Isolation and Neuroprotective Activity of Phenolic Derivatives from the Marine-Derived Fungus Penicillium janthinellum

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

“…8 The Penicillium strains have yielded many new a-pyrone lactones 423-429. 63,123,173,[207][208][209][210] The Pestalotiopsis strains were the source of d-lactones, including pestalotiopyrones A-L (430-441), 71,211 pestalotiopyrones A-C (442-444), 182 and a hydroxypestalotin diastereomer 445. 211 Allantopyrone E (446), a new apyrone with a rare substitution pattern, was isolated from an Aspergillus strain.…”

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

“…They are often found in terrestrial plants as well as in red, brown and green macroalgae (seaweeds) [26], sponges [28,29], corals [30][31][32][33] and microalgae [34]. The recent studies have shown that marine-derived microorganisms also produce these phytochemicals [35], what could be confirmed by a metagenomic analyses [36]. In addition to their primary role in plant physiology for structural scaffolding and maintenance of the plant integrity as well as in the development of the plant through lignin and pigment biosynthesis, the phenolic compounds have an important role as secondary metabolites in protection against stress, defence against predators, repellent or extermination of microorganisms or other pathogens, the fouling process and UV radiation [26].…”

“…Due to the simplicity of a benzopyrone skeleton accompanied with the possibility to easily obtain structural diversity by varying the degree of oxygenation, coumarins have attracted much attention from the medicinal chemists in order to develop new structural analogues for therapeutic utilization [160,161]. Tan et al [162] isolated alternariol (35) and its derivatives from the mangrove endophytic fungus 2240 and evaluated their antiproliferative potential by means of an MTT assay against two epidermoid carcinoma cell lines, KB and KBv200, of which the latter is a multidrug resistant cell line. Besides alternariol (35), only the alternariol methyl ether (36) exhibited significant activity with IC 50 values being 3.17, 3.12 and 4.82, 4.94 µg/mL for KB and KBv200, respectively.…”

“…Tan et al [162] isolated alternariol (35) and its derivatives from the mangrove endophytic fungus 2240 and evaluated their antiproliferative potential by means of an MTT assay against two epidermoid carcinoma cell lines, KB and KBv200, of which the latter is a multidrug resistant cell line. Besides alternariol (35), only the alternariol methyl ether (36) exhibited significant activity with IC 50 values being 3.17, 3.12 and 4.82, 4.94 µg/mL for KB and KBv200, respectively. Interestingly, the authors observed a positive correlation between a number of hydroxyl groups and a strength of antitumor effect [162].…”

“…Both 35 and 36 were also isolated from the fungus, Alternaria alterata, residing in the soft coral, Litophyton arboreum. Alternariol (35) displayed anticancer properties against leukemia cell lines (L1210 and CCRF-CEM), while derivative 36 was active against colon and lung cancer cells respectively). However, both benzocoumarins 35 and 36 were toxic to the normal human cells, the granulocyte-macrophage progenitor (CFU-GM) [163].…”