Isolation, Characterization and Antioxidant Activity of Plumbago indica L. Extract

Khosla, Gayatri .; Sharma, Vikram .; Shukla, Vikesh K.

doi:10.25258/ijddt.12.3.02

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Leishman-stained blood smears were used to produce differential counts of WBC. [27][28][29] Biochemical Parameters Blood was allowed to clot & serum was collected (2500 rpm; 15 minutes) for serum glutamate pyruvic transaminase (SGPT), alkaline phosphatase (ALP), total proteins, serum glutamic oxaloacetate transaminase (SWAS), and bilirubin content by standard protocols analysis.…”

Section: Hematological Parametersmentioning

confidence: 99%

In-vitro and In-vivo Anticancer Activity of Indigofera cordifolia against Ehrlich Ascites Carcinoma

Sana,

Namratha

2024

IJPQA

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The research study investigated the anticancer properties of Indigofera cordifolia in relation to ehrlich ascites carcinoma (EAC) in mice. The substance was administered intraperitoneally at 10 mg per kilogram of body‑weight. The extract was supplied nine successive days and mice were euthanized after 24 hours since the previous dosage and after fasting for 18 hours. The antitumor impact was evaluated by measuring tumor dimensions, counting viable & non-viable cancer cells, measuring the weight of tumor, & analyzing hematological considerations of the host harboring EAC. A histopathological examination of the liver sections was conducted. The study found a statistically considerable (p &LT; 0.001) improvement in endurance times for tumor-bearing mice treated with ethanolic extraction of I. cordifolia. The extract also reduced the weight of subjects with EAC tumors. Hematological analyses indicate a reduction in hemoglobin (Hb) levels in mice treated with EAC, while extract-treated animals showed a restoration of Hb levels close to normal. Noted with a statistically significant decrease (p &LT;0.001) in red blood cell count up & boost in white blood cell count in mice supplied with the extract/fraction compared to those treated with EAC. The study stated that extract had noteworthy anticancer activity, which was equivalent to that of doxorubicin. The histological sections of the liver tissue showed enhanced hepatic architecture following treatment with a 400 mg/kg dosage of the test extract.

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Section: Hematological Parametersmentioning

confidence: 99%

In-vitro and In-vivo Anticancer Activity of Indigofera cordifolia against Ehrlich Ascites Carcinoma

Sana,

Namratha

2024

IJPQA

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“…Currently, tacrine hydrochloride (HCL) (Cognex), rivastigmine (Exelon), donepezil HCL (Aricept), galantamine (Razadyne), and several other medications are being utilised. 12 They enhance the efficiency of nerve cells that are adversely influenced by Alzheimer's disease. Despite this, the results are temporary and do not address the underlying issue.…”

Section: Introductionmentioning

confidence: 99%

Nootropic Effect of Premna mucronata Roxb Leaves on Scopolamine Challenged Alzheimer’s Disease in Rats

Sadia,

Sumalatha

2024

IJPQA

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The leaves of Premna mucronata Roxb were selected for this study due to their ability to enhance cognitive function and memory in Swiss albino rats. Each mouse group was provided with scopolamine (0.4 mg/kg) intraperitoneally per kg body‑weight, as well as two split doses of methanol extraction of P. mucronata Roxb-MEPM with 200 & 400 mg/kg (oral), for a duration of 7 days. In order to assess memory and learning, researchers employed sophisticated behavioral models such as the Morris water maze and raised plus maze. However, scopolamine is a naturally occurring substance that induces a cognitive state used as an interoceptive model. One-way ANOVA & Dunnett’s multiple comparison tests were employed with p &LT; 0.05. The outcomes of this study showed that MEPM (p &LT; 0.05) enhanced short-term & abstraction remembrance at dosages of 200 & 400 mg/kg. Additionally, there was a remarkable reduction in transfer latency on the sixth and seventh days, indicating improved learning and memory by navigating through the complex maze and reducing the time it takes to escape from the Morris water maze. Results indicate that P. mucronata Roxb showed considerable memory-enhancing efficacy in all the screening models tested.

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Isolation, Characterization and Antioxidant Activity of Plumbago indica L. Extract

Cited by 2 publications

References 9 publications

In-vitro and In-vivo Anticancer Activity of Indigofera cordifolia against Ehrlich Ascites Carcinoma

In-vitro and In-vivo Anticancer Activity of Indigofera cordifolia against Ehrlich Ascites Carcinoma

Nootropic Effect of Premna mucronata Roxb Leaves on Scopolamine Challenged Alzheimer’s Disease in Rats

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