Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum

Vinh, Le Ba; Phong, Nguyen Viet; Ali, İrshad; Gao, Dan; Koh, Young Sang; Anh, Hoang Le Tuan; Anh, Do Thi Van; Yang, Seo Young; Kim, Young Ho

doi:10.1007/s00044-020-02613-5

Cited by 16 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 Furthermore, research on mangroves from various countries also proves that A. corniculatum has the potential as a source of anti-inflammatory, antiplasmodial, and antimicrobial compounds for human pathogens including M. tuberculosis. 18,20,22,23 Various compounds have been reported from mangrove A. corniculatum such as sakurasosaponin methyl ester, which has anticancer activity. Compounds embelin have also been reported as potential anticancer agents.…”

Section: Discussionmentioning

confidence: 99%

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

et al. 2022

View full text Add to dashboard Cite

Objective Mangrove (Aegiceras corniculatum) is an abundant natural marine resource of Indonesia, which can be explored for treating periodontal disease due to its potential as immunoregulatory, antibacterial, and antioxidant properties. Purpose To investigate the active compound from Indonesian mangrove leaf extract (A. corniculatum) (MLE) for developing a herbal-based mouthwash through in silico and in vitro studies. Materials and Methods Phytochemistry and liquid chromatography-high resolution mass spectrometry (LC-HRMS) were done to explore the active compounds in MLE. Chemistry screening and interaction, absorption, distribution, metabolism, and excretion (ADME), molecular docking simulation, and visualization of MLE active compounds as anti-inflammatory, antioxidant, and antibacterial were investigated in silico The inhibition zone of MLE against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Fusobacterium nucleatum (Fn) as periodontopathogenic bacterias was performed by diffusion method. Doxycycline 100 mg was used as a positive control, as a treatment group, there were five groups, namely 0%, 25%, 50%, 75%, and 100% MLE. Results Alkaloid, saponin, flavonoid, triterpenoid, steroid, tannin, and quinone were detected in MLE. A high concentration of (-)epicatechin and coumaric acid (CA) were found in MLE. MLE in 100% concentration has the most effective ability to inhibit Fn, Pg, Aa growth in vitro. (-)-Epicatechin has a higher negative binding affinity than CA that can enhance heat shock protein (HSP)-30, HSP-70, HSP-90, interleukin-10, and FOXP3 and also inhibit interleukin-6, peptidoglycan, flagellin, and dectin in silico. Conclusion MLE of A. corniculatum has antioxidant, anti-inflammatory, and antibacterial activities that can be a potential raw material for developing a herbal-based mouthwash.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…BMDCs were grown from wild-type C57BL/6 mice (Orient Bio Inc., Seoul, Korea) [ 31 , 32 ]. All animal procedures were approved by and performed according to the guidelines of the Institutional Animal Care and Use Committee of Jeju National University (#2016-0059).…”

Section: Methodsmentioning

confidence: 99%

“…Supernatants were harvested 18 h after stimulation. Concentrations of murine IL-12 p40, IL-6, and TNF-α in the culture supernatants were determined by ELISA (BD PharMingen, San Diego, CA, USA) following the manufacturer’s protocol [ 31 , 32 ]. All experiments were carried out at least three times.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effects of Cucurbitane-Type Triterpenoids from Momordica charantia Fruit on Lipopolysaccharide-Stimulated Pro-Inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

et al. 2021

Self Cite

View full text Add to dashboard Cite

The bitter melon, Momordica charantia L., was once an important food and medicinal herb. Various studies have focused on the potential treatment of stomach disease with M. charantia and on its anti-diabetic properties. However, very little is known about the specific compounds responsible for its anti-inflammatory activities. In addition, the in vitro inhibitory effect of M. charantia on pro-inflammatory cytokine production by lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) has not been reported. Phytochemical investigation of M. charantia fruit led to the isolation of 15 compounds (1−15). Their chemical structures were elucidated spectroscopically (one- and two-dimensional nuclear magnetic resonance) and with electrospray ionization mass spectrometry. The anti-inflammatory effects of the isolated compounds were evaluated by measuring the production of the pro-inflammatory cytokines interleukin IL-6, IL-12 p40, and tumor necrosis factor α (TNF-α) in LPS-stimulated BMDCs. The cucurbitanes were potent inhibitors of the cytokines TNF-α, IL-6, and IL-12 p40, indicating promising anti-inflammatory effects. Based on these studies and in silico simulations, we determined that the ligand likely docked in the receptors. These results suggest that cucurbitanes from M. charantia are potential candidates for treating inflammatory diseases.

show abstract

“…Several in vitro studies signified the pragmatic activities of different mangrove extracts against human colorectal cancer, [96] breast cancer, [64,97,98] cervical cancer, [97] gastric cancer, [97] liver cancer, [81] skin cancer, [83] lung cancer, [99] and leukaemia. [43] Diverse phytochemicals with potential anticancer and cytotoxic activities were also isolated time to time from A. corniculatum, [100,101] A. marina, [41,102] C. decandra [103] and E. agallocha. [104]…”

Section: Anticancer Activity and Cytotoxicitymentioning

confidence: 99%

“…[87] Methanol extract of R. mucronata leaves also exhibited potential activity. [110] Potential anti-inflammatory compounds were isolated from A. corniculatum leaves, [101] which inhibited cytokines TNF-α, IL-6, and IL-12 p40. Bark extracts of C. decandra potentially reduced carrageenan-induced oedema up to 67 %.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Bhitarkanika National Park is the second largest contiguous mangrove forest of India. Approximately 0.15 million mangrove depending population are found residing in and around 307 villages within the National Park. Despite being one of the most diverse mangrove habitations of India, the ethnopharmacological practices are meager in comparison to the other mangrove regions of India and Southeast Asia. The present review is aimed to congregate information on the therapeutic potential and ethnopharmacology of nine dominant mangrove species of the National Park, such as Aegiceras corniculatum, Avicenia marina, Avicenia officinalis, Ceriops decandra, Excoecaria agallocha, Heritiera fomes, Lumnitzera racemosa, Rhizophora mucronata, and Sonneratia apetala. Our aim is to generate social awareness among the mangrove dwellers to promote uses of folklore medicine using these tremendously potential mangrove plants, as a complementary step to strengthen community health. Further, we also want to grab the attention of researchers working in related disciplines, for their holistic and extensive studies towards bio-prospectation of the dominant mangrove plants of Bhitarkanika National Park.

show abstract

Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum

Cited by 16 publications

References 18 publications

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

Inhibitory Effects of Cucurbitane-Type Triterpenoids from Momordica charantia Fruit on Lipopolysaccharide-Stimulated Pro-Inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Contact Info

Product

Resources

About