Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Bruno, Maurizio; Bancheva, Svetlana; Rosselli, Sergio; Maggio, Antonella

doi:10.1016/j.phytochem.2013.07.002

Cited by 72 publications

(46 citation statements)

References 371 publications

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“…28 Since mediaeval times, preparations of blessed thistle (e.g., bitter tonics) have been used to treat various _________________________________________________________________________________________________________________________ (CC) 2014 SCS. All rights reserved.…”

Section: Resultsmentioning

confidence: 99%

Secondary metabolites of three endemic Centaurea L. species

Tešević

Aljančić²,

Milosavljević

et al. 2014

JSCS

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The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, 1 H-NMR and 13 C-NMR spectroscopy and HR-ESI-MS spectrometry. 1 H--NMR spectroscopy was used as a method for the quantitative analysis of cnicin.

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Section: Resultsmentioning

confidence: 99%

Secondary metabolites of three endemic Centaurea L. species

Tešević

Aljančić²,

Milosavljević

et al. 2014

JSCS

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“…Centaurea species have been the object of various phytochemical studies, with a diversity of bioactive phytochemicals and prevalence of flavonoids 2 , flavonoid aglycones 3 , lignans 4 , sesquiterpene lactones 5 , essential oils 6 , alkaloids 7 and other biologically active constituents. Some species of the genus Centaurea have been used as medicinal plants in folk medicine for their uses in gastrointestinal 8 and inflammatory disorders 9 , cytotoxic activity 4,10 , in addition to the anti-microbial 11,12 and antioxidant activities 13 .…”

Section: Genusmentioning

confidence: 99%

Phenolic Compounds and Hepatoprotective Activity of Centaurea aegyptiaca L. on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Senosy

Kamal

El‐Toumy

et al. 2018

Journal of Advanced Pharmacy Research

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Objectives: This study aimed to isolate phenolic compounds from the 70% aqueous methanol extract of the aerial parts (leaves, flowers and stems) of Centaurea aegyptiaca , evaluate in-vivo hepatoprotective activity and determine total phenolic and total flavonoid contents. Methods: 70% aqueous methanol extract of the aerial parts subjected to different chromatographic separation techniques. The identities of the isolated compounds were established on the basis of their spectral data and comparing with previously reported data. The crude extract was evaluated for invivo hepatoprotective activity on CCl4-induced hepatotoxicity in rats. Total phenolic and total flavonoid contents of the aqueous methanol extract were determined using Folin-Ciocalteu and aluminum chloride colorimetric methods, respectively. Results: The aqueous methanol extract of the aerial parts of Centaurea aegyptiaca afforded seven compounds. A phenolic acid ester; protochatechuic acid methyl ester (1) along with six known flavonoids; apigenin-6-C-β-D-glucopyranoside (isovitexin) (2), apigenin-8-C-β-D-glucopyranoside (vitexin) (3), quercetin-3-O--Dglucopyranoside (isoquercetin) (4), apigenin (5), 3-O-methylquercetin (6) and quercetin (7). Administration of the extract at doses of 100 and 200 mg/kg b.wt showed a hepatoprotective activity similar to that of the standard drug; silymarin at a dose of 25 mg/kg b.wt. Comparative histopathological study of liver exhibited moderate changes in liver histoarchitecture when compared to the CCl4 group. The methanolic extract showed high concentration of phenolic and flavonoid contents. Conclusion: The aqueous methanol extract of the aerial parts of C. aegyptiaca afforded seven phenolic compounds for the first time from this species, with promising in-vivo hepatoprotective activity.

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“…Cytotoxic properties of the Centaurea plant extracts are usually related to their chemical composition. The majorities of compounds in aqueous extracts (AE) belong, but are not limited to the groups of sesquiterpene lactones (SQLs), acetylenes, phenolics, flavonoids, glycosides, lignans, coumarines, and others . Sesquiterpene lactones, phenols, flavonoids, and lignans are usually regarded as a group of compounds responsible for diverse biological activity of Centaurea plant extracts.…”

Section: Introductionmentioning

confidence: 99%

Qualitative HPLC‐DAD/ESI‐TOF‐MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts

Radan

Carev

Tešević

et al. 2017

Chemistry & Biodiversity

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Centaurea ragusina L., an endemic Croatian plant species, revealed a good cytotoxic activity of aqueous extracts (AE) on human bladder (T24) and human glioblastoma (A1235) cancer cell lines. The chemical constituents were tentatively identified using high performance liquid chromatography HPLC-DAD/ESI-TOF-MS in negative ionization mode. The main compounds of herba extract were sesquiterpene lactones: solstitialin A 3,13-diacetate and epoxyrepdiolide; organic acid: quinic acid. The main compounds of flower extract were organic acids: quinic acid, citric acid, and malic acid; sesquiterpene lactone: cynaropicrin; phenolic compounds: chlorogenic acid and phenylpropanoid: syringin. The AE of C. ragusina were investigated for correlation of their effects on human bladder (T24) and human glioblastoma (A1235) cancer cell lines using the MTT assay. Although both extracts showed significant dose- and time-dependent cytotoxic activity against both cancer cell lines, the flower extract exhibited slightly higher activity. In order to determine type of cell death induced by treatment, cell lines were exposed subsequently to a treatment with both flower and herba AE. The majority of the cells died by induced apoptosis treatment. Flower AE (26.25%), compared to a leaf AE (22.15%) showed slightly higher percentage of an apoptosis in T24 cells, when compared to a non-treated cells (0.04%).

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Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Cited by 72 publications

References 371 publications

Secondary metabolites of three endemic Centaurea L. species

Secondary metabolites of three endemic Centaurea L. species

Phenolic Compounds and Hepatoprotective Activity of Centaurea aegyptiaca L. on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Qualitative HPLC‐DAD/ESI‐TOF‐MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts

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