Isolation of Histoplasma capsulatum from an armadillo (Dasypus novemcinctus) in the eastern Amazon of Brazil

Árias, Jorge R.; Naiff, R. D.; Naiff, Maricleide de Farias; Mok, Wai Yin; Almeida, Margarida Maria Roque

doi:10.1016/0035-9203(82)90253-x

Cited by 18 publications

(7 citation statements)

References 7 publications

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“…33,36 In the biodiversity of Latin America fauna, of the actual 20 known armadillo's species, 17 are only found in Brazil and have been little studied. It has been shown that these animals can be natural carriers of important pathogens such as Trypanosoma cruzi, 37,38 Histoplasma capsulatum, 39 Leishmania naiffi, 40 Toxoplasma gondii, 41 and Paracoccidioides brasiliensis. [42][43][44] The nine-banded armadillos, family Dasypodidae, order Cingulata, Superorder Xenarthra, 13 were introduced in North America very recently, around the year 1880.…”

Section: Discussionmentioning

confidence: 99%

Search for Mycobacterium leprae in wild mammals

Pedrini¹,

Rosa²,

Medri³

et al. 2010

Braz J Infect Dis

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Leprosy is still a worldwide public health problem. Brazil and India show the highest prevalence rates of the disease. Natural infection of armadillos Dasypus novemcinctus with Mycobacterium leprae has been reported in some regions of the United States. Identification of bacilli is difficult, particularly due to its inability to grow in vitro. The use of molecular tools represents a fast and sensitive alternative method for diagnosis of mycobacteriosis. In the present study, the diagnostic methods used were bacilloscopy, histopathology, microbiology, and PCR using specific primers for M. leprae repetitive sequences. PCR were performed using genomic DNA extracted from 138 samples of liver, spleen, lymph nodes, and skin of 44 D. novemcinctus, Euphractus sexcinctus, Cabassous unicinctus, and C. tatouay armadillos from the Middle Western region of the state of São Paulo and from the experimental station of Embrapa Pantanal, located in Pantanal da Nhecolândia of Mato Grosso do Sul state. Also, the molecular analysis of 19 samples from internal organs of other road killed species of wild animals, such as Nasua nasua (ring-tailed coati), Procyon cancrivoros (hand-skinned), Cerdocyon thous (dog-pity-bush), Cavia aperea (restless cavy), Didelphis albiventris (skunk), Sphigurrus spinosus (hedgehog), and Gallictis vittata (ferret) showed PCR negative data. None of the 157 analyzed samples had shown natural mycobacterial infection. Only the armadillo inoculated with material collected from untreated multibacillary leprosy patient presented PCR positive and its genomic sequencing revealed 100% identity with M. leprae. According to these preliminary studies, based on the used methodology, it is possible to conclude that wild mammals seem not to play an important role in the epidemiology of leprosy in the Middle Western region of the São Paulo state and in the Pantanal of Mato Grosso do Sul state.

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Section: Discussionmentioning

confidence: 99%

Search for Mycobacterium leprae in wild mammals

Pedrini¹,

Rosa²,

Medri³

et al. 2010

Braz J Infect Dis

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“…Os tatus ainda são conhecidos por abrigar diversos agentes patogênicos, sendo considerado "sentinela" para pesquisa do nicho ecológico, entre eles Trypanossoma cruzi (Barreto, 1963;Kluyber, 2016;Lainson et al, 1979), Toxoplasma gondii (Kluyber, 2016;Sogorb et al, 1977), Leishmania naiffi (Naiff et al, 1991), espécies de Sarcocystis e Eimeria, Piroplasma (Diniz et al, 1997), Nocardia brasiliensis (Gezuele, 1972), Sporothrix schenckii (Kaplan et al, 1982), Histoplasma capsulatum var. capsulatum (Arias et al, 1982), Coccidioides immitis (Eulalio et al, 2001), Paecilomyces lilacinus (Gordon, 1984;Vergara & Martinez, 1998) Leptospira sp., Paracoccidioides brasiliensis (Bagagli et al, 1998;Kluyber, 2016;Naiff, 1986) e Mycobacterium leprae de forma natural e experimental (Deps et al, 2003;Loughry et al, 2009;Morgan & Loughry, 2009;Opromolla et al, 1980;Pedrini, 2007;Perez-Heydrich et al, 2016;Rosa et al, 2005). Todavia, não está esclarecido todo seu potencial de transmissão zoonótico (Deps et al, 2003).…”

Section: Aspectos Biológicosunclassified

Aspectos biológicos y nutricionales de Dasypus novemcinctus (Linnaeus, 1758)

