Isolation and identification of two 2,3-unsubstituted chromones from glasswort (Salicornia europaea L.).

CHIJI, Hideyuki; AIBA, Takashi; Izawa, Masao

doi:10.1271/bbb1961.42.159

Cited by 18 publications

(11 citation statements)

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“…Phenylpropanoid substitutions are commonly found in the genus . Methylene‐dioxy arrangement proposed in ( 42 ) is frequently reported in Chenopodiaceae , being also found in S. europaea . LC‐ESI/TOF MS data endorsed the proposed structures (Table ).…”

Section: Resultssupporting

confidence: 60%

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Preparative mass‐spectrometry profiling of minor concentrated metabolites in Salicornia gaudichaudiana Moq by high‐speed countercurrent chromatography and off‐line electrospray mass‐spectrometry injection

Costa

Borges

Leitão

et al. 2019

J of Separation Science

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Salicornia species have just been introduced to the European market as a vegetable named ‘samphire’, ‘green asparagus’, or ‘sea asparagus’. Due to its increasing attention, and associated value, minor compounds of Salicornia gaudichaudiana Moq were investigated. The use of countercurrent chromatography and mass spectrometry enabled the search for known, as well as potentially novel natural products. Their identification was achieved based on molecular weights and mass‐spectrometric fragmentation data. Low detection limits enabled the visualization of all compounds with their identification in almost real time close to the preparative countercurrent chromatography experiment. A list of known natural products from Salicornia genus guided the identification process of compounds occurring in Salicornia gaudichaudiana Moq by tandem mass spectrometry fragment comparison. The natural product classes were divided into four groups: chlorogenic acid derivatives; flavonoid derivatives; pentacyclic triterpenoid saponins; and other compounds.

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Section: Resultssupporting

confidence: 60%

“…Chromone, previously isolared in S. europaea , was detected at m/z 161 ( 86 ), being characterized as hydroxy chromone with molecular formula C 6 H 5 O 3 (error 0.4 ppm). A minorly concentrated derivative was suggested as methoxy ‐ hexanoate chromone at m/z 289 ( 99 ).…”

Section: Resultsmentioning

confidence: 99%

Preparative mass‐spectrometry profiling of minor concentrated metabolites in Salicornia gaudichaudiana Moq by high‐speed countercurrent chromatography and off‐line electrospray mass‐spectrometry injection

Costa

Borges

Leitão

et al. 2019

J of Separation Science

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“…Because they are rich sources of protein, vitamins, dietary fiber, essential fatty acids and minerals, they have become essential for human nutrition [4][5][6][7]. Glassworts have been reported to be rich sources of antioxidant compounds [8][9][10][11]. Therefore, the significance of glassworts is not only due to their nutritive values but also because they are an excellent source of bioactive compounds that possess potentially important therapeutic effects, such as anticancer, antioxidant, antihyperlipidemic, antidiabetic and antiinflammatory activities [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells

Altay

Kartal

Sadı

et al. 2017

ARCH BIOL SCI BELGRA

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Phase I-II detoxification and antioxidant enzymes are responsible for the detoxification and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in the metabolic activation of xenobiotics. The herb Salicornia freitagii (SF) (Amaranthaceae) is known for its anticancer, antioxidant, antidiabetic and antiinflammatory activities. In this study, we determined the bioactive phenolics in the SF methanol extract and investigated its antiproliferative potential in HT-29 human colon cancer cells. We also investigated the modulation of some phase I and II enzyme (CYP 1A1, 1A2, 2E1, GSTP1 and GPx) mRNA expression and enzymatic activities by the SF extract and its major bioactive phenolic compounds. LC/MS-MS analysis showed that the main phenolic compounds of the methanolic SF extract are vanillic acid (48 µg/100g) and p-coumaric acid (10.8 µg/100g). SF extract, vanillic acid and p-coumaric acid exhibited high antiproliferative activities in HT-29 cells, with IC 50 values of 81.79µg/mL, 98.8 µM and 221.6 µM, respectively. The mRNA expression levels of CYP1A2 and CYP2E1 were decreased, while those of GSTP1 and GPx in HT-29 cells were increased after application of either the SF extract or vanillic acid. The SF extract by itself also increased the activities of GPx and GSTP1 enzymes 1.68-and 1.49-fold, respectively. Our data indicate that the SF extract and its major bioactive compound, vanillic acid, could exert a modulatory effect on the expression of enzymes that are involved in xenobiotic activation and detoxification pathways in the gastrointestinal tract. For this reason, SF can be considered as a natural source of chemopreventive agents.

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“…Previous phytochemical studies on the genus Salicornia described the isolation of a variety of compounds: benzopyrones, lignans, flavonoids, saponins, coumarins, terpenoids, quinic acid derivatives and alkaloids [26][27][28][29][30][31][32][33][34][35][36][37][38]. To the best of our knowledge, no phytochemical work have been conducted on S. gaudichaudiana.…”

Section: Introductionmentioning

confidence: 99%

Solvent system selectivities in countercurrent chromatography using Salicornia gaudichaudiana metabolites as practical example with off-line electrospray mass-spectrometry injection profiling

Costa

Jerz

Figueiredo

et al. 2015

Journal of Chromatography A

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Isolation and identification of two 2,3-unsubstituted chromones from glasswort (Salicornia europaea L.).

Cited by 18 publications

References 0 publications

Preparative mass‐spectrometry profiling of minor concentrated metabolites in Salicornia gaudichaudiana Moq by high‐speed countercurrent chromatography and off‐line electrospray mass‐spectrometry injection

Preparative mass‐spectrometry profiling of minor concentrated metabolites in Salicornia gaudichaudiana Moq by high‐speed countercurrent chromatography and off‐line electrospray mass‐spectrometry injection

Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells

Solvent system selectivities in countercurrent chromatography using Salicornia gaudichaudiana metabolites as practical example with off-line electrospray mass-spectrometry injection profiling

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