Isoflavone Content and Anti-acetylcholinesterase Activity in Commercial Douchi (a Traditional Chinese Salt-fermented Soybean Food)

Liu, Yaqiong; Wang, Lijun; Cheng, Yunhui; Saito, Masayoshi; Yamaki, Kohji; Qiao, Zhihong; Li-te, LI

doi:10.6090/jarq.43.301

Cited by 9 publications

(7 citation statements)

References 33 publications

(40 reference statements)

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“…Furthermore, all fractionated hydrolysates inhibited acetylcholinesterase activity and the high MW fractions showed greater AChE inhibitory activities than LMW fractions [ 76 ]. The AChE inhibitory activity of Douchi—a traditional Chinese salt-fermented soybean food was examined and observed inhibition was attributed bioactive peptides generated from soybean protein following fermentation [ 80 ]. Similarly, the AChE inhibitory activity of Chinese sufu (fermented tofu) was observed by Chen and colleagues [ 81 ].…”

Section: Peptides In Mental Health and Prevention Of Diabetes Pep/mentioning

confidence: 99%

Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities

Hayes

Tiwari

2015

IJMS

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Bioactive peptides and carbohydrates are sourced from a myriad of plant, animal and insects and have huge potential for use as food ingredients and pharmaceuticals. However, downstream processing bottlenecks hinder the potential use of these natural bioactive compounds and add cost to production processes. This review discusses the health benefits and bioactivities associated with peptides and carbohydrates of natural origin and downstream processing methodologies and novel processes which may be used to overcome these.

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Section: Peptides In Mental Health and Prevention Of Diabetes Pep/mentioning

confidence: 99%

Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities

Hayes

Tiwari

2015

IJMS

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“…Soy isoflavones are mainly as daidzein, genistein, and its glycosides. 106 When daidzein reaches the colon, it is metabolized via dihydrodaidzein into O-desmethylangolensin (O-DMA) or equol, a substance beneficial for human health. Equol-producing bacteria belong to the following groups: Eggerthella, Asaccharobacter, Lactobacillus, Adlercreutzia, Enterohabdus, Eubacterium, Acinetobacter, Slackia, and Proteus.…”

Section: ■ Nutrition and Phytochemicals Of Cclgsmentioning

confidence: 99%

“…Another paradigmatic example is the role of GM as a key driver of the effects of isoflavones (present in soybean). Soy isoflavones are mainly as daidzein, genistein, and its glycosides . When daidzein reaches the colon, it is metabolized via dihydrodaidzein into O -desmethylangolensin ( O -DMA) or equol, a substance beneficial for human health.…”

Section: Cclg Metabolism Involves Gmmentioning

confidence: 99%

Coarse Cereals and Legume Grains Exert Beneficial Effects through Their Interaction with Gut Microbiota: A Review

Yao

Cao

Peng

et al. 2020

J. Agric. Food Chem.

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Coarse cereals and legume grains (CCLGs) are rich in specific macro- and functional elements that are considered important dietary components for maintaining human health. Therefore, determining the precise nutritional mechanism involved in exerting the health benefits of CCLGs can help understand dietary nutrition in a better manner. Evidence suggests that gut microbiota play a crucial role in the function of CCLGs via their complicated interplay with CCLGs. First, CCLGs modulate gut microbiota and function. Second, gut microbiota convert CCLGs into compounds that perform different functions. Third, gut microbiota mediate interactions among different CCLG components. Therefore, using gut microbiota to expound the nutritional mechanism of CCLGs is important for future studies. A precise and rapid gut microbiota research model is required to screen and evaluate the quality of CCLGs. The outcomes of such research may promote the rapid discovery, classification, and evaluation of CCLG resources, thereby opening a new opportunity to guide nutrition-based development of CCLG products.

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“…The IC 50 value of AChE inhibitory activities of Douchi extracts ranged from 0.040 to 2.319 mg/mL. Douchi extracts using Aspergillus exhibited significantly higher AChE inhibitory activity than using Mucor and Bacillus [ 70 ]. The other fermentation based product is sufu (fermented tofu), a traditional Chinese food, that has been manufactured by fermenting soybean (yellow soybean & black soybean).…”

Section: Neuropeptides From Plant Sourcesmentioning

confidence: 99%

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Prasasty

Radifar²,

Istyastono

2018

Molecules

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Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer’s disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

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Isoflavone Content and Anti-acetylcholinesterase Activity in Commercial Douchi (a Traditional Chinese Salt-fermented Soybean Food)

Cited by 9 publications

References 33 publications

Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities

Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities

Coarse Cereals and Legume Grains Exert Beneficial Effects through Their Interaction with Gut Microbiota: A Review

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

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