Isolation and identification of a new neo-clerodane diterpenoid fromTeucrium chamaedrysL.

Abstract

Teucrium chamaedrys L. is an aromatic and medicinal plant used as traditional medicine. Aerial parts of the plant material were dried and extracted with hexane-dichloromethane (extract 1), ethyl acetate-dichloromethane (extract 2) and methanol-dichloromethane (extract 3) in a ratio of 1:1 at rt successively. The solvents were evaporated to give crude extracts. Extract 1 was suspended in water at 60°C then partitioned successively with hexane and ethyl acetate to give hexane and ethyl acetate portions. After the column chromatography (silica gel) of ethyl acetate extract, one new and four known compounds were isolated. The new compound was named as 1(12S,18R)-15,16-epoxy-2β,6β-dihydroxy-neo-cleroda-13(16),14-dien-20,l2-olide-l8,l9-hemiacetal (teuchamaedryn D) (4). The known compounds were teucrin A (1), dihydroteugin (2), teucroxide (3), syspirensin A (5). The chromatographic methods were also applied for extract 3 to isolate verbascoside (6) and teucrioside (7). The structure of isolated compounds was elucidated by spectroscopic methods including LC-TOF/MS, 1D NMR and 2D NMR.

Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

“…Antiproliferative effect was investigated on HeLa cell lines and was demonstrated to have excellent antiproliferative activity (Figure 1). Flavonoids are one of the most common polyphenols, and they exhibit interesting and beneficial medicinal and pharmaceutical effects [13][14][15][16]. The various biological properties of flavonoids, such as antioxidant, antiinflammatory, anticancer, antibacterial, immunestimulating and antiviral activities, have been reported extensively [17].…”

Altered apoptosis and biotransformation signaling in HCT-116 colorectal carcinoma cells induced by Teucrium chamaedrys L. extract

“…Various phytochemicals, present or isolated from T. chamaedrys, may be responsible for the pro-apoptotic activity. The known compounds observed in the T. chamaedrys were mainly phenolics, essential oil, diterpenoids teucrins A, E, F and G, dihydroteugin, teucroxide, syspirensin, teuchamaedryn D and many other (LIN et al, 2009;ELMASTASA et al, 2015). The terpenes isolated from the T. alopecurus triggered apoptosis in HCT-116, U266, SCC4, Panc28, KBM5 and MCF-7 human cell lines (GUESMI et al, 2018).…”

Galanthus krasnovii (Amaryllidaceae)'nin toplam fenolik içeriği ile antioksidan kapasitenin değerlendirilmesi

“…Plants play a significant role in drug discovery process. Since they reveal plenty of pharmaceutical properties, isolation of bioactive compounds from plants gains the great interest to find the most effective compounds with activity mechanism Demirtas et al, 2013;Elmastas et al, 2016;Elmastaş et al, 2015;Erenler, Meral, et al, 2017;Erenler et al, 2018;Guzel et al, 2017;Karan et al, 2017;Karan & Erenler 2017a;Karan & Erenler 2017b;Topçu et al, 1999;Yaglıoglu et al, 2013;Yildiz et al, 2017).…”