Isolation of β-Asarone from Acorus Calamus Linn. And Evaluation of its Anticonvulsant Activity using MES and PTZ Models in Mice

Chromatographic Fingerprinting of Sarasvata Churna-an Ayurvedic Polyherbal Formulation for Epilepsy

“…There are scientific evidences that show that the components of Sarasvata churna volatile oil posses significant antioxidant, anticonvulsant and other neuroprotective activity which further strengthens the scientific basis of this ancient antiepileptic formulation. Many components of the volatile oil like β-Caryophyllene (Oliveira et al, 2016), β-Asarones (Kaushik et al, 2017b;Jayaraman et al, 2010), Copaene, α-Sesquiphellandrene and gingerols (Hussein et al, 2015) α-pinene, p-cymene (Talita et al, 2015), γ-terpinene etc were present in significant concentrations which contributes to antiepileptic potential of Sarasvata churna. HPTLC fingerprinting of the polyherbal formulations is one of the important parameters for accurate and scientific standardization.…”

“…In last three decades, there have been tremendous increases in consumption of herbal medicines due to high cost, toxicity, and failure of modern systems of medicines. Ancient Ayurvedic text Sarangdhar Samhita emphasizes the use of Polyherbalism in the long-term management of diseases (Kaushik et al, 2017a). Polyherbal formulations contain a large number of bioactive principles contributed by the ingredient herbs in very low concentrations which makes the formulation to act on a disorder by multiple mechanisms of actions along with low toxicity and least side effects.…”

“…Sarasvata churna contains herbs like Bacopa monnieri (Brahmi), Convolvulous pluricaulis (Shankhpushpi), Acorus calamus (Vach), Cissampelos pareira (Patha), Piper longum (Peepli), Piper nigrum (Kalimirch), Sassurea lappa (Kustha), Withania somnifera (Ashwagandha), Rock salt (Lavana), Carum roxburghianum (Ajmod), Carum carvi (Kala Jeera), Cuminum cyminum (Safed Jeera) and Zingiber Officinalis (Sonth). Withanolides (Kulkarni et al, 2008;Candelario et al, 2015) of Withania somnifera, Bacosides (Paturu et al, 2013;Tripathi et al, 1996) of Bacopa monneire Asarones of Acorus calamus (Kaushik et al, 2017;Jayaraman et al, 2010) Piperine of Piper nigrum and Piper longum (Mishra et al, 2015;Syed et al, 2015), Sesquiterpenes and Gingerols (Hussein et al, 2015) from Zingiber officinalis, Pinene, Thymol, Caryophyllene (Oliveira et al, 2016), Sesquiphellandrene, Copaene, Cymene (Talita et al, 2015) and many other volatile principles from Carum carvi, Carum roxburghianum, Cuminum cyminum (Janahmadi et al, 2006;Sayyah et al, 2002) and Sassurea lappa posses significant antioxidant, antiepileptic and neuroprotective potentials (Kaushik et al, 2017b). Physicochemical analysis of Sarasvata churna revealed the presence of alkaloids, glycosides, tannins, flavonoids, terpenoids, proteins, carbohydrates, fats and oils.…”

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

“…The calamus oil was found to be neurotoxic at 300 mg/kg, though it was effective in the MCS test at 6 Hz. The protective index value of calamus oil was found to be 4.65 [125].…”

“…Triterpenoid saponins are made up of a pentacyclic C-30 terpene skeleton as a pillar. Limited reports studying triterpenoid saponins in A. calamus are available, and only two triterpenoid saponins (124,125) have been isolated from A. calamus rhizomes (Table 3) [85].…”