Role of oxidative stress and antioxidants in Peyronie's disease

Sikka, Suresh C.; Hellstrom, Wayne J.G.

doi:10.1038/sj.ijir.3900880

Cited by 143 publications

(169 citation statements)

References 47 publications

(45 reference statements)

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“…In the context of human reproduction, excessive ROS production that exceeds critical levels can overwhelm antioxidant defense strategies of spermatozoa and seminal plasma, causing OS (2,62,63). All cellular components including lipids, proteins, nucleic acids, and sugars are potential targets for OS.…”

Section: Pathological Effects Of Increased Ros: the Concept Of Osmentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,272

909

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Objective: To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction. Design: Review of literature. Setting: Fertility research center and obstetrics and gynecology department in a tertiary care facility. Result(s): ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor infertility, oxidative stress attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. Reactive oxygen species induced DNA damage may accelerate the process of germ cell apoptosis, leading to the decline in sperm counts associated with male infertility. ROS mediated female fertility disorders share many pathogenic similarities with the ones on the male side. These similarities include a potential role in the pathophysiology of endometriosis and unexplained infertility. High follicular fluid ROS levels are associated with negative IVF outcomes, particularly in smokers. Moreover, oxidative stress may be responsible in hydrosalpingeal fluid mediated embryotoxicity as well as poor in vitro embryonic development. Conclusion(s):High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states. (Fertil Steril 2003;79:829 -43.

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Section: Pathological Effects Of Increased Ros: the Concept Of Osmentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,272

909

View full text Add to dashboard Cite

show abstract

“…However, increased CAT, SOD and MDA levels in fine-needle aspiration, macro-TESE and Tru-cut biopsy groups were found higher than in the sham group. Techniques in these groups [2,4,5] may cause oxidative stress. Besides, increased antioxidant enzyme activities (CAT, SOD) may demonstrate the cellular response against oxidative stress in these groups.…”

Section: Discussionmentioning

confidence: 99%

“…There is a balance between the different antioxidants and oxidants at normal status [4]. Oxidative stress develops when oxidants outnumber antioxidants, and peroxidation products occur, and these may cause pathologic effects [5,6]. ROS are believed to have potential toxic effects at high levels on sperm quality and function in the male reproductive tract [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The Levels of Oxidative Stress Biomarkers in Rats as a Response to Different Techniques of Testicular Biopsy

et al. 2013

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“…32 Vitamin E, a fat-soluble vitamin metabolized in the liver, excreted in bile is an antioxidant that is thought to limit oxidative stress of reactive oxygen species known to be increased during the acute and proliferative phases of wound healing. 33 Increased free radical expression and a prolonged inflammatory phase of wound healing has been demonstrated in PD. 4,33 In 1983, Pryor and Farell 34 conducted a double-blind, placebo-controlled crossover study evaluating vitamin E for the treatment of PD in 40 patients.…”

Section: Carnitinementioning

confidence: 99%

“…33 Increased free radical expression and a prolonged inflammatory phase of wound healing has been demonstrated in PD. 4,33 In 1983, Pryor and Farell 34 conducted a double-blind, placebo-controlled crossover study evaluating vitamin E for the treatment of PD in 40 patients. No significant improvements were noted in plaque size or penile curvature.…”

Section: Carnitinementioning

confidence: 99%