Isolation, characterization and insect growth inhibitory activity of major turmeric constituents and their derivatives against Schistocerca gregaria (Forsk) and Dysdercus koenigii (Walk)

Chowdhury, Hemanta; Walia, Suresh; Saxena, V. S.

doi:10.1002/1526-4998(200012)56:12<1086::aid-ps250>3.3.co;2-o

Cited by 15 publications

(16 citation statements)

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“…Turmeric oil produced 10% growth inhibition and 60% nymphal mortality at the same dosage. Topical application of a dosage of 50 μg of curcuminoids (I, II, and III) produced 45% growth inhibition of D. koenigii nymphs52.…”

Section: Resultsmentioning

confidence: 99%

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Tavares

Akhtar

Gonçalves

et al. 2016

Sci Rep

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Curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on Trichoplusia ni is unknown. In this study, the compound ar-turmerone, extracted and purified from C. longa rhizomes, was identified, and its insecticidal effects, along with turmeric powder, curcuminoid pigments and crude essential oil were evaluated against this important agricultural pest. The role of natural (sesamol and piperonal) and synthetic [piperonyl butoxide (PBO)] synergists under laboratory and greenhouse conditions were also evaluated. The concentration of ar-turmerone in C. longa rhizomes harvested was 0.32% (dwt). Turmeric powder and its derivatives caused 10–20% mortality in third instar T. ni at a very low dose (10 μg/larva). Addition of PBO increased toxicity of turmeric powder and its derivatives (90–97% mortality) in most binary combinations (5 μg of turmeric powder or its derivatives +5 μg of PBO), but neither piperonal nor sesamol were active as synergists. The compound ar-turmerone alone and the combination with PBO reduced larval weight on treated Brassica oleracea in the laboratory and in greenhouse experiments, compared with the negative control. The compound ar-turmerone could be used as a low cost botanical insecticide for integrated management of cabbage looper in vegetable production.

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Section: Resultsmentioning

confidence: 99%

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Tavares

Akhtar

Gonçalves

et al. 2016

Sci Rep

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“…2D (inset). Such assignments are based on comparisons with MS/MS spectra of the structural analogue of dimethoxycurcumin, curcumin, and previously reported results on the mass fragmentation pattern of curcumin (41,42). It is possible to select ions shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Tamvakopoulos

Dimas

Sofianos

et al. 2007

Clinical Cancer Research

180

146

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Purpose: The plant-derived compound curcumin has shown promising abilities as a cancer chemoprevention and chemotherapy agent in vitro and in vivo but exhibits poor bioavailability. Therefore, there is a need to investigate modified curcumin congeners for improved anticancer activity and pharmacokinetic properties. Experimental Design: The synthetic curcumin analogue dimethoxycurcumin was compared with curcumin for ability to inhibit proliferation and apoptosis of human HCT116 colon cancer cells in vitro by estimating the GI 50 and LC 50 values and detecting the extent of apoptosis by flow cytometry analysis of the cell cycle. Metabolic stability and/or identification of metabolites were evaluated by recently developed mass spectrometric approaches after incubation with mouse and human liver microsomes and cancer cells in vitro. Additionally, circulating levels of dimethoxycurcumin and curcumin were determined in mice following i.p. administration. Results: Dimethoxycurcumin is significantly more potent than curcumin in inhibiting proliferation and inducing apoptosis in HCT116 cells treated for 48 h. Nearly 100% of curcumin but <30% of dimethoxycurcumin was degraded in cells treated for 48 h, and incubation with liver microsomes confirmed the limited metabolism of dimethoxycurcumin. Both compounds were rapidly degraded in vivo but dimethoxycurcumin was more stable. Conclusions: Compared with curcumin, dimethoxycurcumin is (a) more stable in cultured cells, (b) more potent in the ability to kill cancer cells by apoptosis, (c) less extensively metabolized in microsomal systems, and (d) more stable in vivo. It is likely that the differential extent of apoptosis induced by curcumin and dimethoxycurcumin in vitro is associated with the metabolite profiling and/or the extent of stability.Curcumin (diferuloylmethane) is the active yellow pigment in turmeric, a popular plant-derived coloring spice and ingredient of many cosmetics and pharmaceuticals (see refs. 1 -5 for reviews on structural and biological aspects of curcumin). In general, curcumin has been associated with a large number of biological and cellular activities/events, including antioxidative, anti-inflammatory, anticarcinogenic, and hypocholesterolemic properties (1 -5), and a large number of studies have focused on the pathways by which curcumin acts as a chemoprotective agent (1, 2, 6, 7). Further, curcumin congeners have been reported to induce apoptosis, sensitize and overcome resistance to various agents that induce apoptosis in diverse human cancer cells (8 -16), and decrease the occurrence of cardiomyocytic apoptosis after global cardiac ischemia/reperfusion (17). In general, curcumin mediates its effects by modulating several important molecular targets, including transcription factors, enzymes, cell cycle proteins, cytokines, receptors, and cell surface adhesion molecules (reviewed in refs. 2 -4).With regard to its anticancer potential, it has been shown that curcumin congeners can inhibit proliferation and/or induce apoptosis of cancer c...

