Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs

Soyata, Amelia; Hasanah, Aliya Nur; Rusdiana, Taofik

doi:10.4274/tjps.galenos.2020.79106

Cited by 8 publications

(3 citation statements)

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“…Numerous medications, including celecoxib, theophylline, paclitaxel, midazolam, imatinib, carbamazepine, valproic acid, repaglinide, omeprazole, and danofloxacin, may interact when soy isoflavone intake is excessively high over a prolonged period of time (Soyata et al, 2021). Isoflavones might also interfere with tamoxifen, used in breast cancer treatment, and the drug raloxifene, used to prevent and treat osteoporosis.…”

Section: Resultsmentioning

confidence: 99%

Effect of soy isoflavones on bone health among female university students: a pilot study

Goja,

Al-Otaishan,

Al-Awami

et al. 2023

Emir J Food Agric

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Low bone mineral density (BMD) has become more common in young women. In postmenopausal women, soy isoflavones have been demonstrated to have a powerful influence on bone health when taken as a food supplement. It is unclear how soy isoflavones affect premenopausal women, though. This study looked at how soy isoflavones affected female university students’ BMD. Thirty female students, aged 18 to 25, were introduced to a Quasi-experimental design, where only 28 could complete the study. Participants received soy isoflavone at 60 mg/day for 28 days. BMD was assessed using dual-energy x-ray absorptiometry (DEXA) before and after supplementation. In addition, twenty-four hours food recall and food frequency questioners (FFQ) were used to evaluate the dietary intake of participants. The prevalence of osteoporosis among participants was 18% osteoporosis, 61% osteopenia and 21% normal. After 4 weeks of intervention, a slight improvement in the BMD was recorded. This improvement was noticed in 33, 59, and 40% of normal,osteopenia, and osteoporosis participants, respectively. Soy isoflavone supplementation can be useful in decreasing the risk of osteopenia among premenopausal women. These promising results ensure the viability of conducting full-scale clinical trials to thoroughly look at the relationship between soy isoflavones and bone health among pre-menopausal women. Keywords: Osteoporosis; Bone mineral density; Soy isoflavone; Saudi Arabia

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Section: Resultsmentioning

confidence: 99%

Effect of soy isoflavones on bone health among female university students: a pilot study

Goja,

Al-Otaishan,

Al-Awami

et al. 2023

Emir J Food Agric

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“…Tempeh and tofu are foods in Indonesia that are rich in protein; the participants consumed this food daily because it is readily available and relatively inexpensive compared to other sources of protein. Tempe is made from soybeans, which contain high isoflavones [40], which are antioxidants that play a role in activating the nuclear E2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway to modulate the expression of cytoprotective enzymes and counteract oxidative damage [41]. A previous study reported that children consuming more dairy, milk, and yogurt had lower BLLs [36].…”

Section: Discussionmentioning

confidence: 99%

The Role of Protein Intake on the Total Milk Protein in Lead-Exposed Lactating Mothers

et al. 2023

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Protein is an essential macronutrient for the growth and development of infants. Protein levels in lactating mothers are dynamic and influenced by various factors, particularly the environment and maternal characteristics. Therefore, this study aimed to evaluate the complex correlation between maternal blood lead levels (BLLs), maternal diet, and total milk protein. The Kruskal–Wallis test was used to compare total milk protein in the three groups of lead exposure, while Spearman’s correlation was used to assess the correlation between maternal diet, BLLs, and total milk protein. The multivariate analysis used multiple linear regression. The results showed that the median of maternal BLLs and total milk protein were 3.3 µg/dL and 1.07 g/dL, respectively. Maternal protein intake and current BMI had a positive correlation with total milk protein, while BLLs had a negative correlation. BLLs ≥ 5 μg/dL had the most significant impact on reducing the total milk protein (p = 0.032). However, increasing maternal protein intake can effectively maintain total milk protein levels in mothers with BLLs under 5 μg/dL (p < 0.001). It is crucial to measure BLLs in lactating mothers residing in areas exposed to lead because high maternal protein intake can only maintain total milk protein levels when the BLLs are <5 μg/dL.

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“…These proportions vary by many factors, such as the soy variety and processing conditions. [66,67]. In tofu whey, daidzein and genistein are present in the highest concentrations [68].…”

Section: Foulingmentioning

confidence: 98%

Identification of Fouling Occurring during Coupled Electrodialysis and Bipolar Membrane Electrodialysis Treatment for Tofu Whey Protein Recovery

Deschênes Gagnon,

Langevin,

Lutin

et al. 2024

Membranes

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Tofu whey, a by-product of tofu production, is rich in nutrients such as proteins, minerals, fats, sugars and polyphenols. In a previous work, protein recovery from tofu whey was studied by using a coupled environmental process of ED + EDBM to valorize this by-product. This process allowed protein recovery by reducing the ionic strength of tofu whey during the ED process and acidifying the proteins to their isoelectric point during EDBM. However, membrane fouling was not investigated. The current study focuses on the fouling of membranes at each step of this ED and EDBM process. Despite a reduction in the membrane conductivities and some changes in the mineral composition of the membranes, no scaling was evident after three runs of the process with the same membranes. However, it appeared that the main fouling was due to the presence of isoflavones, the main polyphenols in tofu whey. Indeed, a higher concentration was observed on the AEMs, giving them a yellow coloration, while small amounts were found in the CEMs, and there were no traces on the BPMs. The glycosylated forms of isoflavones were present in higher concentrations than the aglycone forms, probably due to their high amounts of hydroxyl groups, which can interact with the membrane matrices. In addition, the higher concentration of isoflavones on the AEMs seems to be due to a combination of electrostatic interactions, hydrogen bonding, and π–π stacking, whereas only π–π stacking and hydrogen bonds were possible with the CEMs. To the best of our knowledge, this is the first study to investigate the potential fouling of BPMs by polyphenols, report the fouling of IEMs by isoflavones and propose potential interactions.

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Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs

Cited by 8 publications

References 0 publications

Effect of soy isoflavones on bone health among female university students: a pilot study

Effect of soy isoflavones on bone health among female university students: a pilot study

The Role of Protein Intake on the Total Milk Protein in Lead-Exposed Lactating Mothers

Identification of Fouling Occurring during Coupled Electrodialysis and Bipolar Membrane Electrodialysis Treatment for Tofu Whey Protein Recovery

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