Isolation and Characterization of Collagen in Peyronie’s Disease

Somers, Kenneth D.; Sismour, Edward; Wright, George L.; Devine, Charles J.; Gilbert, David A.; Horton, Charles E.

doi:10.1016/s0022-5347(17)40920-7

Cited by 87 publications

(54 citation statements)

References 12 publications

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“…11 Although type I and III collagen is present in penile scar tissue, type III collagen is more abundant in tunica of men with Peyronie's plaques. 4 The middle-aged and older men are more prone to such injury and plaque formation because of reduced penile elasticity, while this finding is rare in the tunica albuginea of young potent men. 9 Cellular and physiological aging has been associated with increased oxidative stress and ROS production.…”

Section: Oxidative Stress and Pathophysiology Of Peyronie's Diseasementioning

confidence: 99%

“…Recent scientific developments in understanding the pathophysiology of this localized connective tissue disorder, which is characterized by the presence of one or more fibrous plaques has shown an excessive amount of collagen and elastin in the tunica albuginea of the penis. 3,4 Both collagen and elastin play a vital role in the penile elasticity, rigidity, vascular compliance, and veno-occlusion mechanisms. Several etiological factors have been proposed to explain fibrosis and plaque formation in Peyronie's disease.…”

Section: Introductionmentioning

confidence: 99%

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Role of oxidative stress and antioxidants in Peyronie's disease

2002

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Section: Oxidative Stress and Pathophysiology Of Peyronie's Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of oxidative stress and antioxidants in Peyronie's disease

2002

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“…22,24 Peyronie's plaques are also composed almost entirely of types I and III collagen. 24,25 While collagen has a greater tensile strength than steel, it is unyielding. In contrast, elastin can be stretched up to 150%, of its length.…”

Section: The Microscopic Anatomy Of the Tunica Albuginea And Its Impamentioning

confidence: 99%

Pathophysiology of Peyronie's disease

Moreland

Nehra

2002

Int J Impot Res

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“…Microscopically, the tunica albuginea is largely composed by fibrillar collagen type I, woven with elastin fibers, in order to form organized structures (5). Even the plaques of PD are mostly constituted from collagen type I and III (6), but the elastin component, which gives to the tunica albuginea elongation properties up to 150%, is altered: the decrease elastin, as well the alterations in the arrangement of the tunic layers, are characteristics of PD, that can lead to deviations in penile erection and erectile dysfunction (7). More recent papers have identified a strong association of PD with both Dupuytren's disease and the HLA B-27 (8).…”

Section: Discussionmentioning

confidence: 99%

Animal experimental model of Peyronie’s disease: A pilot study

Cerruto¹,

D’Elia

Molinari³

et al. 2013

Arch Ital Urol Androl

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The Peyronie's disease (PD) is an idiopathic disorder of connective tissue of the penis, that involves the tunica albuginea of the corpora cavernosa and the adjacent areolar space. A fibrous plaque replaces the elastic fibers that normally constitute the tunica albuginea, limiting its extensibility, and causing pain during erection, erectile dysfunction and difficulty of penetration, as a result of the deviation of the penis. Although it was once considered a relatively infrequent disease, some studies show that the prevalence of IPP is Results: The MRI acquisitions, both in coronal and axial projection, showed an adequate visibility of the anatomical structures. At 7 days after thrombin injection with the dartos incision it was evident an oedematous portion, visible as a hyperintense area, located at the injection area. At 21 days after injection, oedema was partially resolved: the injection part of the hyperintense area remains unchanged, while the remaining area appears to be part of a re-absorption and re-organization process. Conclusions: Since none of the various treatment modalities currently available for the management of PD is able to bring healing, the researchers' attention is increasingly directed towards innovative treatment programs, such as the use of stem cells of mesenchymal origin. At the present time, the research in PD is hampered by the lack of universally accepted animal model and this is likely attributed to the limited insight into PD mechanisms and the difficulties faced by current animal models to truly represent the complexity.

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Isolation and Characterization of Collagen in Peyronie’s Disease

Cited by 87 publications

References 12 publications

Role of oxidative stress and antioxidants in Peyronie's disease

Role of oxidative stress and antioxidants in Peyronie's disease

Pathophysiology of Peyronie's disease

Animal experimental model of Peyronie’s disease: A pilot study

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