Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Li, Yajuan; Egranov, Sergey D.; Yang, Liuqing; Lin, Chunru

doi:10.1002/gcc.22691

Cited by 82 publications

(61 citation statements)

References 91 publications

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“…5,6 Moreover, many lncRNAs are identified to be closely associated with initiation and progression of various cancers. 7,8 A number of lncRNAs have emerged as crucial regulators in the physiopathology of LSCC, specifically, as potential diagnostic biomarkers or therapeutic targets for this disease. 9,10 CDKN2B antisense RNA 1 (CDKN2B-AS1 also named ANRIL), a 3.8-kb lncRNA, was reported to be upregulated in tumor tissues and function as an oncogenic lncRNA in multiple cancers, such as hepatocellular carcinoma, 11 non-small cell lung cancer, 12 ovarian cancer, 13 cervical cancer, 14 pancreatic cancer, 15 and bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

<p>Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway</p>

Cui¹,

Yu²,

Shang³

et al. 2019

OTT

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Background: CDKN2B antisense RNA 1 (CDKN2B-AS1), a long noncoding RNA, was reported to play crucial roles in the progression of multiple cancers. However, the functional roles and regulatory mechanism of CDKN2B-AS1 in human laryngeal squamous cell cancer (LSCC) remain unclear. The goals of this study were to investigate biological roles and underlying mechanisms of CDKN2B-AS1 in LSCC. Methods: The expressions of CDKN2B-AS1, miR-497 and cyclin-dependent kinase 6 (CDK6) were detected in LSCC tissues and cell lines by real-time quantitative PCR (qRT-PCR). The effects of CDKN2B-AS1 on LSCC cell proliferation, apoptosis, migration and invasion were examined by corresponding experiments. Bioinformatics analysis and luciferase activity assay were applied to analyze the interaction between CDKN2B-AS1 and miR-497. Results: The expression of CDKN2B-AS1 was significantly higher in LSCC tissues than in adjacent normal tissues. Higher CDKN2B-AS1 was closely associated with lymph node metastasis and advanced clinical stage. Moreover, CDKN2B-AS1 knockdown by siRNA significantly inhibited the proliferation, induced cell apoptosis, and suppressed migration and invasion in LSCC cells. Mechanically, CDKN2B functions as an oncogenic lncRNA in LSCC via regulating miR-497/CDK6 axis. Conclusion: The observations in this study identify CDKN2B-AS1 an oncogenic role in the tumorigenesis of LSCC by regulating miR-497/CDK6 axis and indicate that it may serve as a potential target for LSCC treatment.

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Section: Introductionmentioning

confidence: 99%

<p>Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway</p>

Cui¹,

Yu²,

Shang³

et al. 2019

OTT

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“…Previous studies have indicated that long non-coding RNAs (lncRNAs) are involved in different biological processes of cells, particularly in gene expression via the regulation of transcription and post-transcriptional processing as well as chromatin modification. They can also potentially contribute to tumor progression and metastasis in different types of tissue (10)(11)(12). p53 mutations occur in 40-50% of sporadic cases of CRC, resulting in direct deactivation of the affected gene (13).…”

Section: Association Of Lncrna-p53 Regulatory Network (Lincrna-p21 Lmentioning

confidence: 99%

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

et al. 2020

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Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. The detection of CRC has proved problematic when in the early stages of disease. In addition, identifying suitable biomarkers for the detection of CRC progress in patients remains one of the most significant challenges. Long non-coding RNAs have been demonstrated to contribute to the promotion of CRC. The aim of the present study was to investigate the clinical and biological significance of long intergenic non-coding (linc)RNA-p21, lincRNA-regulator of reprogramming (ROR) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the colon tumor and polyp tissue, and the association that these have with the expression of p53 at the mRNA level. Neoplastic and paired adjacent normal tissue samples were obtained from 72 patients (46 polyps and 26 tumors). Reverse transcription-quantitative PCR was performed to determine the relative fold changes in the expression of lincRNA-p21, lincRNA-RoR, MALAT1 and p53 in the samples. A significant association was observed between the levels of MALAT1 and p53 in neoplasm tissues (R=0.073; P<0.05). The relative expression of the MALAT1 gene revealed a statistically significant difference between the different polyp types and number of polyps (P=0.0028 and 0.022, respectively). Adjuvant therapy in patients with tumors revealed an association between the levels of lincRNA-ROR and lincRNA-p21 expression (P=0.015 and 0.038, respectively). MALAT1 may be selected as an early detection biomarker for CRC. Furthermore, lincRNA-ROR and lincRNA-p21 may serve as prognostic and therapeutic biomarkers in patients with CRC.

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“…Long non-coding RNAs (lncRNAs) are transcripts with greater than 200 nucleotides but lack protein coding capacity (Sanchez Calle et al, 2018). lncRNAs are closely associated with various key biological processes, such as cell cycle regulation, immune response, and embryonic stem cell pluripotency Agirre et al, 2019;Li et al, 2019b). More importantly, lncRNAs play an important role in understanding pathogenesis of various diseases, especially tumors (Chen et al, 2016a;Fu et al, 2017;Jiang et al, 2018;He et al, 2018a;Dallner et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Studies reported that lncRNAs can activate post-transcriptional gene regulation, splicing, and translation by binding to proteins (Zhang et al,. 2018c;Li et al, 2019a) Therefore, identifying possible lncRNA-protein interactions (LPIs) is essential for unraveling lncRNA-related activities (Qian et al, 2018;Zhang et al, 2018c;Zhao et al, 2018c). Wet experiments validated parts of LPIs, but experimental methods remain costly and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Probing lncRNA–Protein Interactions: Data Repositories, Models, and Algorithms

Peng

Liu

Yang³

et al. 2020

Front. Genet.

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Identifying lncRNA-protein interactions (LPIs) is vital to understanding various key biological processes. Wet experiments found a few LPIs, but experimental methods are costly and time-consuming. Therefore, computational methods are increasingly exploited to capture LPI candidates. We introduced relevant data repositories, focused on two types of LPI prediction models: network-based methods and machine learning-based methods. Machine learning-based methods contain matrix factorization-based techniques and ensemble learning-based techniques. To detect the performance of computational methods, we compared parts of LPI prediction models on Leave-One-Out cross-validation (LOOCV) and fivefold cross-validation. The results show that SFPEL-LPI obtained the best performance of AUC. Although computational models have efficiently unraveled some LPI candidates, there are many limitations involved. We discussed future directions to further boost LPI predictive performance.Keywords: lncRNA-protein interaction, computational method, network-based method, machine learning-based method, data repositories

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Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Cited by 82 publications

References 91 publications

<p>Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway</p>

<p>Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway</p>

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

Probing lncRNA–Protein Interactions: Data Repositories, Models, and Algorithms

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