Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

Abstract

Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.

Quantitative analysis of phenolic compounds of commercial basil cultivars (Ocimum basilicum L.) by LC-TOF-MS and their antioxidant effects

“…[5][6][7][8][9] The importance of natural products is due to the active compounds they contain. [10][11][12][13][14][15][16][17][18] Ocimum basilicum L., basil, which is an aromatic and medicinal plant belonging to the Labiatae family consists of more than 150 species. Although this plant is native to Mediterranean, Africa, America and Asia, it is widely grown in many countries.…”

Galanthus woronowii (Amaryllidaceae)'nin antioksidan aktivitesi ve toplam fenolik içeriği.

“…They included secondary metabolites revealing a great many biological activities (Elmastas et al, 2016;Erenler, Pabuccu, et al, 2016;Erenler, Sen, Yildiz, et al, 2016). A large number of medicines include natural products as main active ingredients (Erenler, Demirtas, et al, 2017;Erenler et al, 2018;. Due to the including of bioactive compounds, isolation and identification of corresponding compounds have gained the great interest lately.…”