Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis

Kaihui, Liu; Ding, Xiaowei; Deng, Bingyao; Chen, Wenqiang

doi:10.1007/s10295-009-0598-8

Cited by 151 publications

(77 citation statements)

References 24 publications

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“…Chaetomella raphigera Terminalia arjuna [227] Cladosporium cladosporioides T. media [228] Cladosporium oxysporum Moringa oleifera [229] Cladosporium tenuissimum T. chinensis [223] Colletotrichum gloeosporioides Colletotrichum sp.…”

Section: T Chinensis [223]unclassified

“…T. chinensis [223] Phoma betae G. biloba [265] Phyllosticta melochiae Melochia corchorifolia [267] Phyllosticta sp. Ocimum basilicum [268] Phyllosticta spinarum Cupressus sp.…”

Section: W Nobilis Catharanthus Roseusmentioning

confidence: 99%

“…T. media [270] Seimatoantlerium nepalense T. wallichiana [271] Sordaria sp. T. chinensis [223] Sporormia minima T. wallichiana [272] Stegolerium kukenani Stegolepis guianensis [273] Stemphylium sedicola T. baccata [274] Taxomyces andreanae T. brevifolia [214] Taxomyces sp. Taxus sp.…”

Section: W Nobilis Catharanthus Roseusmentioning

confidence: 99%

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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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Section: T Chinensis [223]unclassified

“…T. chinensis [223] Phoma betae G. biloba [265] Phyllosticta melochiae Melochia corchorifolia [267] Phyllosticta sp. Ocimum basilicum [268] Phyllosticta spinarum Cupressus sp.…”

Section: W Nobilis Catharanthus Roseusmentioning

confidence: 99%

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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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“…68 Metarhizium anisopiliae H-27, isolated from the tree Taxus chinensis, yielded 846 μg l − 1 . 69 Although a review of taxol production by endophytic fungi indicated that strain improvement had resulted in levels of only 0.4-1.0 mg l − 1 , 70 it was reported that another fungus, Alternaria alternate var. monosporus, from the bark of Taxus yunanensis, after ultraviolet and nitrosoguanidine mutagenesis, could produce taxol at 227 mg l − 1 .…”

Section: Antineoplastic Drugsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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“…Endophytic fungi could produce antibiotic, antiviral, anticancer, and insecticide compounds [8,9]. The endophytic fungi species in Ginkgo biloba could produce active compounds that have characters antimicrobe, antioxidant, cytotoxic, etc [10][11][12][13][14]. The medicinal plants used frequently belongs to Zingiberaceae.…”

Section: Introductionmentioning

confidence: 99%

Histologic observation, identification, and secondary metabolites analysis of endophytic fungi isolated from a medicinal plant, hedychium acuminatum Roscoe

Hastuti¹,

Asna²,

Rahmawati³

2018

AIP Conference Proceedings

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Abstract. Some endophytic fungi live in medicinal plant tissue and could produce some secondary metabolites. This research was done to 1) determine the endophytic fungi position in the Hedychium acuminatum Roscoe. plant tissue by histological observation, 2) identify the endophytic fungi species isolated from the rhizome, leaf sheath, and the leaf of H. acuminatum, and 3) analyze the contents of some secondary metabolites that be produced by the endophytic fungi species isolated from H. acuminatum. The determination of the position of endophytic fungi in the H. acuminatum plant tissue was done by histologic observation. The endophytic fungi were isolated from H. acuminatum plant, then were inoculated on Potato Dextrose Agar medium and incubated at 25 °C during 7 to 14 × 24 h. Each endophytic fungus isolate was identified. Each endophytic fungus isolate was inoculated in Potato Dextrose Broth medium and shook at 120 rpm for 7 × 24 h; then the secondary metabolites content was analyzed using the spectrophotometric method. The research result was: 1) the endophytic fungi mycelium were found on the parenchyma cell wall and intercellular space of rhizome, epidermis and parenchyma cell wall of leaf sheath, epidermis cell wall of leaf; 2) eleven endophytic fungi species were found: Rhizoctonia sp., Fusarium solani, F. oxysporum, Colletotrichum alienum, C. aotearoa, C. ti, Aspergillus parasiticus, C. coccodes, C. gloeosporoides, Hansfordia biophila, and F. semitectum; 3) the secondary metabolites content in fungi culture in broth medium are: alkaloid 20.48 μm · mL -1 to 117.12 μm · mL -1 ), flavonoid (148.48 μm · mL -1 to 816.96 μm · mL -1 ), terpenoid (4.73 μm · mL -1 to 32.98 μm · mL -1 ), and tannin (9.39 μm · mL -1 to 53.02 μm · mL -1 ).

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Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis

Cited by 151 publications

References 24 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Production of valuable compounds by molds and yeasts

Histologic observation, identification, and secondary metabolites analysis of endophytic fungi isolated from a medicinal plant, hedychium acuminatum Roscoe

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