JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Wang, Shouyu; Liang, Ke; Hu, Qingsong; Li, Ping; Song, Jian; Yang, Yuedong; Yao, Jun; Mangala, Lingegowda S.; Li, Chunlai; Yang, Wenhao; Park, Peter K.; Hawke, David H.; Zhou, Jianwei; Zhou, Yan; Xia, Weiya; Hung, Mien‐Chie; Marks, Jeffrey R.; Gallick, Gary E.; López-Berestein, Gabriel; Flores, Elsa R.; Sood, Anil K.; Huang, Suyun; Yu, Dihua; Yang, Liuqing; Lin, Chunru

doi:10.1172/jci91553

Cited by 180 publications

(141 citation statements)

References 48 publications

(53 reference statements)

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“…Knockdown of Lnc‐BM facilitates FasL‐induced apoptosis via inhibition of ICAM1. This data suggests that lncRNAs also play important roles in promoting nonangiogenic tumor growth and metastasis …”

Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 87%

“…The upregulation of CASC15 in metastatic melanoma is correlated with the frequent copy number gains at the CASC15 locus, and is associated with progression to brain metastasis. Lnc‐BM is the most recently discovered long noncoding RNA involved in breast cancer brain metastasis. To colonize the brain, metastatic cells have to cross densely packed blood vessels that constitute the blood‐brain barrier.…”

Section: Lncrnas As Novel Players In Cancer Metastasismentioning

confidence: 99%

“…The lungs, liver, and brain, which are vessel‐rich organs, have been described as common sites for hosting nonangiogenic tumors . Lnc‐BM‐mediated breast cancer brain metastasis promotes cancer cell adherence and stretching on vascular capillaries . Knockdown of Lnc‐BM facilitates FasL‐induced apoptosis via inhibition of ICAM1.…”

Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 99%

“…64 Lnc-BM-mediated breast cancer brain metastasis promotes cancer cell adherence and stretching on vascular capillaries. 37 Knockdown of Lnc-BM facilitates FasL-induced apoptosis via inhibition of ICAM1. This data suggests that lncRNAs also play important roles in promoting nonangiogenic tumor growth and metastasis.…”

Section: Lncrnas In Angiogenesismentioning

confidence: 99%

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Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Egranov

Yang

et al. 2019

Genes Chromosomes & Cancer

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Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ‐specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.

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Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 87%

Section: Lncrnas As Novel Players In Cancer Metastasismentioning

confidence: 99%

Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 99%

Section: Lncrnas In Angiogenesismentioning

confidence: 99%

See 2 more Smart Citations

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Egranov

Yang

et al. 2019

Genes Chromosomes & Cancer

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“…Recently, some dysregulated lncRNAs were identified to be diagnostic biomarkers or therapeutic targets. A growing body of evidence has indicated that lncRNAs play crucial roles in tumour growth and metastasis including colon cancer . Thus, increasing dysregulated lncRNAs have been demonstrated to be associated with prognosis of cancer patients and even predict clinical responses to cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis and validation of dysregulated long non‐coding RNAs in colon cancer

Zhang

Bian

Zhu

et al. 2020

J Cellular Molecular Medi

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It is an increasing evidence that long non‐coding RNAs (lncRNAs) are involved in tumour initiation and progression. Here, we analysed RNA‐sequencing data from the Cancer Genome Atlas (TCGA) datasets. Totally, 1176lncRNAs, 245miRNAs and 2081mRNAs were identified to be differentially expressed (DE) in colon cancer tissues compared with normal tissues. CASC21, a novel lncRNA located in 8q24.21 locus, was significantly overexpressed in 30 colon cancer tissues compared with matched normal tissues by qRT‐PCR assay. CASC21 tended to higher expression as the increase of the tumour‐node‐metastasis (TNM) classification. Functionally, CASC21 promoted cell proliferation by regulating cell cycle and enhanced tumour metastasis by epithelial‐mesenchymal transition (EMT) in colon cancer. Mechanism study indicated that CASC21 might be involved in activating WNT/β‐catenin pathway in colon cancer. In addition, we also built a competing endogenous RNA (ceRNNA) network by bioinformatic analysis using TCGA datasets. Together, our results not only provide novel lncRNAs as potential candidates for further study but also prove that CASC21 is an oncogenic regulator through activating WNT/β‐catenin signalling in colon cancer.

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Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR‐7

et al. 2020

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Breast cancer is the second leading cause of cancer‐related deaths in women. The long noncoding RNA LINC00115 has been reported to be involved in the poor outcome of patients with breast cancer, but the biological function and underlying mechanism remain unclear. Here, we report that LINC00115 expression is increased in triple‐negative breast cancer tissue compared with matched normal tissue, and LINC00115 knockdown suppresses breast cancer cell migration and invasion. Furthermore, we show that LINC00115 directly targets miR‐7 and inhibits its expression. LINC00115 also reduces the expression of KLF4, which is a direct target of miR‐7 and is involved in breast cancer metastasis. Together, our findings suggest that LINC00115 promotes breast cancer metastasis through modulating the expression of miR‐7 and KLF4.

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JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Cited by 180 publications

References 48 publications

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Integrative analysis and validation of dysregulated long non‐coding RNAs in colon cancer

Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR‐7

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