Isorhamnetin3-(2,6-dirhamnosylgalactoside)-7-rhamnoside and 3-(6-rhamnosylgalactoside)-7-rhamnoside from Rhazya stricta

Andersen, William K.; Omar, Abdallah A.; Christensen, Søren Brøgger

doi:10.1016/s0031-9422(00)81530-7

Cited by 22 publications

(13 citation statements)

References 13 publications

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“…These alkaloids are found in plants of the Apocynaceae, Rubiaceae and Loganiaceae families (Bruneton, 1995;Verpoorte, 1998). Over 100 alkaloids have been isolated, characterized and identified from R. stricta leaves (Ahmad et al, 1979(Ahmad et al, , 1983Andersen et al, 1987;Atta-ur-Rahman andKhanum, 1985, 1987;, 1987a, 1987bBanerji et al, 1970;Chatterjee et al, 1962;Evans et al, 1968;Habib-ur-Rehman and Atta-ur-Rahman, 1996;Miana et al, 1982;Mukhopadhayay et al, 1981Mukhopadhayay et al, , 1983Schnoes et al, 1962), stems , roots (Ahmad et al, 1970(Ahmad et al, , 1971Atta-ur-Rahman andZaman, 1986a, 1986b;Atta-ur-Rahman et al, 1995Mukhopadhayay et al, 1981;Siddiqui et al, 1966) and legumes (Atta-ur-Rahman and Malik, 1984a, 1984b, as well as from mixtures of aerial parts . Most of them are new chemical compounds, but the pharmacological activities of very few are known (Table 1).…”

Section: Chemical Constituentsmentioning

confidence: 99%

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Gilani

Kikuchi

Shinwari

et al. 2006

Phytotherapy Research

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Rhazya stricta Decne. is an important medicinal species that is rich in alkaloids containing anticancer alkaloids also. This paper reviews phytochemical, pharmacological and ethnobotanical studies of R. stricta. Phytochemical and pharmacological aspects of the species have been thoroughly explored. Over 100 alkaloids have been isolated from R. stricta, but the pharmacological activities are known for only a few of these compounds. Very few ethnobotanical studies of R. stricta have been done, and there is a particular need for such studies in various regions of South Asia and in Middle Eastern countries where the species grows. These ethnobotanical studies should investigate herbal recipes of R. stricta and their use for curing diseases. The genetic diversity, chemotaxonomy and allelopathy of R. stricta have not yet been explored, and these studies are recommended, with the ultimate goal of benefiting local communities in regions where R. stricta grows. This should be achieved by sharing knowledge and through the manufacture of herbal drugs from R. stricta's active chemical constituents, while protecting intellectual property rights and following the World Health Organization's guidelines for safety and efficacy.

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Section: Chemical Constituentsmentioning

confidence: 99%

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Gilani

Kikuchi

Shinwari

et al. 2006

Phytotherapy Research

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“…Leaves are used in snakebite Acid potassium oxalate, isoorientin, isovitexin and swertisin (Mizokami et al, 2008;Chopra, 1956;Baquar, 1989;Qureshi et al, 2009) (Baquar, 1989, Treimer andKaneko and Namba, 1967;Andersen et al, 1987;Kaneko and Namba, 1967;Panhwar and Abro, 2007) 24 (Baquar, 1989;Chopra et al, 1956;Alfawaz, 2006) 26 Salvadora persica Salvadoraceae It is found abundantly all over the Pakistan Leaves and flowers are used for snake biting Carbohydrates, alkaloid (salvadorine), steroids, terpenoids, saponins, flavonoids (quercetin and kaempferol) (Almas, 2001;Kamil et.al., 1999, a, b, c;et al, 2000a, b) (Nasir , 1978;Baquar, 1989;Smith and Meeuse, 1966;Borg-Karlson et al, 1994;Chen and Meeuse, 1971;Shinwari and Khan, 2000) (Baquar, 1989; 30…”

Section: Oxalis Corniculata Linn Oxalidaceaementioning

confidence: 99%

Enlisting the scientifically unnoticed medicinal plants of Pakistan as a source of novel therapeutic agents showing anti-venom activity

Asad¹

2011

Afr. J. Pharm. Pharmacol.

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Snake bite envenoming is a global occupational hazard and most of the people of the world trust in traditional medicine for snake poisoning. The present review elaborates scientifically un-investigated/ ignored medicinal plants of Pakistan showing chemical constituents of natural origin with possible mechanisms showing anti-venom activity. This review enlists 35 plants with their families, distribution in Pakistan, parts used traditionally for snake bite treatment and various active principles present in them. Compositae is the most excessive family, with 3 species, followed by Amaranthaceae, Apocynaceae, Asclepiadaceae, Caesalpinaceae, Labiatae, Pinaceae, Polygonaceae and Verbinaceae having 2 species of medicinal plants. While, one plant species belongs to each, Aizoaceae, Araceae, Boraginaceae, Chenopodiaceae, Cucurbitaceae, Euphorbiaceae, Flacourtiaceae, Gentianaceae, Malvaceae, Menispermaceae, Mimosaceae, Oxalidaceae, Papilionaceae, Plantaginaceae, Salvadoraceae and Solanaceae.As an antidote to snake poisoning, the traditional use of leaves (35%) is higher than roots (25%), whole plant (21%), flower (7%), wood (5%), fruit (5%) and milky juice (2%). Among life forms of plants, herbs (55%) are more excessively used as snake bite remedy than shrubs (31%) and trees (14%). This article may help the researchers to bring novelty in the field of natural products for the treatment of snake bite. However, chemical and pharmacological studies are necessary to confirm the anti-venom claims about these medicinal plants of Pakistan.

