Nootropic Effect of Premna mucronata Roxb Leaves on Scopolamine Challenged Alzheimer’s Disease in Rats

Abstract

The leaves of Premna mucronata Roxb were selected for this study due to their ability to enhance cognitive function and memory in Swiss albino rats. Each mouse group was provided with scopolamine (0.4 mg/kg) intraperitoneally per kg body‑weight, as well as two split doses of methanol extraction of P. mucronata Roxb-MEPM with 200 & 400 mg/kg (oral), for a duration of 7 days. In order to assess memory and learning, researchers employed sophisticated behavioral models such as the Morris water maze and raised plus maze. However, scopolamine is a naturally occurring substance that induces a cognitive state used as an interoceptive model. One-way ANOVA & Dunnett’s multiple comparison tests were employed with p < 0.05. The outcomes of this study showed that MEPM (p < 0.05) enhanced short-term & abstraction remembrance at dosages of 200 & 400 mg/kg. Additionally, there was a remarkable reduction in transfer latency on the sixth and seventh days, indicating improved learning and memory by navigating through the complex maze and reducing the time it takes to escape from the Morris water maze. Results indicate that P. mucronata Roxb showed considerable memory-enhancing efficacy in all the screening models tested.