Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Herold, Mitchell; Nielson, Colton; Longo, María Isabel

doi:10.1111/dth.12803

Cited by 14 publications

(8 citation statements)

References 15 publications

(17 reference statements)

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“…Reports of two cases by McDonald et al 7 . and one case by Burton and Sawchuk, 8 also indicated safe and effective treatment of the same entity with isotretinoin, Herold et al 9 . reported two cases of recalcitrant warts in patients with renal impairment following solid organ transplants, one of whom was on renal dialysis, who had successful treatment with isotretinoin 20 mg daily in combination with immunotherapy for Candida .…”

Section: Resultsmentioning

confidence: 96%

How safe and effective is prescribing oral isotretinoin to treat acne in patients on renal dialysis? A systematic review

Gan

Therianou

2021

Clin Experimental Derm

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Background. Patients on renal dialysis often develop severe acne. In spite of this, the literature remains scarce about the use of isotretinoin for the treatment of acne in this group of patients, and many clinicians remain apprehensive and hesitant to use it. Aim. To systematically review the literature surrounding the safety and efficacy of isotretinoin for the treatment of acne in patients on renal dialysis. Methods. Four electronic databases (MEDLINE, Embase, CINAHL, Emcare) were systematically searched in March 2021. The search strategy incorporated the terms 'isotretinoin', 'renal', 'kidney', 'dialysis' and 'acne', along with terms closely related to these. Studies were considered eligible if they reported the use of isotretinoin for treatment of acne in patients with renal impairment or on renal dialysis, and if they had relevant implications to this topic. Results. The search resulted in a total of 63 results. Using the PRISMA approach, 11 articles were deemed relevant to this review: 1 randomized single-blinded placebo-controlled trial, 2 case series, 2 retrospective studies and 6 case reports. Hence the level of evidence was mostly low (Grading of Recommendations, Assessment, Development and Evaluations level 3). Conclusion. This review of the literature suggests that low-dose isotretinoin (10-20 mg) can safely and successfully be used to treat severe acne in patients on renal dialysis, leading to a significant improvement in their quality of life. As the current literature on this topic is scarce, more studies would be beneficial to further establish the safe use of isotretinoin in patients on renal dialysis.

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Section: Resultsmentioning

confidence: 96%

How safe and effective is prescribing oral isotretinoin to treat acne in patients on renal dialysis? A systematic review

Gan

Therianou

2021

Clin Experimental Derm

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“…8 In both conditions, viral warts precede the onset of carcinoma. 9 Another relevant factor is the higher prevalence of HPV in samples of squamous cell carcinomas (78%) when compared to basal cell carcinomas (36%) and even normal skin (32%). 8 Nevertheless, the mere evidence of a viral infection is not enough to incur a malignant transformation, because most patients infected with HPV do not develop cancer.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Guerra

Simões

Vieira³

et al. 2021

SPDV

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Carcinoma cuniculatum is a rare variant of low-grade and well-differentiated squamous cell carcinoma. It is a locally invasive tumor, although it has low metastatic potential. It was originally described in the plantar region but may exceptionally appear in other locations. It predominates in middle-aged men and presents clinically as an exophytic, solitary, painful tumor, with insidious growth. Histologically, this tumor simulates a variety of benign dermatoses and may require several biopsies for the correct diagnosis. It is often misdiagnosed as a viral wart, due to the clinical similarity and the indolent course. The treatment of choice is surgical excision due to the high risk of recurrence and locally aggressive behavior. Amputation can be performed in cases of deep tissue invasion. We present a case of carcinoma cuniculatum in which the late diagnosis favored the invasion of the underlying bone, resulting in amputation of the affected finger.

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“…A combination of IFN-alpha-2a (3 million units, three times a week for 2 months) and oral isotretinoin (0.5 mg kg -1 day -1 for 3 months) was found to be highly effective in recalcitrant warts (Yildirim, Inaloz, Baysal, Kesici, & Candir, 2004). Herold, Nielson, and Longo (2019) observed that isotretinoin 20 mg/day in combination with candida immunotherapy 0.2 cc/2 weeks showed a drastic improvement within few weeks in two adult patients with recalcitrant warts.…”

Section: Wartsmentioning

confidence: 99%

“…Herold, Nielson, and Longo () observed that isotretinoin 20 mg/day in combination with candida immunotherapy 0.2 cc/2 weeks showed a drastic improvement within few weeks in two adult patients with recalcitrant warts.…”

Section: Indications Of Low‐dose Isotretinoin In Dermatologymentioning

confidence: 99%

Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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Isotretinoin is a first‐generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti‐inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date‐unlimited PubMed search, from inception till December 2019, using the following search terms: “low‐dose isotretinoin” and “dermatology,” “isotretinoin and safety,” “isotretinoin, off‐label uses,” “isotretinoin and male fertility,” “isotretinoin, iPLEDGE system,” aiming to deliver a therapeutic update relevant to clinical practice. All English‐language articles were considered with no limitation based on the articles' type. Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.

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Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Cited by 14 publications

References 15 publications

How safe and effective is prescribing oral isotretinoin to treat acne in patients on renal dialysis? A systematic review

How safe and effective is prescribing oral isotretinoin to treat acne in patients on renal dialysis? A systematic review

Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Low dose of isotretinoin: A comprehensive review

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