Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Tavares, Wagner de Souza; Akhtar, Yasmin; Gonçalves, Gabriel Luiz Padoan; Zanúncio, José Cola; Isman, Murray B.

doi:10.1038/srep34093

Cited by 46 publications

(27 citation statements)

References 50 publications

(65 reference statements)

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“…It significantly decreases the depletion of respiratory components (cytochrome c, NADH) (Schertl & Braun, 2014). Curcumin is a yellow colored pigment found in the turmeric's rhizome part (Curcuma longa) (de Souza Tavares, Akhtar, Gonçalves, Zanuncio, & Isman, 2016). It possesses a wide variety of applications in the field of pharmacology and cellular metabolism, which has bioprotective as well as antioxidant features (Amalraj, Pius, Gopi, & Gopi, 2017).…”

Section: Introductionmentioning

confidence: 99%

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

et al. 2019

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Gentamicin (GM) is an antibiotic related to aminoglycoside group that is used in treating Gram‐negative bacterial infections. However, treatment with gentamicin is considered to be limited as it induces an oxidative stress‐mediated apoptosis in kidney which causes a nephrotoxicity. Metformin is a well‐known biguanide that is used for treating diabetes mellitus, especially type 2. Supplement with plant metabolites or natural antioxidants produce a protective activity against many types of diseases in vivo. Curcumin is a main medicinal constituent of Curcuma longa, has reported for number of biological effects, such as antioxidant, anti‐inflammatory, and antitumor. The study aims at evaluating the metformin and curcumin alone or in combination on nephrotoxicity induced by GM. The outcome of the study shows that both metformin and curcumin, when used unaided, were effectively decreasing GM‐induced nephrotoxicity. The two drugs combination was showed synergistic effect in ameliorating a GM‐induced kidney injury, as supported by expressively improved renal dysfunction. Metformin and curcumin showed strong protection against oxidative stress in GM treated animals through decreasing the activities and expression of various antioxidative enzymes. Moreover, combination of two drugs showed an anti‐inflammatory response through reducing a level of pro‐inflammatory cytokines including tumor necrosis factor‐alpha, interleukin 1‐beta, and interleukin 6 in GM intoxicated group of animals. Furthermore, GM agitated apoptosis was affectedly diminished by the combinational treatment of metformin and curcumin via down‐regulating activity of cleaved Caspase‐3 and pro‐apoptotic factor Bax, whereas increasing anti‐apoptotic factor Bcl‐2 signaling pathways. The above results suggested that combinational treatment of metformin and curcumin might be have a synergizing effect and substantial potential against nephrotoxicity induced by GM. Practical applications Curcumin and metformin combination exhibited substantial synergistic effect against GM‐induced nephrotoxicity through reducing oxidative stress, inflammation, as well as apoptosis in kidney cells. Therefore, the method of combination of curcumin and metformin might be functional to treat or inhibit GM prompted nephrotoxicity in future.

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Section: Introductionmentioning

confidence: 99%

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

et al. 2019

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“…It was proven that each of the silver nanoparticles and curcumin has an antimicrobial action when used alone (14)(15)(16)(17)(18)(19)(20)(21)(22)(23) , Therefore we combined both materials to increase the antimicrobial action of curcumin and decrease the toxicity of silver nanoparticles that was demonstrated in previous studies (35)(36)(37)(38)(39) .…”

Section: Discussionmentioning

confidence: 98%

“…Curcumin is a natural pigment extracted from the dried rhizome of turmeric Curcuma longa that was shown to have anti-inflammatory, antimicrobial and antioxidant activities by inhibiting biofilm formation (14)(15)(16)(17)(18) . The antimicrobial effects of curcumin were significantly enhanced upon nanoparticle formation (19) .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Efficacy of Nanopropolis Coated Vs Silver-Curcumin Nanoparticles Coated Gutta-Percha Points on Various Microbial Species. A Comparative In Vitro Study

Hamid¹,

Abdel‐Aziz

Naeem

2020

Egyptian Dental Journal

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Introduction: Nanopropolis, nanosilver and curcumin have a wide antimicrobial action range. They are to be tested as a gutta-percha coating. Objectives: Comparing the antimicrobial efficacy of silver-curcumin nanoparticles versus nanopropolis coated gutta-percha against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Candida albicans and assessing the continuity of both coatings. Materials and Methods: Suspensions of both materials were loaded on filter discs, placed on the surface of agar plates inoculated with tested microbes and incubated for 24 hours. Guttapercha cones were inserted in Eppendorf tubes containing the tested materials for 24 hours, placed on the surface of agar plates inoculated with the tested microbes and incubated for 24 hours. The antimicrobial activity of the discs was determined by measuring the diameter of the inhibition zone whereas it was measured by positive response and its degree around gutta-percha. Coated gutta-percha cones were scanned under scanning electron microscope to assess the continuity of the coating. Results: Mean and Standard Deviation of the inhibition zone diameter for Silver-curcumin nanoparticles around discs were 12.35±0.71mm for E.faecalis, 20.6±0.39mm for S.aureus, 14.6±0.61mm for E.coli and 18.2±0.67mm for C.albicans. For nanopropolis they were 8.95±0.69mm for E.faecalis, 15.4±0.7mm for S.aureus, 9.75±0.86mm for E.coli and 14.8±0.63mm for Candida. The inhibition zones around gutta-percha were more pronounced for Silver-curcumin nanoparticles. Statistically significant difference was found between the inhibitory effect of silvercurcumin nanoparticles and nanopropolis against all tested microorganisms P<0.001. Nanopropolis coating was more uniform and closely adherent to the gutta-percha. Conclusion: Silver-curcumin nanoparticles have a greater antimicrobial effect compared to nanopropolis.

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“…Several herbal drugs have been reported to have anti-inflammatory action, such as turmeric, 30 ginger,31 and resveratrol 32. In this work, we focused on the anti-inflammatory of ICA in APP/PS1 mice.…”

Section: Discussionmentioning

confidence: 99%

<p>Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice</p>

Zhu¹,

Zhang²,

Li³

et al. 2019

CIA

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Background: Alzheimer’s disease (AD) is the most common neurodegenerative disorder that also involves neuroinflammation in addition to many other features. Icariin (ICA) as one of the active ingredients of Chinese herbal medicine has the immunomodulating function. This study aimed to investigate the immunotherapeutic potential of ICA on AD. Methods: APP/PS1 mice and wild type C57BL/6 mice were subjected to orally ICA administration (60 mg/kg/d) for 8 months. Then, the ethological and biochemical experiments, such as Morris water maze assay, Aβ ELISA, blood T cell flow cytometry, and plasma and brain cytokines array, were conducted to evaluate the effects of ICA administration. Results: ICA significantly improved spatial learning and memory retention in APP/PS1 mice. Long-term application of ICA could also reduce hippocampus Aβ deposition, modulate the differentiation of CD4+ T cells, and modulate the release of inflammatory cytokines in plasma and brain tissue. Conclusion: ICA shows the neuroprotective effects via modulating the CD4 + T lymphocyte-related immuno-inflammatory responses in APP/PS1 mice and may be a promising drug against AD progression.

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Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists

Cited by 46 publications

References 50 publications

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

Antimicrobial Efficacy of Nanopropolis Coated Vs Silver-Curcumin Nanoparticles Coated Gutta-Percha Points on Various Microbial Species. A Comparative In Vitro Study

<p>Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice</p>

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