Two outbreaks of trypanosomiasis by

Histoplasma capsulatum is a dimorphic fungus growing in soils, bat guano and bird faeces (Aidé, 2009;Kauffman, 2007). Its dimorphism is induced by temperature variations during its growth phase. Histoplasma capsulatum growth involves a filamentous phase and a yeast phase, and the transition from the former to the latter entails changes in both cell form and cell wall composition. This transformation determines the virulence of dimorphic fungi such as H. capsulatum (Klein & Tebbets, 2007).Histoplasma capsulatum has three distinct variants based on morphology and geographic distribution. Histoplasma capsulatum var. capsulatum is pathogenic to humans, H. capsulatum var. duboisii causes disease in primates, and H. capsulatum var. farciminosum