Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla

Vinh, Le Ba; Jang, Hyun‐Jae; Phong, Nguyen Viet; Cho, Kyoungwon; Park, Sung Sun; Kang, Jong Seong; Kim, Young Ho; Yang, Seo Young

doi:10.1016/j.bmcl.2019.02.022

Cited by 22 publications

(22 citation statements)

References 33 publications

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“…By studying how anti-inflammatory compounds inhibit the expression of inflammatory mediators such as IL-12 p40, IL-6, and TNF-α, therapeutic targets for anti-inflammatory agents can be identified for health promotion and disease prevention [ 6 , 18 ]. In an effort to discover new anti-inflammatory agents from medicinal plants, we extracted the roots of P. tenuifolia three times with MeOH.…”

Section: Resultsmentioning

confidence: 99%

“…Inflammatory cells produce cytokines, including interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α. IL-12 p40, IL-6, and TNF-α play important roles in the inflammatory response, as well as cell apoptosis and transformation [ 1 ]. Many studies have focused on the inhibition of pro-inflammatory cytokines in an effort to decrease inflammation-related diseases [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Vinh

Heo

Phong

et al. 2020

Plants

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The roots of Polygala tenuifolia Wild (Polygalaceae), which is among the most important components of traditional Chinese herbal medicine, have been widely used for over 1000 years to treat a variety of diseases. In the current investigation of secondary metabolites with anti-inflammatory properties from Korean medicinal plants, a phytochemical constituent study led to the isolation of 15 compounds (1–15) from the roots of P. tenuifolia via a combination of chromatographic methods. Their structures were determined by means of spectroscopic data such as nuclear magnetic resonance (NMR), 1D- and 2D-NMR, and liquid chromatography-mass spectrometry (LC-MS). As the obtained results, the isolated compounds were divided into two groups—phenolic glycosides (1–9) and triterpenoid saponins (10–15). The anti-inflammatory effects of crude extracts, fractions, and isolated compounds were investigated on the production of the pro-inflammatory cytokines interleukin (IL)-12 p40, IL-6, and tumour necrosis factor-α in lipopolysaccharide-stimulated bone marrow-derived dendritic cells. The IC50 values, ranging from 0.08 ± 0.01 to 21.05 ± 0.40 μM, indicated potent inhibitory effects of the isolated compounds on the production of all three pro-inflammatory cytokines. In particular, compounds 3–12, 14, and 15 showed promising anti-inflammatory activity. These results suggest that phenolic and triterpenoid saponins from P. tenuifolia may be excellent anti-inflammatory agents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Vinh

Heo

Phong

et al. 2020

Plants

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“…According to our previous research and reported literature, SHL contains many saponins, which are considered to be bioactive compounds with analgesic and anti-inflammatory activities [2,3]. Besides, flavonoids and chlorogenic acid derivatives are essential for the treatment of rheumatic disease and osteoporosis [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Decne. (Lardizabalaceae) is a native shrub that grows on the southern coast of South Korea [1,2]. Stauntonia hexaphylla leaves (SHL) have been used as medicine and functional food to treat diabetes, rheumatic arthralgia, and menstrual pain [3].…”

Section: Introductionmentioning

confidence: 99%

“…Stauntonia hexaphylla leaves (SHL) have been used as medicine and functional food to treat diabetes, rheumatic arthralgia, and menstrual pain [3]. At the same time, according to modern pharmacological research, SHL also has many biological activities such as antioxidant, anti-inflammatory, and anti-osteoporosis properties [2][3][4]. Owing to its biological activities, many pharmaceutical companies in Korea have developed drugs and functional foods to treat prostate diseases, osteoporosis, and rheumatic diseases using SHL.…”

Section: Introductionmentioning

confidence: 99%

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Discrimination and quality evaluation of fifteen components in Stauntonia hexaphylla leaves from different harvest time by HPLC–PDA–ESI–MS/MS and ELSD coupled with multivariate statistical analysis and anti-inflammatory activity evaluation

et al. 2020

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The leaves of Stauntonia hexaphylla (SHL) are a very popular herbal medicine in Korea because it can be used to treat rheumatic osteoporosis and other diseases. However, owing to the inconsistency in harvesting time and growth years, their quality is uneven, which indirectly negatively affects the safety of this medication. Therefore, the difference of constituents in SHL harvested at different seasons and years were analyzed by high-performance liquid chromatography coupled to photodiode-array and electrospray ionization mass spectrometry detectors (HPLC–PDA–ESI/MS). A total of 15 components were tentatively characterized in samples of SHL, including 5 compounds reported for the first time in this plant. Moreover, the relative content of these constitutions was simultaneously determined by HPLC coupled with evaporative light scattering detection (ELSD). Hierarchical clustering analysis (HCA) and principal component analysis (PCA) revealed that the quality has a certain extent difference in different harvest times, the best harvest time was 3 years old growing in autumn. The same harvest time was also suggested based on the anti-inflammatory evaluation.

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Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum

et al. 2020

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Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla

Cited by 22 publications

References 33 publications

Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Discrimination and quality evaluation of fifteen components in Stauntonia hexaphylla leaves from different harvest time by HPLC–PDA–ESI–MS/MS and ELSD coupled with multivariate statistical analysis and anti-inflammatory activity evaluation

Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum

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