Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Yeşilada, Erdem; Gürbüz, İlhan; Bedir, Erdal; Tatlı, I. İrem; Khan, Ikhlas A.

doi:10.1016/j.jep.2004.07.021

Cited by 47 publications

(39 citation statements)

References 16 publications

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“…Several species from the genus Centaurea are interesting from medicinal and pharmacological perspective, and thus recently the subject of intensive research [3][4][5][6][7][8][9][10][11][12][13][14]. Since structural and phytochemical characteristics of C. sadleriana were previously unknown, our work highlights this information.…”

Section: Discussionmentioning

confidence: 98%

“…In the flora of Europe and Serbia, 221 species and 32 species have been recorded, respectively [1,2]. Ethnopharmacological studies reveal that many species were well known for their use in traditional medicine and for treatment of various diseases [3][4][5]. Owing to their potential use in medicine, secondary metabolites isolated from Centaurea species, as well as their biological activities, were the subject of numerous investigations.…”

Section: Introductionmentioning

confidence: 99%

“…As Centaurea species were generally classified as essential oil-poor plants, the investigations of these and antioxidant properties are rather scarse. However, antiinflammatory, antimicrobial, antifungal and cytotoxic activities had been found for extracts or natural products of some of the Centaurea species [3,[5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Anatomical characteristics and antioxidant ability of Centaurea sadleriana reveals an adaptation towards drought tolerance

et al. 2013

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The lamina, main vein and peduncle anatomical properties of Centaurea sadleriana Janka plants from two populations, were examined using light and scanning electron microscopy. The indumentum was comprised of glandular and non-glandular trichomes of two types. The leaves were amphistomatic, isolateral, with strongly developed palisade tissue. Secretory ducts were observed along the phloem or sclerenchyma of large vascular bundles. Collenchyma alternated with chlorenchyma in the main vein and peduncle. Large groups of strongly lignified sclerenchyma were present along the phloem of peduncle vascular bundles. These features, together with thickened walls of epidermal cells and cuticle, numerous trichomes and thick-walled parenchyma in the perimedullar zone, were perceived as a xeromorphic peduncle structural adaptation. Non-enzymatic antioxidant compounds of phenolic origin were detected in small amounts and their respective content was higher in leaves compared to inflorescences. Compounds of phenolic orgin showed positive correlation with total potenial of antioxidant activity indicated by the DPPH assay. Greater total quantity of polyphenols and tannins was detected in leaves of plants from Zobnatica locality, while leaves of plants from Rimski Sanac were characterized by higher content of total flavonoids and proantocyanidins. Phytochemical analysis showed that dominant secondary biomolecules in inflorescences were phenolic pigments including anthocyanins and leucoanthocyanins, and free quinones in leaves.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anatomical characteristics and antioxidant ability of Centaurea sadleriana reveals an adaptation towards drought tolerance

et al. 2013

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“…solstitialis responsible for its significant anti-ulcerogenic activity were determined as solstitialin A (181), 13-acetyl solstitialin A (183) and chlorojanerin (219) (Yesilada et al, 2004;Gürbüz and Yesilada, 2007).…”

Section: Other Activitiesmentioning

confidence: 99%

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

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“…In this mechanism of cyto-protection, antioxidant activity might be mediated by the reaction between the electrophilic acceptor, trans-cinnamic acid, (which constitute 21.9% of isolated compounds) from the EAF with sulfhydryl-containing compounds of the gastric mucosa (Marıa et al, 2000)[79]. Trans-cinnamic acid (Michael's acceptor) and electron donation by sulphydryl moiety present in proteins or oxidants containing compounds has form a new basis of cytoprotection (Souza-Brito et al, 1998;HirumaLima et al, 1999;Hiruma-Lima et al, 2001;Melo et al, 2003;Yesilada et al, 2004;Hamauzu et al, 2008). These results, taken together, suggest that the EAF active compounds mechanism of RSA is yet to be elucidated; but may be mediated by trans-cinnamic acid (Michael's acceptor) interaction with oxidants.…”

Section: Dietary Polyphenols Has Protective Effects Against Various Dmentioning

confidence: 99%

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Nwidu¹

2012

J. App. Pharm. Sci.

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Carpolobia lutea leaves (CLL) (Polygalaceae) were earlier screened and the antiulcer ethnomedicinal claim established. This article seeks to quantitatively isolate, elucidate the active compounds from most active CLL fraction. Fractionation was by semi-preparative HPLC; the active fraction was subjected to radical scavenging assays (RSA) and quantification of the total phenolic content (TPC) were also executed. Results: Ethyl acetate fraction (EAF) was observed to be the most pharmacologically active antiulcer fraction when screened using acute ulcer models induced in rodents. The EAF demonstrated significant (p < 0.05-0.001) antiulcer activity in various in vivo induced ulceration models by reducing the ulcer index and increasing the preventive ratio. The EAF demonstrated > 70% in TPC and < 20 % in RSA. Cinnamic and coumaric acids derivatives were isolated from EAF. Cinnamic acids have been implicated and patented as antiulcer agent. Isolated compounds could in part mediate the observed pharmacological activities which lend credence to its ethnobotanical uses.

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Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Cited by 47 publications

References 16 publications

Anatomical characteristics and antioxidant ability of Centaurea sadleriana reveals an adaptation towards drought tolerance

Anatomical characteristics and antioxidant ability of Centaurea sadleriana reveals an adaptation towards drought tolerance

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

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