Isolation of Aristolochic Acid in<i>Aristolochia maurorum</i>(Aristolochiaceae)

Kéry, Ágnes; Askari, Ali; Sharefi, K. A.

doi:10.3109/13880208309070628

Cited by 5 publications

(3 citation statements)

References 4 publications

(3 reference statements)

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“…The analysis of aristolochic acids I and II by LC/UV has been well studied8,, 9 and thin‐layer chromatography methods are also available 10. LC/UV can be used to detect aristolochic acids in crude methanol extracts of Aristolochia species, without sample clean‐up to remove interfering compounds, as the levels of aristolochic acids are relatively high 11,.…”

mentioning

confidence: 99%

Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry

Kite

Yule

Léon

et al. 2002

Rapid Comm Mass Spectrometry

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Targeted liquid chromatography/serial mass spectrometry (LC/MS/MS) analysis, using a quadrupole ion-trap mass spectrometer, permitted the detection of aristolochic acids I and II in crude 70% methanol extracts of multi-component herbal remedies without any clean-up or concentration stages. The best ionisation characteristics were obtained using atmospheric pressure chemical ionisation (APCI) and by including ammonium ions in the mobile phase. Limits of detection for aristolochic acids were influenced by the level of interference created by other components in the sample matrix. They were determined to be between 250 pg and 2.5 ng on-column within a matrix containing compounds extracted from 2 mg of herbal remedy. With a herbal remedy that only permitted the higher limit of detection, this sensitivity was sufficient to detect the aristolochic acids extracted from 0.1% dry weight of Aristolochia manshuriensis included in the preparation.

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confidence: 99%

Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry

Kite

Yule

Léon

et al. 2002

Rapid Comm Mass Spectrometry

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“…SOURCES: ARISTOLOCHIACEAE: Arts to lochia acuminata (43), argentina (51,56), badamae (60), baetica (6), bracteata (26,27,42,58), chilensis (72), clematitis (5,9,20,21,23,47,48,50,52,59,60), debilis (29,65,69,71), elegans (60), esperanzae (51), fangchi (10,62,66), fimbriata (60), graffithii (64), indica (14,15,18,33,34,49,63), kaempferi (65), kwangsiensis (11,39), longa (15,21,61), manshuriensis (44, 54), maurorum (28), maxima (21), mollissima (17, 24), multiflora (43), ornithocephala (60), pandurata (21), reticulata…”

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The Aristolochic Acids and Aristolactams

Mix¹,

Guinaudeau²,

Shamma³

1982

J. Nat. Prod.

114

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“…Literature reviews report a variety of chemical compounds identified from the genus Aristolochia (Hong et al, 1994;Achenbach and Fischer, 1997; 0939Ð5075/2006/0900Ð0685 $ 06.00 " 2006 Verlag der Zeitschrift für Naturforschung, Tübingen · http://www.znaturforsch.com · D Wu et al, 1994Wu et al, , 1999Kery et al, 1983) Ð aristolochic acids, which are a group of substituted 1-phenanthrenecarboxylic acids, in particular aristolochic acid I and II, are the major constituents (Budavri et al, 1996).…”

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confidence: 97%

Phytochemical and Biological Investigation of Aristolochia maurorum L.

Alali

Tawaha

Shehadeh

et al. 2006

Zeitschrift Für Naturforschung C

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Aristolochia maurorum L. of Jordanian origin has been investigated phytochemically, quantitatively, and biologically. Three atypical alkaloids, namely aristolochic acid I (1), aristolochic acid II (2) and aristolochic acid IIIa (3), have been isolated and identified. Of these known 1-phenanthrenecarboxylic acids, 2 and 3 are reported for the first time from this species. The identified compounds 1Ð3 were first evaluated biologically as cytotoxic agents against the brine shrimp lethality test (BST), in which compound 1 was found to be the most potent (LC 50 , 4.9 μg/mL). The antiplatelet activity of the methanolic extracts, the acidic fractions of aerial and root parts, and the identified compounds 1Ð3 were evaluated using an automatic platelet aggregometer and coagulation tracer (APACT 2). Using external reference standards, and a reverse-phase isocratic method, the distribution of aristolochic acid I and aristolochic acid II in different plant parts of Aristolochia maurorum L. during flowering stage was analyzed by PDA-HPLC. A quantitative comparison between two previously reported extraction methods was also made. Roots were found to be the main storage of aristolochic acid I and aristolochic acid II during flowering stage with about 0.22 and 0.108% (w/w), respectively.

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Isolation of Aristolochic Acid inAristolochia maurorum(Aristolochiaceae)

Cited by 5 publications

References 4 publications

Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry

Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry

The Aristolochic Acids and Aristolactams

Phytochemical and Biological Investigation of Aristolochia maurorum L.

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