Production of valuable compounds by molds and yeasts

Abstract

where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

Application of Aluminum Oxide Nanoparticles inAspergillus terreusCultivations: Evaluating the Effects on Lovastatin Production and Fungal Morphology

“…The remarkable biosynthetic capabilities of filamentous fungi are of central importance to microbiology and biotechnology, especially in the context of industrial manufacturing of chemicals, e.g., organic acids, enzymes, and secondary metabolites [1, 2]. Even though the molecules of microbial origin have been studied for decades both in industry and academia, it is believed that the rich biosynthetic catalogue of fungi remains mostly unexplored and harbors a myriad of potentially useful compounds.…”

Morphological evolution of various fungal species in the presence and absence of aluminum oxide microparticles: Comparative and quantitative insights into microparticle‐enhanced cultivation (MPEC)

“…Filamentous fungi are of central relevance to biotechnological industry due to their prolific biosynthetic capabilities. Widely exploited for the production of valuable metabolites and enzymes, these organisms constitute the core of important large‐scale biomanufacturing processes (Adrio & Demain, ; Demain & Martens, ). The development of cost‐effective cultivation strategies is thus an essential prerequisite for harnessing the enormous biochemical potential of fungal strains.…”

Extraction and optimisation of red pigment production as secondary metabolites from Talaromyces verruculosus and its potential use in textile industries

“…In addition, many of these compounds have been found to have important applications, for instance, as antibiotics or immunosuppressant (Brakhage 2013), food colourant, etc. The secondary metabolites from fungi found their applications as anti-rejection drugs, enzyme activity blocking agent, cholesterol lowering agent, prebiotics, food additives replacing sugar, toxins, antineoplastic drugs, anti-cancer drug (Somjaipeng et al 2015), antimicrobials, production of organic acids (Roberts et al 2016), proteins, vitamins, biofuels, dye effluent treatment (Porri et al 2011) and in pigment production (Arai et al 2015;Demain & Martens 2016). Carotenoids obtained from several unique fungi species have obtained special attention as colourants considering their advancements towards commercialisation (Schweiggert & Carle 2016).…”