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“…A complete set of 1 H-and 13 C-NMR resonance assignments for this compound in DMSO-d 6 is given for reference in the Experimental section (the original data were obtained in CD 3 OD). Compound 3 was first described from Primula veris (Primulaceae), 15) but is present in several other taxa, including Lysimachia fortunei (Primulaceae), 16) Alangium premnifolium (Alangiaceae), 17) and Chenopodium pallidicaule.…”

Section: Deoxyhexose [(Mϩh)ϫ(146ϩ146)]mentioning

confidence: 99%

Flavonol Triglycosides from the Leaves of Hammada scoparia (POMEL) ILJIN.

et al. 2002

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Hammada scoparia (POMEL) ILJIN (ϭArthrophytum scoparium (POMEL) ILJINϭHaloxylon articulatum subsp. scoparium (POMEL) BATT.ϭHaloxylon scoparium POMEL) (Chenopodiaceae) is a small, highly-branched halophytic shrub distributed in south-east Spain, North Africa and parts of Iran, Turkey, Iraq and Syria (Irano-Turanian region).1-3) In Tunisia, it is known locally as 'rimth' 4) and used in traditional medicine to treat eye disorders. 5,6) Aqueous extracts of this plant have also been reported to show anti-cancer, 7) antiplasmodial 7) and larvicidal activity, 8) but relatively little has been published on its phytochemistry. This paper describes the isolation and identification of a new flavonol triglycoside found in the leaves of H. scoparia,Fractionation of an Me 2 CO-H 2 O (1 : 1) extract of leaves of H. scoparia by column chromatography, preparative paper chromatography and semi-preparative HPLC yielded compounds 1-3 as yellow powders. Each of these afforded isorhamnetin (3,5,7,4Ј-tetrahydroxy-3Ј-methoxyflavone) and sugars (1, galactose, rhamnose and xylose; 2, apiose, galactose and rhamnose; 3, galactose and rhamnose) on acid hydrolysis (2 M HCl). The UV spectra of 1-3 recorded in MeOH were similar to those of isorhamnetin 3-O-glycosides, 9) with distinctive maxima at 254 and 354 nm. Use of UV shift reagents 9,10) confirmed that the hydroxyl groups at C-5, C-7 and C-4Ј were free and that the hydroxyl group at C-3 was blocked. , respectively. These preliminary data indicated that compounds 1-3 were isorhamnetin 3-O-triglycosides.The 1 H-NMR spectrum of 1 in DMSO-d 6 contained distinctive resonances for one methoxy group and three anomeric protons. Additional glycosidic and aromatic proton resonances were also observed ( Table 1). The chemical shift and coupling constant data for the aromatic and methoxy protons together with their corresponding 13 C-NMR chemical shifts obtained by heteronuclear single quantum coherence spectroscopy (HSQC) confirmed the identity of the aglycone as isorhamnetin ( Table 1). The 1 H and 13 C resonances of each sugar residue were assigned from double quantum filtered correlation spectroscopy (DQF-COSY), total correlation spectroscopy (TOCSY), HSQC and heteronuclear multiple bond correlation (HMBC) data using the anomeric proton resonances at d 5. 40 (d, Jϭ7.7 Hz), 4.44 (d, Jϭ1.3 Hz) and 4.24 (d, Jϭ7.4 Hz) as starting points (Table 1). These data allowed the glycosidic units to be identified as b-galactopyranose, a-rhamnopyranose and b-xylopyranose, respectively.11) The interglycosidic linkages and the site of attachment between the glycoside and the aglycone were determined from HMBC data and rotating frame Overhauser enhancement (ROE) connectivities detected in 1D XSROESY experiments. 12) A 3 J ( 1 H, 13 C) long-range connectivity (HMBC) between the anomeric proton resonance of b-Gal (d 5.40) and C-3 (d 133.0) of the aglycone confirmed the identity of the primary sugar as b-Gal and the site of attachment of the triglycoside as C-3. This was also suggested by the ROE connectivity det...

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Isorhamnetin3-(2,6-dirhamnosylgalactoside)-7-rhamnoside and 3-(6-rhamnosylgalactoside)-7-rhamnoside from Rhazya stricta

Cited by 22 publications

References 13 publications

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Enlisting the scientifically unnoticed medicinal plants of Pakistan as a source of novel therapeutic agents showing anti-venom activity

Flavonol Triglycosides from the Leaves of Hammada scoparia (POMEL) ILJIN.

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