-surgical cavity, without the addition of filler. Results. Clinical and radiological data, in the postoperative, were compared to those of patients who did not receive any grafting of MSCs. The 7 patients with mandibular lesions showed a rapid and very good healing with an 85-90% ossification of the major defect at 12 months. Conclusions. Through the use of stem cells a greater ossification of the residual cavity (85-90%) was observed at 12 months after surgical enucleation in contenitive defects.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions

Bertolai

Catelani

Signorini

et al. 2016

ccmbm

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“…In addition to reducing infection and healing disturbance, these materials have been used to accelerate bone regeneration, prevent soft-tissue collapse into the defect, and improve bone strength [3]. Autologous bone has repeatedly been reported to represent the gold standard of bone grafting, and the iliac crest is the most frequently chosen donor site because the iliac spongiosa provides osteoconductive, osteoinductive, and osteogenic properties [4].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Intraosseous Cystic Lesions of the Mandible by Conservative Enucleation and Cavity Filling with Allogenic Freeze-Dried Bone Mixed with Autologous Bone Marrow

Chen¹

2017

Austin J Surg

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Purpose: The aim of this study was to evaluate the outcome of defect filling with allogenic freeze-dried bone mixed with bone marrow following conservative enucleation of large intraosseous cystic lesions of the mandible. Patients and Methods:Forty-two patients with large intraosseous cystic lesions of the mandible were treated by defect filling with allogenic freeze-dried bone combined with bone marrow following conservative cyst enucleation.Results: All patients showed satisfactory healing. Dental rehabilitation including prosthesis and implant provision was successful in 10 (23.8%) patients. The patients were followed for 13-48 (mean, 29.9) months using panoramic radiographic examination. Recurrence was seen in 2 (11.2%) patients with KCOTs. Clinical and panoramic radiographic examination showed no residual or recurrent cyst in the remaining patients. Conclusion:Allogenic freeze-dried bone mixed with autologous bone marrow may be as an alternative, viable filling material for intraosseous cystic lesions of the mandible removed by conservative enucleation.

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“…Cystectomy includes the removal of all inflamed soft tissues and sometimes application of different biomaterials to enhance new bone formation in the defect site [34,35]. Various bone grafts and barrier membranes can be used to achieve optimal healing and regeneration of the cystic cavity.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec®) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation

S¹,

Guarnieri

2013

JOMR

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Objectives: The purpose of the present study was to evaluate the efficacy of adding platelet-rich plasma (PRP) to a new highly purified bovine allograft (Laddec ® ) in the bone regeneration of cystic bony defects augmented following cystectomy. Material and Methods: Study sample included 20 patients undergoing cystectomy in which the bone defect was filled with PRP and Laddec ® . All patients were examined with periapical radiographs before operation and at follow-up. After 3 months, at re-entry surgery for implant placement, bone core was taken for histological and histomorphometric analysis. Results: The postoperative successive radiographs showed a good regeneration of bone in the height of bony defects with application of PRP to bone graft. By the first postoperative month, about 48% of the defect was filled, which gradually increased in each month and showed about 90% of defect-fill by 6 months. Histological and histomorphometric analysis, showed a significant presence of bone tissue and vessels, with newly formed bone in contact with anorganic bone particles. The mean volume of vital bone was 68 ± 1.6% and the mean percentage of vital bone was 48 ± 2.4%. The mean percentage of inorganic particles in tissues was 20 ± 1.2% of the total volume. All the samples analyzed did not evidence the presence of inflammatory cells. Conclusions:The results of this study showed how the use of Laddec ® in association with platelet-rich plasma allows bone regeneration and has a potential for routine clinical use for regeneration of cystic bony defects.

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Jaw cysts – Filling or no filling after enucleation? A review

Cited by 92 publications

References 64 publications

Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions

Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions

Treatment of Intraosseous Cystic Lesions of the Mandible by Conservative Enucleation and Cavity Filling with Allogenic Freeze-Dried Bone Mixed with Autologous Bone Marrow

Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec®) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation

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