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“…(Coleoptera: Chrysomelidae) (Rajapakse & Van Emden, 1997) and one of its major constituents, geraniol, has been shown to have repellent activity against T. castaneum and Sitotroga cerealella (Lepidoptera: Gelechiidae) (Jayasinghe & Fujimoto, 1999). Chowdhury et al (2000) reported the insecticidal properties of turmeric extracts and Pranata (1984) reported the insecticidal properties of petroleum ether extract of turmeric. Vetiver grass also produces many natural compounds that are insect-repellent (Duke, 1990).…”

Section: Introductionmentioning

confidence: 99%

Repellent, larvicidal and pupicidal properties of essential oils and their formulations against the housefly, Musca domestica

Kumar

Mishra

Malik

et al. 2011

Medical and Veterinary Entomology

123

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The essential oils of six plant species [peppermint, Mentha piperita, and bergamot mint, Mentha citrata (both, Lamiales: Lamiaceae); blue gum, Eucalyptus globulus (Myrtales: Myrtaceae); lemongrass, Cymbopogon citratus, and khus grass, Vetiver zizanoides (both, Poales: Poaceae), and turmeric, Curcuma longa (Ziniberales: Zingiberaceae)] were screened for repellent, larvicidal and pupicidal activities against the housefly, Musca domestica L. (Diptera: Muscidae). Subsequently, emulsifiable concentrate (EC) formulations of the two most effective oils were prepared and tested in the laboratory as well as in the field. In repellency bioassays, M. piperita (RC(84) , 61.0 µg/cm(2) ) was found to be most effective, followed by E. globulus (RC(84) , 214.5 µg/cm(2) ) and C. citratus (RC(84) , 289.2 µg/cm(2) ). Formulated M. piperita and E. globulus showed RC(84) values of 1.6 µg/cm(2) and 4.1 µg/cm(2) , respectively. Formulated M. piperita and E. globulus achieved larval mortality (LC(50) ) in 72 h at 5.12 µg/cm(2) and 6.09 µg/cm(2) , respectively. In pupicidal bioassays, crude oils of M. piperita and E. globulus suppressed the emergence of adult flies by 100%. Field experiments with the M. piperita formulation showed reductions in fly density (number of flies/h) of 96% on treated cattle and 98% on treated plots. This study demonstrates the effectiveness of EC formulations of selected essential oils in reducing housefly populations in field conditions.

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Isolation, characterization and insect growth inhibitory activity of major turmeric constituents and their derivatives against Schistocerca gregaria (Forsk) and Dysdercus koenigii (Walk)

Cited by 15 publications

References 0 publications

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Repellent, larvicidal and pupicidal properties of essential oils and their formulations against the housefly, Musca domestica

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