Testa

Hippólito

Santos

et al. 2019

Pubvet

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Os tatus (Dasypus novemcinctus) são animais terrestres, solitários e de hábito crepuscular/noturno. Representam a maior espécie do gênero Dasypus, com ampla distribuição geográfica e são conhecidos por abrigar diversos agentes patogênicos, além de atuar como bioindicadores de doenças potencialmente patogênicas aos humanos. Deste modo, são muito utilizados para a pesquisa científica relacionada à saúde humana. Alimentam-se principalmente de insetos, sendo considerados animais insetívoros oportunistas, mas consomem também outros itens alimentares, como frutos, pequenos vertebrados, ovos, carniça, fungos, apresentando uma variabilidade sazonal na ingestão de alimentos, assim buscando alimento ao longo de todo o ano. Apesar de não constarem em lista de espécies ameaçadas, sofrem ameaças constantes em toda a sua extensão territorial, sendo cada vez mais encaminhados a centros de reabilitação e manutenção de animais silvestres. E mesmo sendo mantidos sob cuidados humanos para pesquisa científica relacionadas com a saúde humana, há pouco conhecimento biológico sobre a espécie, principalmente em relação às suas necessidades nutricionais e à criação artificial de filhotes. Portanto, o objetivo desta revisão bibliográfica foi reunir as informações sobre a biologia, os aspectos nutricionais e de criação artificial de tatus. A pesquisa inferiu que ainda há muitos pontos sobre a espécie que precisam de maiores investigações, principalmente quando relacionados à nutrição ex-situ e criação artificial.

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“…In the Americas, bats are frequently and commonly infected with H. capsulatum (Taylor et al, 1999) with histoplasmosis having been reported in Desmodus rotundus (Veloso et al, 2014), Molossus molossus (Dias et al, 2011;dos Santos et al, 2018;Veloso et al, 2014), Tadarida brasiliensis (González-González et al, 2014;Teixeira et al, 2016;Veloso et al, 2014), Molossus rufus, Nyctinomops macrotis (Dias et al, 2011), Histiotus velatus (Veloso et al, 2014) Almeida, 1982), opossum (Didelphis marsupialis), paca (Agouti paca) (Naiff, Mok, & Naiff, 1985), sloth (Choloepus didactylus) and spiny rat (Proechimys guyanensis) (Lainson & Shaw, 1975). Hence, to the best of our knowledge, the present study is the first to report H. capsulatum infection in Carollia perspicillata and in Vampyriscus bidens.…”

Section: Discussionmentioning

confidence: 99%

“…The Brazilian Amazon region has a wide diversity of chiroptera species; however, to date, there were no reports of H. capsulatum research in bats of this region. Earlier reports of H. capsulatum in this region date from several decades ago and pertain to other wild mammals, such as armadillo ( Dasypus novemcinctus ) (Arias, Naiff, Naiff, Mok, & Almeida, 1982), opossum ( Didelphis marsupialis ), paca ( Agouti paca ) (Naiff, Mok, & Naiff, 1985), sloth ( Choloepus didactylus ) and spiny rat ( Proechimys guyanensis ) (Lainson & Shaw, 1975). Hence, to the best of our knowledge, the present study is the first to report H. capsulatum infection in Carollia perspicillata and in Vampyriscus bidens .…”

Section: Discussionmentioning

confidence: 99%

Molecular detection ofHistoplasma capsulatumin bats of the Amazon biome in Pará state, Brazil

Silva

Scofield

Barros

et al. 2020

Transbounding Emerging Dis

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Histoplasma capsulatum is a dimorphic fungus growing in soils, bat guano and bird faeces (Aidé, 2009;Kauffman, 2007). Its dimorphism is induced by temperature variations during its growth phase. Histoplasma capsulatum growth involves a filamentous phase and a yeast phase, and the transition from the former to the latter entails changes in both cell form and cell wall composition. This transformation determines the virulence of dimorphic fungi such as H. capsulatum (Klein & Tebbets, 2007).Histoplasma capsulatum has three distinct variants based on morphology and geographic distribution. Histoplasma capsulatum var. capsulatum is pathogenic to humans, H. capsulatum var. duboisii causes disease in primates, and H. capsulatum var. farciminosum

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Isolation of Histoplasma capsulatum from an armadillo (Dasypus novemcinctus) in the eastern Amazon of Brazil

Cited by 18 publications

References 7 publications

Search for Mycobacterium leprae in wild mammals

Search for Mycobacterium leprae in wild mammals

Aspectos biológicos y nutricionales de Dasypus novemcinctus (Linnaeus, 1758)

Molecular detection ofHistoplasma capsulatumin bats of the Amazon biome in Pará state, Brazil

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