Isolation and Characterization of a Hypoglycemic Agent from Xanthium strumarium

Kupiecki, Floyd P.; Ogzewalla, C. Dwayne; Schell, Fred M.

doi:10.1002/jps.2600630736

Cited by 24 publications

(9 citation statements)

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“…In fact, many plants containing sulfur are used traditionally as antidiabetics. [16–17] These compounds produce an increase in insulin, probably by inhibition of some substances competing with insulin for their SH-group. The results were comparable with that of tolbutamide, which acts by stimulation of insulin release,[18] thus further confirming that the extract lowers the blood glucose by a pancreatotrophic action.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats

et al. 2008

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Objective:To find out the hypoglycemic and hypolipidemic activity of an ethanolic extract of the aerial part of Salvadora oleoides Decne in euglycemic and alloxan-induced diabetic albino rats.Materials and Methods:Diabetes was induced in albino rats by administration of alloxan monohydrate (120 mg/kg, i.p.). Normal as well as diabetic albino rats were divided into groups (n = 6) receiving different treatments: vehicle (control), ethanolic extract (1 g and 2 g/kg b.w), and standard antidiabetic drug tolbutamide (0.5 g/kg b.w.). Blood samples were collected by cardiac puncture and were analyzed for blood glucose and lipid profile on days 0, 7, 14, and 21.Results:The ethanolic extract of S oleoides produced significant reduction (P < 0.001) in blood glucose and also had beneficial effects (P < 0.001) on the lipid profile in euglycemic as well as alloxan-induced diabetic rats at the end of the treatment period (21st day). However, the reduction in the blood glucose and improvement in lipid profile was less than that achieved with the standard drug tolbutamide.Conclusion:We concluded that an ethanolic extract of S oleoides is effective in controlling blood glucose levels and improves lipid profile in euglycemic as well as diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats

et al. 2008

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“…Many plants containing organo-sulphur compounds are used traditionally as potent hypoglycemic for symptoms related to the condition. (12) Trovato et al observed hypoglycemic effect, an increase in plasma immunoreactive insulin (IRI) and an incremented oral-glucose tolerance in normal rats with significant decrease in mean body weights, when treated with a stem decoction of Salvadora persica. (13) According to Trovato et al the ability of stem decoction to improve the utilization of glucose following a glucose load, may indicate the possible mechanism of hypoglycemic activity of this plant decoction, which further may facilitate peripheral utilization of the glucose, either by direct stimulation of glucose uptake or by enhanced insulin secretion.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Activities of Arabic and Indian Origin Salvadora Persica Root Extract on Diabetic Rats with Histopathology of Their Pancreas

Khan

Ali

et al. 2014

IJHS

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Objective: To evaluate hypoglycemic and hypolipidemic effects of Salvadora persica aqueous extracts on streptozotocininduced diabetic rats by measuring fasting blood glucose levels, lipid profiles and histopathological analysis of pancreas. Materials and Methods:Experimental Diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg/kg) to albino Wistar rats. Salvadora persica extracts were administered orally at 250 and 500 mg/kg dose levels for 21 days. Glucose tolerance test (GTT) was performed on 16 h fasted rats and changes in blood glucose levels, total cholesterol, triglycerides, lowdensity lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and histopathology of pancreas were performed. Results:At a dose level of 500 mg/kg, blood glucose 85.25 ± 13.20 mg/dl, total cholesterol (TC) 114.57 ± 15.81(mg/dl), triglycerides (TG) 75.40 ± 16.47(mg/dl), LDL 42.63 ± 13.17(mg/dl), VLDL 22.78 ± 1.88(mg/dl), and elevation of HDL 44.88 ± 11.61(mg/dl) were found in comparison with diabetic control on 28 th day by Arabic origin Salvadora persica. It also accelerated the regeneration of β-cells in experimental animal's pancreas to 32.6 ± 2.4 compared to diabetic control animal's pancreas of 8.1 ± 0.5 at the end of 28 th day. Conclusion:This study confirmed that Arabic Salvadora persica aqueous extracts at 500 mg/kg dose level, in comparison to other extracts (Indian Salvadora persica, 250 and 500 mg/kg, Arabic Salvadora persica 250 mg/kg) possessed significant hypoglycemic and hypolipidemic activities and regenerated pancreatic β-cells in streptozotocin treated diabetic rats.

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“…Thus, the stem extract proved to be more potent than the leaf extract, and may contain greater concentrations of similar analgesic component(s), or more potent but different analgesic component(s) than the leaf extract. It is to be noted that a hypoglycemic agent, carboxyatractyloside, has been isolated from a related species, X. strumarium [ 15 ]. X. strumarium extract also reportedly demonstrated antinociceptive property, which was attributed to presence of caffeoylquinic acids in the extract [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of antihyperglycemic and antinociceptive activity of Xanthium indicum stem extract in Swiss albino mice

Haque

Rahman

Rahmatullah

et al. 2013

BMC Complement Altern Med

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BackgroundXanthium indicum stem is used in folk medicine of Bangladesh to control sugar in diabetic patients and to alleviate pain. The objective of the study was to evaluate antihyperglycemic and antinociceptive activity of methanolic extract of Xanthium indicum stems (XISE) in mice.MethodsAntihyperglycemic activity was measured by oral glucose tolerance tests in glucose-loaded Swiss albino mice. Antinociceptive activity was determined by observed decreases in abdominal constrictions in acetic acid-induced gastric pain model in mice.ResultsThe methanol extract of stems showed dose-dependent and statistically significant antihyperglycemic activity at doses of 50, 100, 200 and 400 mg per kg body weight (p values, respectively, < than 0.01, 0.01, 0.005, and 0.01). Highest reduction in blood glucose level (31.2%) was observed with the highest dose (400 mg) of the extract. A standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 46.2%, when administered at a dose of 10 mg per kg body weight. In antinociceptive activity tests, the extract when administered at the afore-mentioned four doses, reduced the number of abdominal constrictions in mice, respectively, by 41.7, 50.0, 54.2, and 61.0%. In comparison, a standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight, reduced the number of abdominal constrictions by 37.5%.ConclusionThe experimental results obtained in the present study validate the use of X. indicum stems in folk medicines of Bangladesh to lower blood sugar in diabetic patients and to alleviate pain.

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Isolation and Characterization of a Hypoglycemic Agent from Xanthium strumarium

Cited by 24 publications

References 4 publications

Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats

Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats

Hypoglycemic and Hypolipidemic Activities of Arabic and Indian Origin Salvadora Persica Root Extract on Diabetic Rats with Histopathology of Their Pancreas

Evaluation of antihyperglycemic and antinociceptive activity of Xanthium indicum stem extract in Swiss albino mice

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