Skin exhibits nonlinear mechanics, which is initially soft and stiffens rapidly as being stretched to prevent large deformationâinduced injuries. Developing skinâinterfaced bioelectronics with skinâinspired nonlinear mechanical behavior, together with multiple other desired features (breathable, antibacterial, and sticky), is desirable yet challenging. Herein, this study reports the design, fabrication, and biomedical application of porous mesh bioelectronics that can simultaneously achieve these features. On the one hand, porous serpentine meshes of polyimide (PI) are designed and fabricated under the guidance of theoretical simulations to provide skinâlike nonlinear mechanics and high breathability. On the other hand, ultrasoft, sticky, and antibacterial polydimethylsiloxane (PDMS) is developed through epsilon polylysine (ΔâPL) modifications, which currently lacks in the field. Here, ΔâPLâmodified PDMS is sprayâcoated on PI meshes to form the coreâshell structures without blocking their pores to offer ultrasoft, sticky, and antibacterial skin interfaces. And rationally designed porous hybrid meshes can not only retain skinâlike nonlinear mechanical properties but also enable the integration of both soft and hard bioelectronic components for various healthcare applications. As the exemplar example, this study integrates soft silver nanowires (AgNWs) based electrophysiological sensors and rigid commercial accelerometers on multifunctional porous meshes for concurrently monitoring heart electrical and mechanical functions to provide the comprehensive information of the evolving heart status.