Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

Nogata, Yoichi; Ohta, Hiroyuki; Ishii, Toshinao; Sekiya, Keizo

doi:10.1002/jsfa.2674

Cited by 16 publications

(10 citation statements)

References 32 publications

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“…The cytoprotective effect found in our assays was reasonably well correlated with the amounts of flavanones (0.803), which could explain the high activity of M. aquatica hydroethanolic extract, mainly composed of eriodictyol-7- O -rutinoside. In fact, it has been described that this compound has a lipoxygenase inhibitor action [45], and eriodictyol has been reported to reduce NO • production in macrophages [27,46]. Previous studies have also shown the efficacy of eriodictyol in ROS scavenging activity in HepG2 [30] and retinal cells [47].…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

et al. 2019

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The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro. L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.

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Section: Resultsmentioning

confidence: 99%

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

et al. 2019

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“…The peels were removed, shade dried, and powdered. Extraction procedure was targeted to obtain flavonoids as followed by Nogata et al (2007). Lemon peels (100 g) were first extracted with n-hexane and the residue was further extracted with chloroform followed by hot ethanol.…”

Section: Preparation Of Lp Extractmentioning

confidence: 99%

Beneficial effect ofCitrus limonpeel aqueous methanol extract on experimentally induced urolithic rats

Sridharan

Michael

Arya

et al. 2015

Pharmaceutical Biology

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“…Signals at δ 6.92 (d, J = 1.5 Hz) for H-2 , 6.89 (dd, J = 1.5, 8. [27,28]. This is the first time reporting the isolation of eriodictioside from C. macrocarpa leaves.…”

Section: Discussionmentioning

confidence: 80%

Elucidation of Phytochemical Content of Cupressus macrocarpa Leaves: In Vitro and In Vivo Antibacterial Effect against Methicillin-Resistant Staphylococcus aureus Clinical Isolates

et al. 2021

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Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that causes various infections. The increasing resistance of MRSA to different antibiotics is widely spreading; therefore, plant extracts may be novel therapeutic alternatives. The phytochemical profiling of Cupressus macrocarpa Hartw. ex Gordon leaves in vitro, and in vivo, antimicrobial potential of its extracts against MRSA clinical isolates were explored. A phytochemical tentative identification of 49 compounds was performed in the leaves using LC-ESI-MS/MS; in addition, isolation, and structure elucidation of hesperidin and eriocitrin were achieved for the first time. The diethyl ether extract (DEEL) exhibited the best antibacterial effect with MIC values ranging from 2 to 8 µg/mL, which significantly reduced the growth and efflux activity in 48.78% and 29.26% of isolates, respectively. qRT-PCR showed a significant down expression of norA and norB genes, which significantly affected the bacterial cell morphology and had a non-significant effect on membrane depolarization (using flow cytometry). In a rat model, four groups were wounded and treated with normal saline or DEEL, or infected with MRSA, or infected and treated with DEEL. The regeneration of the epidermis, maturation of granulation tissue, and reduction of inflammatory cell infiltration were observed after treatment with DEEL. Thus, C. macrocarpa leaves may be a promising source for new antimicrobials against MRSA.

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Isolation of eriocitrin (eriodictyol 7‐O‐rutinoside) as an arachidonate lipoxygenase inhibitor from Lumie fruit (Citrus lumia) and its distribution in Citrus species

Cited by 16 publications

References 32 publications

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

Beneficial effect ofCitrus limonpeel aqueous methanol extract on experimentally induced urolithic rats

Elucidation of Phytochemical Content of Cupressus macrocarpa Leaves: In Vitro and In Vivo Antibacterial Effect against Methicillin-Resistant Staphylococcus aureus Clinical Isolates

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